Vitamin D Receptor Activation Mitigates the Impact of Uremia on Endothelial Function in the 5/6 Nephrectomized Rats
Figure 4
Cinacalcet suppressed PTH, but did not improve endothelial dysfunction in 5/6 nephrectomized rats. SHAM and 5/6 NX rats were treated with vehicle or cinacalcet as described in “Materials and Methods” ( = 8 per group). On Days 0 and 13 (2 hours after the drug treatment), blood samples were collected for blood chemistry and PTH. Aortic rings were precontracted with phenylephrine (PE, 3 M), and the endothelium-dependent vasodilator acetylcholine was added in half-log increments (1 nM–30 M) at 3–5 minute intervals. Afterwards, aortic rings were precontracted with PE (3 M) and subsequently treated with endothelial-independent vasodilator sodium nitroprusside (SNP, 1 nM–1 M) at 3–5 minute intervals. (a) Serum PTH. (b) Serum Ca. (c) Acetylcholine-evoked relaxation. (d) SNP-evoked relaxation.
