Vitamin D Pathway Genes, Diet, and Risk of Renal Cell Carcinoma
Table 4
Effect of RXRA SNPs on dietary intake frequency of calcium rich foods and risk of renal cell carcinoma.
rs3118538 (IVS4-542C A)
rs10776909 (IVS1-4732C T)
Wild type
1 variant
Wild type
1 variant
Cases/Controls
Cases/Controls
Cases/Controls
Cases/Controls
N/N
OR
(UCI-LCI)
N/N
OR
(UCI-LCI)
LRT
N/N
OR
(UCI-LCI)
N/N
OR
(UCI-LCI)
LRT
Dietary Intake of Yogurt
Low (33%)
133/266
1.00
77/91
1.00
123/247
1.00
87/110
1.00
Medium (33–66%)
185/212
1.88
(1.34–2.64)
85/91
1.23
(0.73–2.08)
169/198
1.84
(1.29–2.63)
101/105
1.29
(0.81–2.07)
High (66%)
199/247
1.69
(1.18–2.42)
97/128
0.87
(0.51–1.50)
182/218
1.71
(1.18–2.49)
114/157
0.94
(0.58–1.54)
P-trend
.01
.41
.01
.58
.09
.04
Dietary Intake of Calcium Rich Foods
Low (33%)
146/248
1.00
80/97
1.00
135/236
1.00
91/109
1.00
Medium (33–66%)
180/261
1.18
(0.88–1.59)
94/94
1.22
(0.78–1.89)
162/238
1.21
(0.89–1.66)
112/117
1.10
(0.73–1.64)
High (66%)
191/216
1.39
(1.00–1.93)
85/119
0.76
(0.47–1.22)
177/189
1.49
(1.06–2.11)
99/146
0.73
(0.47–1.14)
P-trend
.05
.25
.02
.16
.03
.02
Dietary effect adjusted for age, sex, study center, BMI, self-reported hypertensive status, and smoking status. Frequency of dietary intake variables categorized into tertiles based on intake among genotyped controls. Calcium rich foods based on consumption of cheese, yogurt, and milk. Main effects adjusted for age, sex, study center, and smoking status. rs3118538 (IVS4-542C > A) main effects: AC (0.68(0.39–1.18)), AA (0.58(0.34–0.99)), P-trend = .02; AC/AA (0.82(0.67–1.00)). rs10776909 (IVS1-4732C > T) main effects: CT (0.69(0.42–1.13)), TT (0.62(0.38–1.00)), P-trend = .05; CT/TT (0.86(0.70–1.04)). Likelihood Ratio Test.
