International Journal of Endocrinology
Volume 2010 (2010), Article ID 320721, 4 pages
doi:10.1155/2010/320721
Clinical Study

Vitamin D Levels and Lipid Response to Atorvastatin

José Luis Pérez-Castrillón,1,2 Laura Abad Manteca,1 Gemma Vega,1 Javier del Pino Montes,2,3 Daniel de Luis,1,2 and Antonio Dueňas Laita1

1Department Internal Medicine, Rio Hortega Universitary Hospital, C/ Dulzaina 2, University of Valladolid, 47012 Valladolid, Spain
2RETICEF, Spain
3Department of Medicine, Clinic Hospital, University of Salamanca, Spain

Received 9 March 2009; Revised 27 May 2009; Accepted 14 June 2009

Academic Editor: Vin Tangpricha

Copyright © 2010 José Luis Pérez-Castrillón et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Baigent, A. Keech, P. M. Kearney, et al., “Cholesterol Treatment Trialists' (CTT) collaborators: efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 900056 participants in 14 randomised trials of statins,” The Lancet, vol. 366, no. 9493, pp. 1267–1278, 2005.
  2. C. P. Cannon, E. Braunwald, C. H. McCabe, et al., “Intensive versus moderate lipid lowering with statins after acute coronary syndromes,” The New England Journal of Medicine, vol. 350, no. 15, pp. 1495–1504, 2004. View at Publisher · View at Google Scholar · View at PubMed
  3. A. Fahrleitner, H. Dobnig, A. Obermosterer, et al., “Vitamin D deficiency and secondary hyperparathyroidism are common complications in patients with peripheral arterial disease,” Journal of General Internal Medicine, vol. 17, no. 9, pp. 633–639, 2002.
  4. J. L. Perez-Castrillon, G. Vega, L. Abad, et al., “The effects of atorvastatin on vitamin D levels in patients with acute ischemic heart disease,” American Journal of Cardiology, vol. 99, no. 7, pp. 903–905, 2007. View at Publisher · View at Google Scholar · View at PubMed
  5. A. Zittermann, S. S. Schleithoff, and R. Koerfer, “Vitamin D insufficiency in congestive heart failure: why and what to do about it?” Heart Failure Reviews, vol. 11, no. 1, pp. 25–33, 2006. View at Publisher · View at Google Scholar · View at PubMed
  6. Y. C. Li, “Vitamin D regulation of the renin-angiotensin system,” Journal of Cellular Biochemistry, vol. 88, no. 2, pp. 327–331, 2003. View at Publisher · View at Google Scholar · View at PubMed
  7. C. M. Ferrario and W. B. Strawn, “Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease,” American Journal of Cardiology, vol. 98, no. 1, pp. 121–128, 2006. View at Publisher · View at Google Scholar · View at PubMed
  8. K. E. Thummel, C. Brimer, K. Yasuda, et al., “Transcriptional control of intestinal cytochrome P4503A by 1alpha,25-dihydroxy vitamin D3,” Molecular Pharmacology, vol. 6, no. 6, pp. 1399–1406, 2001.
  9. S. Sans, A. P. Fitzgerald, D. Roys, R. Conroy, and I. Graham, “Calibration de la tabla Score de riesgo vascular para Espana,” Revista Española de Cardiología, vol. 60, no. 5, pp. 476–485, 2007.
  10. A. W. Norman, “From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health,” American Journal of Clinical Nutrition, vol. 88, no. 2, pp. 491S–499S, 2008.
  11. D. H. Kim, S. Sabour, U. N. Sagar, S. Adams, and D. J. Whellan, “Prevalence of hypovitaminosis D in cardiovascular diseases (from the National Health and Nutrition Examination Survey 2001 to 2004),” American Journal of Cardiology, vol. 102, no. 11, pp. 1540–1544, 2008. View at Publisher · View at Google Scholar · View at PubMed
  12. H. Lennernas, “Clinical pharmacokinetics of atorvastatin,” Clinical Pharmacokinetics, vol. 42, no. 13, pp. 1141–1160, 2003.
  13. M. F. Holick, “Vitamin D deficiency,” The New England Journal of Medicine, vol. 357, no. 3, pp. 266–281, 2007.
  14. R. P. Gupta, Y. A. He, K. S. Patrick, J. R. Halpert, and N. H. Bell, “CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 2, pp. 1210–1219, 2005. View at Publisher · View at Google Scholar · View at PubMed
  15. W. Jacobsen, B. Kuhn, A. Soldner, et al., “Lactonization is the critical first step in the disposition of the 3-hydroxy-3- methylglutarylCoA reductase inhibitor atorvastatin,” Drug Metabolism and Disposition, vol. 28, no. 11, pp. 1369–1378, 2000.
  16. J. B. Schwartz, “Effects of vitamin D supplementation in atorvastatin-treated patients: a new drug interaction with an unexpected consequence,” Clinical Pharmacology and Therapeutics, vol. 85, no. 2, pp. 198–203, 2009. View at Publisher · View at Google Scholar · View at PubMed
  17. R. Defay, M. E. Astruc, S. Roussillon, B. Descamps, and A. Crastes de Paulet, “DNA synthesis and 3-hydroxy-3-methylglutarylCoA reductase activity in PHA-stimulated human lymphocytes: a comparative study of the inhibitory effects of some oxyterols with special reference to side chain hydroxylated derivatives,” Biochemestry Biophysics Research Communication, vol. 106, no. 2, pp. 362–372, 1982.
  18. A. K. Gupta, R. C. Sexton, and H. Rudney, “Effect of vitamin D 3 derivatives on cholesterol synthesis and HMG-CoA reductase activity in cultured cells,” Journal of Lipid Research, vol. 30, no. 3, pp. 379–386, 1989.
  19. H. Wilczek, J. Sobra, V. Justova, et al., “Iatropathogenic effect of MEVACOR on vitamin D metabolism,” Casopís Lekaru Ceskych, vol. 128, no. 40, pp. 1254–1256, 1989.
  20. H. Wilzcek, J. Sobra, R. Ceska, et al., “Monitoring plasma levels of vitamin D metabolites in simvastatin therapy in patients with familial hypercholesterolemia,” Casopís Lekaru Ceskych, vol. 133, no. 23, pp. 727–729, 1994.
  21. P. Lips, “Vitamin D physiology,” Progress in Biophysics and Molecular Biology, vol. 92, no. 1, pp. 4–8, 2006.
  22. S. Pilz, W. März, B. Wellnitz, et al., “Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 10, pp. 3927–3935, 2008. View at Publisher · View at Google Scholar · View at PubMed
  23. J. H. Lee, J. H. O'Keefe, D. Bell, D. D. Hensrud, and M. F. Holick, “Vitamin D deficiency. An important, common, and easily treatable cardiovascular risk factor?” Journal of the American College of Cardiology, vol. 52, no. 24, pp. 1949–1956, 2008. View at Publisher · View at Google Scholar · View at PubMed