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International Journal of Endocrinology
Volume 2010 (2010), Article ID 205357, 14 pages
http://dx.doi.org/10.1155/2010/205357
Review Article

Potential Role of Sugar Transporters in Cancer and Their Relationship with Anticancer Therapy

1Biomedical Research Institute, A Coruña University Hospital, As Xubias 84, 15006 A Coruña, Spain
2Clinical Oncology Department, Ramón y Cajal University Hospital, Ctra. de Colmenar Viejo Km. 9,100, 28034 Madrid, Spain
3Clinical Oncology Department, A Coruña University Hospital, As Xubias 84, 15006 A Coruña, Spain
4Medicine Department, University of A Coruña, Oza s/n, 15006 A Coruña, Spain

Received 13 April 2010; Accepted 20 June 2010

Academic Editor: Z. Naor

Copyright © 2010 Moisés Blanco Calvo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. O. Warburg, “On the origin of cancer cells,” Science, vol. 123, no. 3191, pp. 309–314, 1956. View at Scopus
  2. J.-W. Kim and C. V. Dang, “Cancer's molecular sweet tooth and the warburg effect,” Cancer Research, vol. 66, no. 18, pp. 8927–8930, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. J. S. Flier, M. M. Mueckler, P. Usher, and H. F. Lodish, “Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes,” Science, vol. 235, no. 4795, pp. 1492–1495, 1987. View at Scopus
  4. A. Scheepers, H.-G. Joost, and A. Schürmann, “The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function,” Journal of Parenteral and Enteral Nutrition, vol. 28, no. 5, pp. 364–371, 2004. View at Scopus
  5. I. S. Wood and P. Trayhurn, “Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins,” British Journal of Nutrition, vol. 89, no. 1, pp. 3–9, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Uldry and B. Thorens, “The SLC2 family of facilitated hexose and polyol transporters,” Pflugers Archiv European Journal of Physiology, vol. 447, no. 5, pp. 480–489, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. M. L. Macheda, S. Rogers, and J. D. Best, “Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer,” Journal of Cellular Physiology, vol. 202, no. 3, pp. 654–662, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Montel-Hagen, M. Sitbon, and N. Taylor, “Erythroid glucose transporters,” Current Opinion in Hematology, vol. 16, no. 3, pp. 165–172, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. F. Schwartzenberg-Bar-Yoseph, M. Armoni, and E. Karnieli, “The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression,” Cancer Research, vol. 64, no. 7, pp. 2627–2633, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. I. A. Simpson, D. Dwyer, D. Malide, K. H. Moley, A. Travis, and S. J. Vannucci, “The facilitative glucose transporter GLUT3: 20 years of distinction,” American Journal of Physiology, vol. 295, no. 2, pp. E242–E253, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Schmidt, A. Hommel, V. Gawlik et al., “Essential role of glucose transporter GLUT3 for post-implantation embryonic development,” Journal of Endocrinology, vol. 200, no. 1, pp. 23–33, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. C. A. Heyward, T. R. Pettitt, S. E. Leney, G. I. Welsh, J. M. Tavaré, and M. J. O. Wakelam, “An intracellular motif of GLUT4 regulates fusion of GLUT4-containing vesicles,” BMC Cell Biology, vol. 9, article 25, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. D. E. James, R. Brown, J. Navarro, and P. F. Pilch, “Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein,” Nature, vol. 333, no. 6169, pp. 183–185, 1988. View at Scopus
  14. B. B. Kahn, “Alterations in glucose transporter expression and function in diabetes: mechanisms for insulin resistance,” Journal of Cellular Biochemistry, vol. 48, no. 2, pp. 122–128, 1992. View at Scopus
  15. A. Zorzano, W. Wilkinson, N. Kotliar et al., “Insulin-regulated glucose uptake in rat adipocytes is mediated by two transporter isoforms present in at least two vesicle populations,” Journal of Biological Chemistry, vol. 264, no. 21, pp. 12358–12363, 1989. View at Scopus
  16. D. R. Studelska, C. Campbell, S. Pang, K. J. Rodnick, and D. E. James, “Developmental expression of insulin-regulatable glucose transporter GLUT-4,” American Journal of Physiology, vol. 263, no. 1, pp. E102–E106, 1992. View at Scopus
  17. Y. Mitsumoto, E. Burdett, A. Grant, and A. Klip, “Differential expression of the GLUT1 and GLUT4 glucose transporters during differentiation of L6 muscle cells,” Biochemical and Biophysical Research Communications, vol. 175, no. 2, pp. 652–659, 1991. View at Scopus
  18. J. Berger, C. Biswas, P. P. Vicario, H. V. Strout, R. Saperstein, and P. F. Pilch, “Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting,” Nature, vol. 340, no. 6228, pp. 70–72, 1989. View at Scopus
  19. A. G. Douen, T. Ramlal, S. Rastogi et al., “Exercise induces recruitment of the 'insulin-responsive glucose transporter'. Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle,” Journal of Biological Chemistry, vol. 265, no. 23, pp. 13427–13430, 1990. View at Scopus
  20. M. F. Hirshman, L. J. Goodyear, L. J. Wardzala, E. D. Horton, and E. S. Horton, “Identification of an intracellular pool of glucose transporters from basal and insulin-stimulated rat skeletal muscle,” Journal of Biological Chemistry, vol. 265, no. 2, pp. 987–991, 1990. View at Scopus
  21. A. Klip, T. Ramlal, P. J. Bilan, G. D. Cartee, E. A. Gulve, and J. O. Holloszy, “Recruitment of GLUT-4 glucose transporters by insulin in diabetic rat skeletal muscle,” Biochemical and Biophysical Research Communications, vol. 172, no. 2, pp. 728–736, 1990. View at Scopus
  22. X. Wu and H. H. Freeze, “GLUT14, a duplicon of GLUT3, is specifically expressed in testis as alternative splice forms,” Genomics, vol. 80, no. 6, pp. 553–557, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. V. Douard and R. P. Ferraris, “Regulation of the fructose transporter GLUT5 in health and disease,” American Journal of Physiology, vol. 295, no. 2, pp. E227–E237, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Cheeseman, “GLUT7: a new intestinal facilitated hexose transporter,” American Journal of Physiology, vol. 295, no. 2, pp. E238–E241, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Doblado and K. H. Moley, “Facilitative glucose transporter 9, a unique hexose and urate transporter,” American Journal of Physiology, vol. 297, no. 4, pp. E831–E835, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Li, S. Sanna, A. Maschio et al., “The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts,” PLoS Genetics, vol. 3, no. 11, article e194, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Matsuo, T. Chiba, S. Nagamori, et al., “Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia,” American Journal of Human Genetics, vol. 83, no. 6, pp. 744–751, 2008.
  28. H. Matsuo, T. Chiba, S. Nagamori, et al., “Erratum: mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia,” American Journal of Human Genetics, vol. 83, no. 6, p. 795, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. F. Preitner, O. Bonny, A. Laverrière et al., “Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 36, pp. 15501–15506, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Augustin, M. O. Carayannopoulos, L. O. Dowd, J. E. Phay, J. F. Moley, and K. H. Moley, “Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking,” Journal of Biological Chemistry, vol. 279, no. 16, pp. 16229–16236, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Mobasheri, G. Neama, S. Bell, S. Richardson, and S. D. Carter, “Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9,” Cell Biology International, vol. 26, no. 3, pp. 297–300, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. S. A. Evans, M. Doblado, M. M. Chi, J. A. Corbett, and K. H. Moley, “Facilitative glucose transporter 9 expression affects glucose sensing in pancreatic β-cells,” Endocrinology, vol. 150, no. 12, pp. 5302–5310, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Scheepers, S. Schmidt, A. Manolescu et al., “Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue,” Molecular Membrane Biology, vol. 22, no. 4, pp. 339–351, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. R. Augustin, J. Riley, and K. H. Moley, “GLUT8 contains [DE]XXXL[LI] sorting motif and localizes to a late endomosal/lysosomal compartment,” Traffic, vol. 6, no. 12, pp. 1196–1212, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Schmidt, H.-G. Joost, and A. Schürmann, “GLUT8, the enigmatic intracellular hexose transporter,” American Journal of Physiology, vol. 296, no. 4, pp. E614–E618, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. P. A. Dawson, J. C. Mychaleckyj, S. C. Fossey, S. J. Mihic, A. L. Craddock, and D. W. Bowden, “Sequence and functional analysis of GLUT10: a glucose transporter in the type 2 diabetes-linked region of chromosome 20q12-13.1,” Molecular Genetics and Metabolism, vol. 74, no. 1-2, pp. 186–199, 2001. View at Publisher · View at Google Scholar · View at Scopus
  37. G. Andersen, C. S. Rose, Y. H. Hamid et al., “Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits,” Diabetes, vol. 52, no. 9, pp. 2445–2448, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. J. L. Bento, D. W. Bowden, J. C. Mychaleckyj et al., “Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes,” BMC Medical Genetics, vol. 6, article 42, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. W. H. Lin, L. M. Chuang, C. H. Chen et al., “Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population,” Diabetologia, vol. 49, no. 6, pp. 1214–1221, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. K. L. Mohlke, A. D. Skol, L. J. Scott et al., “Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns,” Molecular Genetics and Metabolism, vol. 85, no. 4, pp. 323–327, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. C. S. Rose, G. Andersen, Y. H. Hamid et al., “Studies of relationships between the GLUT10 Ala206Thr polymorphism and impaired insulin secretion,” Diabetic Medicine, vol. 22, no. 7, pp. 946–949, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. P. J. Coucke, A. Willaert, M. W. Wessels et al., “Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome,” Nature Genetics, vol. 38, no. 4, pp. 452–457, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Rogers, M. L. Macheda, S. E. Docherty et al., “Identification of a novel glucose transporter-like protein-GLUT-12,” American Journal of Physiology, vol. 282, no. 3, pp. E733–E738, 2002. View at Scopus
  44. N. M. Gude, J. L. Stevenson, P. Murthi et al., “Expression of GLUT12 in the fetal membranes of the human placenta,” Placenta, vol. 26, no. 1, pp. 67–72, 2005. View at Publisher · View at Google Scholar · View at Scopus
  45. C. A. Stuart, D. Yin, M. E. A. Howell, R. J. Dykes, J. J. Laffan, and A. A. Ferrando, “Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle,” American Journal of Physiology, vol. 291, no. 5, pp. E1067–E1073, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. C. A. Stuart, M. E. A. Howell, Y. Zhang, and D. Yin, “Insulin-stimulated translocation of glucose transporter (GLUT) 12 parallels that of GLUT4 in normal muscle,” Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 9, pp. 3535–3542, 2009. View at Publisher · View at Google Scholar · View at Scopus
  47. M. Uldry, M. Ibberson, J.-D. Horisberger, J.-Y. Chatton, B. M. Riederer, and B. Thorens, “Identification of a mammalian H+-myo-inositol symporter expressed predominantly in the brain,” EMBO Journal, vol. 20, no. 16, pp. 4467–4477, 2001. View at Publisher · View at Google Scholar · View at Scopus
  48. E. Di Daniel, M. H. S. Mok, E. Mead et al., “Evaluation of expression and function of the H+/myo-inositol transporter HMIT,” BMC Cell Biology, vol. 10, article 54, 2009. View at Publisher · View at Google Scholar · View at Scopus
  49. D. M. Parry and P. L. Pedersen, “Intracellular localization and properties of particulate hexokinase in the Novikoff ascites tumor. Evidence for an outer mitochondrial membrane location,” Journal of Biological Chemistry, vol. 258, no. 18, pp. 10904–10912, 1983. View at Scopus
  50. R. Paul, R. Johansson, and P. L. Kellokumpu-Lehtinen, “Tumor localization with 18F-2-fluoro-2-deoxy-d-glucose: comparative autoradiography, glucose 6-phosphatase histochemistry, and histology of renally implanted sarcoma of the rat,” Research in Experimental Medicine, vol. 185, no. 2, pp. 87–94, 1985. View at Scopus
  51. M. M. Graham, A. M. Spence, M. Muzi, and G. L. Abbott, “Deoxyglucose kinetics in a rat brain tumor,” Journal of Cerebral Blood Flow and Metabolism, vol. 9, no. 3, pp. 315–322, 1989. View at Scopus
  52. K. J. Isselbacher, “Sugar and amino acid transport by cells in culture—differences between normal and malignant cells,” The New England Journal of Medicine, vol. 286, no. 17, pp. 929–933, 1972. View at Scopus
  53. J. Yun, C. Rago, I. Cheong et al., “Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells,” Science, vol. 325, no. 5947, pp. 1555–1559, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. A. Behrooz and F. Ismail-Beigi, “Dual control of glut1 glucose transporter gene expression by hypoxia and by inhibition of oxidative phosphorylation,” Journal of Biological Chemistry, vol. 272, no. 9, pp. 5555–5562, 1997. View at Publisher · View at Google Scholar · View at Scopus
  55. R. C. Osthus, H. Shim, S. Kim et al., “Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc,” Journal of Biological Chemistry, vol. 275, no. 29, pp. 21797–21800, 2000. View at Publisher · View at Google Scholar · View at Scopus
  56. V. Ganapathy, M. Thangaraju, and P. D. Prasad, “Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond,” Pharmacology and Therapeutics, vol. 121, no. 1, pp. 29–40, 2009. View at Publisher · View at Google Scholar · View at Scopus
  57. A. Blais, “Expression of Na+-coupled sugar transport in HT-29 cells: modulation by glucose,” American Journal of Physiology, vol. 260, no. 6, pp. C1245–C1252, 1991. View at Scopus
  58. N. Ishikawa, T. Oguri, T. Isobe, K. Fujitaka, and N. Kohno, “SGLT gene expression in primary lung cancers and their metastatic lesions,” Japanese Journal of Cancer Research, vol. 92, no. 8, pp. 874–879, 2001. View at Scopus
  59. V. F. Casneuf, P. Fonteyne, N. Van Damme et al., “Expression of SGLT1, Bcl-2 and p53 in primary pancreatic cancer related to survival,” Cancer Investigation, vol. 26, no. 8, pp. 852–859, 2008. View at Publisher · View at Google Scholar · View at Scopus
  60. Z. Weihua, R. Tsan, W.-C. Huang et al., “Survival of cancer cells is maintained by EGFR independent of its kinase activity,” Cancer Cell, vol. 13, no. 5, pp. 385–393, 2008. View at Publisher · View at Google Scholar · View at Scopus
  61. A. Godoy, V. Ulloa, F. Rodríguez et al., “Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues,” Journal of Cellular Physiology, vol. 207, no. 3, pp. 614–627, 2006. View at Publisher · View at Google Scholar · View at Scopus
  62. N. Suganuma, F. Segade, K. Matsuzu, and D. W. Bowden, “Differential expression of facilitative glucose transporters in normal and tumour kidney tissues,” British Journal of Urology International, vol. 99, no. 5, pp. 1143–1149, 2007. View at Publisher · View at Google Scholar · View at Scopus
  63. A. Ozcan, S. S. Shen, Q. Zhai, and L. D. Truong, “Expression of GLUT1 in primary renal tumors: morphologic and biologic implications,” American Journal of Clinical Pathology, vol. 128, no. 2, pp. 245–254, 2007. View at Publisher · View at Google Scholar · View at Scopus
  64. A. Lidgren, A. Bergh, K. Grankvist, T. Rasmuson, and B. Ljungberg, “Glucose transporter-1 expression in renal cell carcinoma and its correlation with hypoxia inducible factor-1α,” British Journal of Urology International, vol. 101, no. 4, pp. 480–484, 2008. View at Publisher · View at Google Scholar · View at Scopus
  65. J. D. Chandler, E. D. Williams, J. L. Slavin, J. D. Best, and S. Rogers, “Expression and localization of GLUT1 and GLUT12 in prostate carcinoma,” Cancer, vol. 97, no. 8, pp. 2035–2042, 2003. View at Publisher · View at Google Scholar · View at Scopus
  66. T. Kurata, T. Oguri, T. Isobe, S.-I. Ishioka, and M. Yamakido, “Differential expression of facilitative glucose transporter (GLUT) genes in primary lung cancers and their liver metastases,” Japanese Journal of Cancer Research, vol. 90, no. 11, pp. 1238–1243, 1999. View at Scopus
  67. M. Younes, R. W. Brown, M. Stephenson, M. Gondo, and P. T. Cagle, “Overexpression of Glut1 and Glut3 in stage I nonsmall cell lung carcinoma is associated with poor survival,” Cancer, vol. 80, no. 6, pp. 1046–1051, 1997. View at Publisher · View at Google Scholar · View at Scopus
  68. S. Rogers, S. E. Docherty, J. L. Slavin, M. A. Henderson, and J. D. Best, “Differential expression of GLUT12 in breast cancer and normal breast tissue,” Cancer Letters, vol. 193, no. 2, pp. 225–233, 2003. View at Publisher · View at Google Scholar · View at Scopus
  69. S.P. Zamora-León, D. W. Golde, I. I. Concha et al., “Expression of the fructose transporter GLUT5 in human breast cancer,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 5, pp. 1847–1852, 1996. View at Publisher · View at Google Scholar · View at Scopus
  70. S. P. Zamora-Leon, D. W. Golde, I. I. Concha et al., “Erratum: expression of the fructose transporter GLUT5 in human breast cancer,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 26, p. 15522, 1996. View at Scopus
  71. R. S. Brown and R. L. Wahl, “Overexpression of Glut-1 glucose transporter in human breast cancer: an immunohistochemical study,” Cancer, vol. 72, no. 10, pp. 2979–2985, 1993. View at Publisher · View at Google Scholar · View at Scopus
  72. M. Younes, R. W. Brown, D. R. Mody, L. Fernandez, and R. Laucirica, “GLUT1 expression in human breast carcinoma: correlation with known prognostic markers,” Anticancer Research, vol. 15, no. 6, pp. 2895–2898, 1995. View at Scopus
  73. T. Kawamura, T. Kusakabe, T. Sugino et al., “Expression of glucose transporter-1 in human gastric carcinoma: association with tumor aggressiveness, metastasis, and patient survival,” Cancer, vol. 92, no. 3, pp. 634–641, 2001. View at Publisher · View at Google Scholar · View at Scopus
  74. J.-Y. Sung, G. Y. Kim, S.-J. Lim, Y.-K. Park, and Y. W. Kim, “Expression of the GLUT1 glucose transporter and p53 in carcinomas of the pancreatobiliary tract,” Pathology Research and Practice, vol. 206, pp. 24–29, 2010. View at Publisher · View at Google Scholar · View at Scopus
  75. H. Ito, M. Duxbury, M. J. Zinner, S. W. Ashley, and E. E. Whang, “Glucose transporter-1 gene expression is associated with pancreatic cancer invasiveness and MMP-2 activity,” Surgery, vol. 136, no. 3, pp. 548–556, 2004. View at Publisher · View at Google Scholar · View at Scopus
  76. G. Boden, E. Murer, and M. Mozzoli, “Glucose transporter proteins in human insulinoma,” Annals of Internal Medicine, vol. 121, no. 2, pp. 109–112, 1994. View at Scopus
  77. G. Boden, E. Murer, and M. Mozzoli, “Erratum: glucose transporter proteins in human insulinoma,” Annals of Internal Medicine, vol. 121, p. 470, 1994.
  78. R. S. Haber, A. Rathan, K. R. Weiser et al., “GLUT1 glucose transporter expression in colorectal carcinoma: a marker for poor prognosis,” Cancer, vol. 83, no. 1, pp. 34–40, 1998. View at Publisher · View at Google Scholar · View at Scopus
  79. A. Furudoi, S. Tanaka, K. Haruma et al., “Clinical significance of human erythrocyte glucose transporter 1 expression at the deepest invasive site of advanced colorectal carcinoma,” Oncology, vol. 60, no. 2, pp. 162–169, 2001. View at Publisher · View at Google Scholar · View at Scopus
  80. B. L. Ebert, J. D. Firth, and P. J. Ratcliffe, “Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct cis-acting sequences,” Journal of Biological Chemistry, vol. 270, no. 49, pp. 29083–29089, 1995. View at Publisher · View at Google Scholar · View at Scopus
  81. R. Cooper, S. Sarioǧlu, S. Sökmen et al., “Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma?” British Journal of Cancer, vol. 89, no. 5, pp. 870–876, 2003. View at Publisher · View at Google Scholar · View at Scopus
  82. R. J. Boado, K. L. Black, and W. M. Pardridge, “Gene expression of GLUT3 and GLUT1 glucose transporters in human brain tumors,” Molecular Brain Research, vol. 27, no. 1, pp. 51–57, 1994. View at Publisher · View at Google Scholar · View at Scopus
  83. T. Nishioka, Y. Oda, Y. Seino et al., “Distribution of the glucose transporters in human brain tumors,” Cancer Research, vol. 52, no. 14, pp. 3972–3979, 1992. View at Scopus
  84. J. M. Markert, C. M. Fuller, G. Y. Gillespie et al., “Differential gene expression profiling in human brain tumors,” Physiol Genomics, vol. 5, no. 1, pp. 21–33, 2001. View at Scopus
  85. A. Sasaki, H. Yamaguchi, Y. Horikoshi, G. Tanaka, and Y. Nakazato, “Expression of glucose transporter 5 by microglia in human gliomas,” Neuropathology and Applied Neurobiology, vol. 30, no. 5, pp. 447–455, 2004. View at Publisher · View at Google Scholar · View at Scopus
  86. S. Zhou, S. Wang, Q. Wu, J. Fan, and Q. Wang, “Expression of glucose transporter-1 and -3 in the head and neck carcinoma—the correlation of the expression with the biological behaviors,” Journal for Oto-Rhino-Laryngology and Its Related Specialties, vol. 70, no. 3, pp. 189–194, 2008. View at Publisher · View at Google Scholar · View at Scopus
  87. P. Mellanen, H. Minn, R. Grénman, and P. Härkönen, “Expression of glucose transporters in head-and-neck tumors,” International Journal of Cancer, vol. 56, no. 5, pp. 622–629, 1994. View at Scopus
  88. C. Reisser, K. Eichhorn, C. Herold-Mende, A. I. Born, and P. Bannasch, “Expression of facilitative glucose transport proteins during development of squamous cell carcinomas of the head and neck,” International Journal of Cancer, vol. 80, no. 2, pp. 194–198, 1999. View at Publisher · View at Google Scholar · View at Scopus
  89. M. Kunkel, T. E. Reichert, P. Benz et al., “Overexpression of Glut-1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma,” Cancer, vol. 97, no. 4, pp. 1015–1024, 2003. View at Publisher · View at Google Scholar · View at Scopus
  90. U. Tateishi, T. Hasegawa, K. Seki, T. Terauchi, N. Moriyama, and Y. Arai, “Disease activity and 18F-FDG uptake in organising pneumonia: semi-quantitative evaluation using computed tomography and positron emission tomography,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 33, no. 8, pp. 906–912, 2006. View at Publisher · View at Google Scholar · View at Scopus
  91. M. Endo, U. Tateishi, K. Seki et al., “Prognostic implications of glucose transporter protein-1 (Glut-1) overexpression in bone and soft-tissue sarcomas,” Japanese Journal of Clinical Oncology, vol. 37, no. 12, pp. 955–960, 2007. View at Publisher · View at Google Scholar · View at Scopus
  92. N. A. Goldman, E. B. Katz, A. S. Glenn et al., “GLUT1 and GLUT8 in endometrium and endometrial adenocarcinoma,” Modern Pathology, vol. 19, no. 11, pp. 1429–1436, 2006. View at Publisher · View at Google Scholar · View at Scopus
  93. K. Matsuzu, F. Segade, U. Matsuzu, A. Carter, D. W. Bowden, and N. D. Perrier, “Differential expression of glucose transporters in normal and pathologic thyroid tissue,” Thyroid, vol. 14, no. 10, pp. 806–812, 2004. View at Publisher · View at Google Scholar · View at Scopus
  94. X. Jiang, H. Kenerson, L. Aicher et al., “The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake,” American Journal of Pathology, vol. 172, no. 6, pp. 1748–1756, 2008. View at Publisher · View at Google Scholar · View at Scopus
  95. A. L. Edinger, C. M. Linardic, G. G. Chiang, C. B. Thompson, and R. T. Abraham, “Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells,” Cancer Research, vol. 63, no. 23, pp. 8451–8460, 2003. View at Scopus
  96. G. V. Thomas, C. Tran, I. K. Mellinghoff et al., “Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer,” Nature Medicine, vol. 12, no. 1, pp. 122–127, 2006. View at Publisher · View at Google Scholar · View at Scopus
  97. M. Fraenkel, M. Ketzinel-Gilad, Y. Ariav et al., “mTOR inhibition by rapamycin prevents β-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes,” Diabetes, vol. 57, no. 4, pp. 945–957, 2008. View at Publisher · View at Google Scholar · View at Scopus
  98. T. E. Wood, S. Dalili, C. D. Simpson et al., “A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death,” Molecular Cancer Therapeutics, vol. 7, no. 11, pp. 3546–3555, 2008. View at Publisher · View at Google Scholar · View at Scopus
  99. L. G. Melstrom, M. R. Salabat, X.-Z. Ding et al., “Apigenin inhibits the GLUT-1 glucose transporter and the phosphoinositide 3-kinase/akt pathway in human pancreatic cancer cells,” Pancreas, vol. 37, no. 4, pp. 426–431, 2008. View at Publisher · View at Google Scholar · View at Scopus
  100. H. Pelicano, D. S. Martin, R.-H. Xu, and P. Huang, “Glycolysis inhibition for anticancer treatment,” Oncogene, vol. 25, no. 34, pp. 4633–4646, 2006. View at Publisher · View at Google Scholar · View at Scopus
  101. M. K. Gounder, H. Lin, M. N. Stein, S. Goodin, J. R. Bertino, and R. S. DiPaola, “Phase I trial of 2-deoxyglucose for treatment of advanced solid tumors and hormone refractory prostate cancer: a pharmacokinetics (PK) assessment,” in Proceedings of the AACR 101st Annual Meeting, 2010, abstract 2756.
  102. G. Maschek, N. Savaraj, W. Priebe et al., “2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo,” Cancer Research, vol. 64, no. 1, pp. 31–34, 2004. View at Publisher · View at Google Scholar · View at Scopus
  103. K. K. Chan, J. Y. W. Chan, K. K. W. Chung, and K.-P. Fung, “Inhibition of cell proliferation in human breast tumor cells by antisense oligonucleotides against facilitative glucose transporter 5,” Journal of Cellular Biochemistry, vol. 93, no. 6, pp. 1134–1142, 2004. View at Publisher · View at Google Scholar · View at Scopus
  104. T. Mitani, H. Hoshikawa, T. Mori et al., “Growth inhibition of head and neck carcinomas by D-allose,” Head and Neck, vol. 31, no. 8, pp. 1049–1055, 2009. View at Publisher · View at Google Scholar · View at Scopus