- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
International Journal of Endocrinology
Volume 2010 (2010), Article ID 519607, 7 pages
Increased Daytime Sleepiness in Patients with Childhood Craniopharyngioma and Hypothalamic Tumor Involvement: Review of the Literature and Perspectives
Department of Paediatrics and Paediatric Hematology and Oncology, Klinikum Oldenburg, Rahel-Straus-Straße 10, 26133 Oldenburg, Germany
Received 29 April 2010; Revised 16 August 2010; Accepted 5 October 2010
Academic Editor: Jessica A. Mong
Copyright © 2010 Hermann L. Müller. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Childhood craniopharyngiomas are rare embryogenic malformations of the sellar region, presumably derived from Rathke cleft epithelium. The overall survival rates after neurosurgical intervention and/or irradiation are high (92%). However, the quality of survival is frequently impaired due to endocrine deficiencies, sleep disturbances, daytime sleepiness, and severe obesity caused by hypothalamic lesions. Based on self-assessment using nutritional diaries, caloric intake was similar in patients and BMI-matched controls. Analyses of physical activity by accelerometric measurements showed a markedly lower level of physical activity. Significant daytime sleepiness and disturbances of circadian rhythms have been demonstrated in obese childhood craniopharyngioma patients. Daytime sleepiness and obesity in these patients were both correlated with low nocturnal and early morning melatonin levels. Polysomnographic studies in patients with severe daytime sleepiness revealed sleeping patterns typical for secondary narcolepsy. Reports on a beneficial effect of treatment with central stimulating agents supported the hypothesis that secondary narcolepsy should be considered as a rare cause for severe daytime sleepiness in patients with childhood craniopharyngioma.
Craniopharyngiomas are embryogenic malformations of low histological malignancy (WHO I°), which arise from ectoblastic remnants of Rathke’s pouch and can be found anywhere along the path of development of Rathke’s pouch in hypothalamic and pituitary regions, both of importance in endocrine regulation and satiety modulation . Craniopharyngiomas are the most common intracranial tumors of nonglial origin in the pediatric population, constituting between 1.2 to 4% of all brain tumors and 6 to 9% of pediatric brain tumors. Overall there are 0.5 to 2 new cases per million population occurring each year, 30 to 50% of which are children and adolescents . The peak incidence is at age 5 to 10 years, but they can occur at any age including infancy and pre- and neonatal period .
Whereas the childhood form of craniopharyngioma mainly presents with an adamantinous histology, the adult type of craniopharyngioma occurs at a peak age of 50–75 years and presents mainly with papillary histology. Other tumors with similar localization but different characteristics on magnetic resonance imaging (MRI) are germinoma, germ cell tumours, langerhans cell histiocytosis, and pilocytic astrocytoma .
Headaches, visual disturbances, polyuria, reduced growth rates, and weight gain are frequently the first symptoms in the history of patients with childhood craniopharyngioma [7, 8]. The clinical features at the time of diagnosis of craniopharyngioma during childhood are usually unspecific signs of increased intracranial pressure. Major symptoms are headaches, impaired vision (62–84%, primarily in adults), and endocrine failures (52–87%, primarily in children). Chiasmatic involvement may be attended by defects of vision and visual fields. Endocrine deficiencies affect the hypothalamic-pituitary axes for growth hormone (75%), gonadotrophins (40%), ACTH (25%), and thyroid-stimulating hormone (TSH) (25%). 17% of the children with craniopharyngioma present with diabetes insipidus prior to surgery .
The therapeutic goal is first to relieve symptoms by urgent surgical decompression and second to achieve an early long-term cure by complete resection but without causing further damage to the hypothalamus or optic tract. Postoperative sequelae are deemed unacceptable in patients with preoperatively intact function. However, the optimal primary therapeutic strategy to achieve the correct balance between late sequelae and successful cure remains unknown. Even after complete surgical resection, craniopharyngioma relapses occur in up to 17% of patients . With radical resection, the risk of hypothalamic damage is considerable, especially in craniopharyngioma with suprasellar extension to the hypothalamic area. The appropriate time point of irradiation in patients with residual tumor after incomplete resection is controversial as well [10–13].
Although the tumor itself is low-grade histological malignancy and the overall survival rate (92%) of patients is high , there is considerable morbidity even when the tumor can be completely resected [5, 7, 9, 10, 14–24]. Childhood craniopharyngioma patients often suffer sequelae of severe obesity. Increased body weight in patients at risk for the development of severe obesity during followup is already detectable at the time of diagnosis of craniopharyngioma . Patients who developed severe obesity presented with a higher body mass index SDS  already at the time of diagnosis when compared with patients who kept their normal weight. The evaluation of the patients’ history  and anthropometric data collected before diagnosis  confirmed the observation, that pathogenic mechanisms for the development of later obesity have significant impact on weight already at the time of diagnosis before initiation of therapy. Hypothalamic involvement of craniopharyngioma is the most important risk factor for the development of obesity before and after tumor diagnosis (Figure 1) [9, 10, 15–17, 19, 25].
In spite of hormonal substitution, the management of hypothalamic injury-induced hyperphagia is difficult and severe obesity occurs postoperatively in up to 52% of patients with at least one half of these patients having extreme difficulty controlling their desire to eat [9, 24]. Severe obesity has major negative impact on quality of life in survivors of childhood craniopharyngioma [8, 10, 14, 16, 17, 19, 24]. Conventional strategies for weight control are less efficient because of impaired physical activity due to attendant neurological and visual deficits and the complaint of increased daytime sleepiness.
A German multicenter study on childhood craniopharyngioma patients suggested a secondary hypothalamic disorder as pathogenic factor in patients at risk for severe obesity and increased daytime sleepiness . Müller et al. surveyed a large group of patients with childhood craniopharyngioma and hypothalamic astrocytoma for daytime sleepiness using the German version of the Epworth Sleepiness Scale (ESS) . About 1/3 of the patients reported increased daytime sleepiness, characterized by an ESS score above 10. The severity of their daytime sleepiness was unexpectedly high, especially in obese patients with a BMI > 4 SD .
Sleep regulation and circadian rhythms are at least partially mediated by hypothalamic structures, for example, the suprachiasmatic nucleus, regulating melatonin secretion . The secretion of melatonin, a pineal indoleamine, occurs during hours of darkness and as it affects sleep patterns it has been tried in treating jet lag and other disorders from delay of sleep because of its possible role in influencing circadian rhythm. Because a destruction or dysfunction of the suprachiasmatic nucleus seems likely in many craniopharyngioma patients with suprasellar tumor extension , Müller et al. compared melatonin secretion in severely obese, obese, and in nonobese craniopharyngioma patients . To analyze the influence of obesity and hypothalamic lesions on melatonin secretion, patients with hypothalamic tumors (pilocytic astrocytomas) and obese and normal weight control subjects were also analyzed. The authors compared salivary melatonin concentrations at morning, midday, evening, and nighttime among severely obese, obese, and nonobese patients and normal controls. Salivary melatonin concentrations correlate with melatonin concentrations in plasma [29, 30].
Whereas several studies [31–33] on different patient cohorts have found no significant relation between melatonin secretion and obesity, Birketvedt et al.  reported on a rare night eating syndrome characterized by frequent awakening at night, higher nocturnal energy intake, and attenuation of nocturnal rise in plasma melatonin. As hypothesized based on hypothalamic disorders in the severely obese craniopharyngioma patients, decreased melatonin concentrations at nighttime were detected in patients analyzed by Müller et al.  (Figures 2(a), 2(b)). The authors speculated that the diurnal rhythm of melatonin was suppressed in obese patients with hypothalamic tumors as craniopharyngioma or pilocytic astrocytoma. As cortisol may also influence wakefulness, salivary cortisol concentrations were compared in all groups to exclude confounding effects. No differences for cortisol serum concentrations were found among the groups. The significant negative correlations between salivary melatonin concentrations in the morning and at nighttime and the ESS scores indicate that reduced nocturnal melatonin secretion may lead to increased daytime sleepiness in patients with childhood craniopharyngioma. The findings suggested that increased daytime sleepiness in patients with childhood craniopharyngioma was associated with decreased nocturnal melatonin levels, which were related to the degree of obesity and the tumor diagnosis. First promising experiences on experimental substitution of melatonin in obese patients with craniopharyngioma supported the hypothesis that increased daytime sleepiness is associated with reduced nocturnal melatonin secretion .
The observations confirmed previous reports on agedependency of melatonin secretion . However, in spite of the fact that age-dependent effects were found similarly in all analyzed subgroups and the agedependency had no statistical impact on reported differences in terms of craniopharyngioma-associated melatonin depression, it has to be stated that the preliminary results have to be confirmed by prospective analysis of larger cohorts with more homogeneous agedistribution. Further studies on the hypothesis are part of the German prospective multicenter study KRANIOPHARYNGEOM 2007 on patients with childhood craniopharyngioma [10, 36]. As it has been reported  that hypothalamic damage is a risk factor for severe obesity in craniopharyngioma patients, it can be speculated that hypothalamic damage could have been responsible for disturbances in melatonin secretion. This speculation is supported by similar findings for patients with hypothalamic tumors of other histology such as pilocytic astrocytoma .
Studies on physical activity using accelerometric analysis of movement counts revealed that physical activity was reduced in the group of craniopharyngioma patients with obesity and hypothalamic involvement when compared with age and BMI-matched controls . Caloric intake was similar in normal controls (1027 healthy nonobese subjects, representative sample of the 7 to 16 year-old German population with an age distribution: years) and craniopharyngioma patients (27 patients, age distribution: years) and had no significant impact on the degree of obesity and the physical activity in analyzed cohorts . Hypothalamic involvement of craniopharyngioma had major negative impact on functional capacity and quality of life and was a major risk factor for the development of severe obesity in survivors of childhood craniopharyngioma [5, 7–10, 14–21].
Reports [5, 22, 25] on increased daytime sleepiness and reduced physical activity in patients with craniopharyngioma support the hypothesis that physical activity might be decreased in these patients due to yet unknown neuroendocrine disorders. On the other hand, sleep at night was severely disturbed in many patients with increased daytime sleepiness . Accordingly, Müller et al. analyzed daytime sleepiness and polysomnographic patterns in patients with childhood craniopharyngioma in order to define further risk factors for severe obesity.
Since sleep regulation and circadian rhythms are at least partially mediated by hypothalamic structures, for example, the suprachiasmatic nucleus, Müller et al. conducted a two-night polysomnography (PSG) and a multiple sleep latency test (MSLT) consisting of four or five 20-minute naps with nine obese craniopharyngioma patients and one patient with an astrocytoma of the pituitary stalk displaying acute daytime sleepiness . The MSLT was developed to render a better diagnostic sensitivity and specificity in the diagnosis, and usually two or more SOREMP in the MSLT are regarded as necessary for the diagnosis. Usually a mean sleep latency of <5 minutes should be observed for the diagnosis of narcolepsy. The diagnostic validity of MSLT in early infancy is controversial. However, the youngest patient included in our MSLT analyses was 10 years of age . Only two patients showed an obstructive sleep apnea syndrome (OSAS), the usual sleep-related disorder in acutely obese patients. However, seven patients fulfilled the classic PSG criteria for secondary narcolepsy or hypersomnia. These results were unexpected since none of the patients complained of cataplexy, hypnagogic hallucinations, or sleep paralysis on inquiry. What is particularly noteworthy is that recent research has suggested a hypothalamic disorder in narcolepsy. A defect in the orexin II receptor is responsible for canine narcolepsy  and orexin knockout mice show characteristic features of narcolepsy . Orexin is expressed exclusively in the lateral hypothalamus, and the orexin receptors seem to be wider spread . In human narcoleptics, 8 of 10 had orexin A below the detection limit of the assay used . Despite excessive research in this field, only one patient could be identified with a genetic defect in the orexin system . In autopsy of narcoleptic patients, the lack of orexin neurons in the lateral hypothalamus was observed in 10 cases [41, 42].
It has also been reported that systemic administration of orexin relieves narcoleptic symptoms in dogs [43, 44]. The peculiar finding that sleep and sleep attacks in narcoleptic patients are initiated by a sleep onset REM period (SOREMP) was recognized in the early 1960s . Since then, this PSG finding is regarded as a phenomenon occurring almost exclusive in narcolepsy, although there are some descriptions of SOREM in subjects without narcolepsy. García-Borreguero et al.  reported that glucocorticoid replacement therapy in Addison’s patients was permissive for decreased REM latency when hydrocortisone was taken at bedtime. MSLT was not performed in this study. All patients with SOREM were under treatment with hydrocortisone replacement therapy in the study of Müller et al. . However, hydrocortisone replacement treatment alone cannot explain the excessive daytime sleepiness in analyzed patients as this is standard treatment for craniopharyngioma patients, including those not suffering severe daytime sleepiness.
Secondary narcolepsy is a rare disorder. However, several case reports were published on secondary narcolepsy, mainly reporting on patients with tumorous conditions in the hypothalamic area [47, 48]. Diagnostic criteria vary, but all patients presented with hypersomnia as a leading pathology. Interestingly, the majority of reported patients show hypersomnia, but not cataplexy, hallucinations, or sleep paralysis. In fact, a medline search yielded over 30 cases of secondary narcolepsy without cataplexy during the last 50 years, but yielded only 13 cases with secondary cataplexy. These cases are surprisingly very heterogenic and only two cases had tumors in the area of the hypothalamus , two cases had tumors in the brain stem pontomedullary astrocytoma , glioblastoma of rostral brain stem , one patient had a frontal lobe tumor , five patients had meningioma , and five patients had meningeal carcinomatosis .
Not all patients with a tumorous condition in the hypothalamic area suffer from hypersomnia, and even less from cataplexy. This is surprising, since deficiency of orexin is regarded as the cause of hypersomnia and cataplexy in idiopathic narcolepsy. Cases with secondary cataplexy in the literature seem to have more widespread tumor disease than cases with secondary hypersomnia. This leads to speculation that there must be some other pathology operating in addition to orexin deficiency to produce cataplexy in idiopathic narcolepsy. This hypothesis is supported by the fact that some patients with clear idiopathic narcolepsy and cataplexy have normal orexin levels in cerebrospinal fluid .
In concert with findings [5, 20] suggesting that increased daytime sleepiness is a common complaint in patients with childhood craniopharyngioma and that the incidence seems to be equal in obese and normal weight patients, reported results  together with current research on narcolepsy lead to the conclusion that secondary hypersomnia and secondary narcolepsy may be contributing causes for increased daytime sleepiness and weight control difficulties in obese craniopharyngioma patients. Preliminary positive experiences with central stimulating agent treatment (Modafinil or Methylphenidate) in patients with childhood craniopharyngioma and secondary narcolepsy support this speculation [22, 55].
Based on the literature [56, 57], radical surgery with potential damage to hypothalamic structures and consecutive increased daytime sleepiness is no appropriate treatment strategy in patients with hypothalamic involvement of childhood craniopharyngioma. For such patients innovative treatment strategies are warranted after incomplete resection. Accordingly, in KRANIOPHARYNGEOM 2007 quality of life, event-free survival and overall survival rates in patients (age ≥5 years at diagnosis and at incomplete resection) are currently analyzed after randomization of the time point of irradiation after incomplete resection (immediate irradiation versus irradiation at progression of residual tumor). The schedule of prospective data collection and the set and definition of parameters is based on a European consensus . Standardized European data sets on a rare disease such as childhood craniopharyngioma should help to increase cohort sizes and facilitate common data evaluation . Hopefully, this international study will lead to treatment recommendations that prevent severe sequelae such as increased daytime sleepiness and secondary narcolepsy in patients with childhood craniopharyngioma.
The studies were supported by a grant of Deutsche Kinderkrebsstiftung, Bonn, Germany. The author is very grateful to Mrs. Ursel Gebhardt for her help in preparing the paper.
- S. L. Einhaus and R. A. Sanford, “Craniopharyngiomas,” in Principles and practice of Pediatric Neurosurgery, A. L. Albright, I. F. Pollack, and P. D. Adelson, Eds., pp. 545–562, Thieme, New York, NY, USA, 1999.
- G. R. Bunin, T. S. Surawicz, P. A. Witman, S. Preston-Martin, F. Davis, and J. M. Bruner, “The descriptive epidemiology of craniopharyngioma,” Journal of Neurosurgery, vol. 89, no. 4, pp. 547–551, 1998.
- J. Müller-Scholden, T. Lehrnbecher, H. L. Müller et al., “Radical surgery in a neonate with craniopharyngioma: report of a case,” Pediatric Neurosurgery, vol. 33, no. 5, pp. 265–269, 2000.
- M. F. Rolland-Cachera, T. J. Cole, M. Sempe, J. Tichet, C. Rossignol, and A. Charraud, “Body mass index variations: centiles from birth to 87 years,” European Journal of Clinical Nutrition, vol. 45, no. 1, pp. 13–21, 1991.
- H. L. Müller, G. Handwerker, B. Wollny, A. Faldum, and N. Sörensen, “Melatonin secretion and increased daytime sleepiness in childhood craniopharyngioma patients,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 8, pp. 3993–3996, 2002.
- M. Warmuth-Metz, A. K. Gnekow, H. Müller, and L. Solymosi, “Differential diagnosis of suprasellar tumors in children,” Klinische Padiatrie, vol. 216, no. 6, pp. 323–330, 2004.
- H. L. Müller, U. Gebhardt, S. Schröder et al., “Analyses of treatment variables for patients with childhood craniopharyngioma—results of the ulticenter prospective trial KRANIOPHARYNGEOM 2000 after three years of follow-up,” Hormone Research in Paediatrics, vol. 73, no. 3, pp. 175–180, 2010.
- H. L. Müller, “Childhood craniopharyngioma: recent advances in diagnosis, treatment and follow-up,” Hormone Research, vol. 69, no. 4, pp. 193–202, 2008.
- H. L. Müller, K. Bueb, U. Bartels et al., “Obesity after childhood craniopharyngioma—German multicenter study on pre-operative risk factors and quality of life,” Klinische Padiatrie, vol. 213, no. 4, pp. 244–249, 2001.
- H. L. Müller, U. Gebhardt, F. Pohl et al., “High rates of early relapses after complete resection and early progressions after incomplete resection of childhood craniopharyngioma-update on KRANIOPHARYNGEOM 2000 and design of KRANIOPHARYNGEOM 2007,” Klinische Padiatrie, vol. 218, no. 6, pp. 315–320, 2006.
- G. Becker, R. D. Kortmann, M. Skalej, and M. Bamberg, “The role of radiotherapy in the treatment of craniopharyngeoma – indications, results, side effects,” in Controversies in Neuro-Oncology, T. Wiegel, T. Hinkelbein, M. Brock, and T. Hoell, Eds., vol. 33 of Frontiers of Radiation Therapy and Oncology, pp. 100–113, Karger, Basel, witzerland, 1999.
- H. L. Müller, “More or less? Treatment strategies in childhood craniopharyngioma,” Child's Nervous System, vol. 22, no. 2, pp. 156–157, 2006.
- H. L. Müller, A. Albanese, G. Calaminus et al., “Consensus and perspectives on treatment strategies in children craniopharyngioma: results of a meeting of the Craniopharyngioma Study Group (SIOP), Genova, 2004,” Journal of Pediatric Endocrinology and Metabolism, vol. 19, no. 1, pp. 453–454, 2006.
- H. L. Müller, G. Bruhnken, A. Emser et al., “Longitudinal study on quality of life in 102 survivors of childhood craniopharyngioma,” Child's Nervous System, vol. 21, no. 11, pp. 975–980, 2005.
- H. L. Müller, A. Emser, A. Faldum et al., “Longitudinal study on growth and body mass index before and after diagnosis of childhood craniopharyngioma,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 7, pp. 3298–3305, 2004.
- H. L. Müller, U. Gebhardt, N. Etavard-Gorris et al., “Prognosis and sequela in patients with childhood craniopharyngioma - Results of HIT-ENDO and update on KRANIOPHARYN-GEOM 2000,” Klinische Padiatrie, vol. 216, no. 6, pp. 343–348, 2004.
- H. L. Müller, A. Faldum, N. Etavard-Gorris et al., “Functional capacity, obesity and hypothalamic involvement: cross-sectional study on 212 patients with childhood craniopharyngioma,” Klinische Padiatrie, vol. 215, no. 6, pp. 310–314, 2003.
- H. L. Müller, U. Gebhardt, N. Etavard-Gorris, R. Kolb, M. Warmuth-Metz, and N. Sorensen, “Current strategies in diagnostics and endocrine treatment of patients with childhood craniopharyngioma during follow-up—recommendations in KRANIOPHARYNGEOM 2000,” Onkologie, vol. 28, no. 3, pp. 150–156, 2005.
- H. L. Müller, U. Gebhardt, A. Faldum et al., “Functional capacity and body mass index in patients with sellar masses—cross-sectional study on 403 patients diagnosed during childhood and adolescence,” Child's Nervous System, vol. 21, no. 7, pp. 539–545, 2005.
- H. L. Müller, G. Handwerker, U. Gebhardt et al., “Melatonin treatment in obese patients with childhood craniopharyngioma and increased daytime sleepiness,” Cancer Causes and Control, vol. 17, no. 4, pp. 583–589, 2006.
- H. L. Müller, M. Heinrich, K. Bueb et al., “Perioperative dexamethasone treatment in childhood craniopharyngioma—influence on short-term and long-term weight gain,” Experimental and Clinical Endocrinology and Diabetes, vol. 111, no. 6, pp. 330–334, 2003.
- H. L. Müller, S. Müller-Stöver, U. Gebhardt, R. Kolb, N. Sörensen, and G. Handwerker, “Secondary narcolepsy may be an underrated cause of increased daytime sleepiness in obese patients after childhood craniopharyngioma,” Journal of Pediatric Endocrinology & Metabolism, vol. 19, pp. 423–429, 2006.
- H. L. Müller, P. Schneider, K. Bueb et al., “Volumetric bone mineral density in patients with childhood craniopharyngioma,” Experimental and Clinical Endocrinology and Diabetes, vol. 111, no. 3, pp. 168–173, 2003.
- C. L. Roth, U. Gebhardt, and H. L. Müller, “Appetite-regulating hormone changes in patients with craniopharyngioma,” Obesity. In press.
- K. J. Harz, H. L. Müller, E. Waldeck, V. Pudel, and C. Roth, “Obesity in patients with craniopharyngioma: assessment of food intake and movement counts indicating physical activity,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 11, pp. 5227–5231, 2003.
- K. E. Bloch, O. D. Schoch, J. N. Zhang, and E. W. Russi, “German version of the Epworth Sleepiness Scale,” Respiration, vol. 66, no. 5, pp. 440–447, 1999.
- A. Brzezinski, “Melatonin in humans,” New England Journal of Medicine, vol. 336, no. 3, pp. 186–195, 1997.
- F. G. Flynn, J. L. Cummings, and U. Tomiyasu, “Altered behavior associated with damage to the ventromedial hypothalamus: a distinctive syndrom,” Behavioral Neurology, pp. 49–58, 1988.
- M.-L. Laakso, T. Porkka-Heiskanen, A. Alila, D. Stenberg, and G. Johansson, “Correlation between salivary and serum melatonin: dependence on serum melatonin levels,” Journal of Pineal Research, vol. 9, no. 1, pp. 39–50, 1990.
- G. M. Vaughan, “New sensitive serum melatonin radioimmunoassay employing the Kennaway G280 antibody: Syrian hamster morning adrenergic response,” Journal of Pineal Research, vol. 15, no. 2, pp. 88–103, 1993.
- J.-I. Murata, Y. Sawamura, J. Ikeda, S. Hashimoto, and K.-I. Honma, “Twenty-four hour of melatonin in patients with a history of pineal and/or hypothalamo-neurohypophyseal germinoma,” Journal of Pineal Research, vol. 25, no. 3, pp. 159–166, 1998.
- Z. Ostrowska, B. Buntner, I. Banas, B. Kos-Kudla, B. Marek, and K. Zwirska-Korczala, “Circadian variations of salivary melatonin levels in women of reproductive and postmenopausal age with gynoid and android obesity,” Endocrine Regulations, vol. 30, no. 3, pp. 143–152, 1996.
- L. Tamarkin, P. Abastillas, and H. C. , “The daily profile of plasma melatonin in obese and Prader-Willi syndrome children,” Journal of Clinical Endocrinology and Metabolism, vol. 55, no. 3, pp. 491–495, 1982.
- G. S. Birketvedt, J. Florholmen, J. Sundsfjord et al., “Behavioral and neuroendocrine characteristics of the night-eating syndrome,” Journal of the American Medical Association, vol. 282, no. 7, pp. 657–663, 1999.
- F. Waldhauser, B. Ehrhart, and E. Forster, “Clinical aspects of the melatonin action: impact of development, aging, and puberty,” Experientia, vol. 49, no. 8, pp. 671–681, 1993.
- H. L. Müller, “Childhood craniopharyngioma—current controversies on management in diagnostics, teratment and follow-up,” Expert Review of Neurotherapeutics, vol. 10, no. 4, pp. 515–524, 2010.
- L. Lin, J. Faraco, R. Li et al., “The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene,” Cell, vol. 98, no. 3, pp. 365–376, 1999.
- R. M. Chemelli, J. T. Willie, C. M. Sinton et al., “Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation,” Cell, vol. 98, no. 4, pp. 437–451, 1999.
- D. Wagner, R. Salin-Pascual, M. A. Greco, and P. J. Shiromani, “Distribution of hypocretin-containing neurons in the lateral hypothalamus and c-Fos-immunoreactive neurons in the VLPO,” Sleep Research Online, vol. 3, no. 1, pp. 35–42, 2000.
- S. Nishino, B. Ripley, S. Overeem, G. J. Lammers, and E. Mignot, “Hypocretin (orexin) deficiency in human narcolepsy,” Lancet, vol. 355, no. 9197, pp. 39–40, 2000.
- C. Peyron, J. Faraco, W. Rogers et al., “A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains,” Nature Medicine, vol. 6, no. 9, pp. 991–997, 2000.
- T. C. Thannickal, R. Y. Moore, R. Nienhuis et al., “Reduced number of hypocretin neurons in human narcolepsy,” Neuron, vol. 27, no. 3, pp. 469–474, 2000.
- J. John, M.-F. Wu, and J. M> Siegel, “Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs,” Sleep Research Online, vol. 3, no. 1, pp. 2823–2825, 2002.
- C. L. Marcus, W. H. Trescher, A. C. Halbower, and J. Lutz, “Secondary narcolepsy in children with brain tumors,” Sleep, vol. 25, no. 4, pp. 435–439, 2002.
- A. Rechtschaffen and A. Kales, A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects, Brain Information Service/Brain Research Institute, Los Angeles, Calif, USA, 1968.
- D. García-Borreguero, T. A. Wehr, O. Larrosa et al., “Glucocorticoid replacement is permissive for rapid eye movement sleep and sleep consolidation in patients with adrenal insufficiency,” Journal of Clinical Endocrinology and Metabolism, vol. 85, no. 11, pp. 4201–4206, 2000.
- L. E. Krahn, B. F. Boeve, L. Oliver, and M. H. Silber, “Hypocretin (orexin) and melatonin values in a narcoleptic-like sleep disorder after pinealectomy,” Sleep Medicine, vol. 3, no. 6, pp. 521–523, 2002.
- C. L. Marcus, W. H. Trescher, A. C. Halbower, and J. Lutz, “Secondary narcolepsy in children with brain tumors,” Sleep, vol. 25, no. 4, pp. 435–439, 2002.
- M. Anderson and M. V. Salmon, “Symptomatic cataplexy,” Journal of Neurology Neurosurgery and Psychiatry, vol. 40, no. 2, pp. 186–191, 1977.
- O. F. D'Cruz, B. V. Vaughn, S. H. Gold, and R. S. Greenwood, “Symptomatic cataplexy in pontomedullary lesions,” Neurology, vol. 44, no. 11, pp. 2189–2191, 1994.
- S. M. Stahl, R. B. Layzer, and M. J. Aminoff, “Continuous cataplexy in a patient with a midbrain tumor: the limp man syndrome,” Neurology, vol. 30, no. 10, pp. 1115–1118, 1980.
- S. Ethelberg, “On cataplexy in a case of frontal lobe tumour,” Acta Psychiatrica et Neurologica, vol. 24, no. 3-4, pp. 421–427, 1949.
- T. Smith, “Cataplexy in association with meningeomas,” Acta Neurologica Scandinavica. Supplementum, vol. 67, no. 94, pp. 45–47, 1983.
- S. Minami, M. Asai, K. Iwahori, T. Utsumi, T. Kido, and K. Kiyoshi, “Three cases of metastatic meningeal carcinomatosis from lung cancer,” Nihon Kokyuki Gakkai Zasshi, vol. 40, no. 6, pp. 513–519, 2002.
- P. W. Mason, N. Krawiecki, and L. R. Meacham, “The use of dextroamphetamine to treat obesity and hyperphagia in children treated for craniopharyngioma,” Archives of Pediatrics and Adolescent Medicine, vol. 156, no. 9, pp. 887–892, 2002.
- H. L. Müller and N. Sörensen, Eds., “KRANIOPHARYNGEOM 2000—prospective, multicenter surveillance study of children and adolescents with craniopharyngioma,” Universitätsverlag Aschenbeck & Isensee, Oldenburg 2001, www.kraniopharyngeom.net.
- H. L. Müller, “Craniopharyngioma—current concepts in diagnosis, therapy and follow-up,” Nature Review Endocrinology, vol. 6, no. 11, pp. 609–618, 2010.