Alterations in Lipids and Adipocyte Hormones in Female-to-Male Transsexuals

Table 2

Biochemical changes in response to 12 months of testosterone therapy in female-to-male transsexuals, including changes in lipid profile and markers of insulin resistance. Mean ± SEM, 𝑁=12 unless specified.

	Prior to Testosterone	12 months	𝑃-value
Body Mass Index (BMI) (kg/m^2)	27.5±5.2	27.6±3.9	.47
Mean Arterial Pressure (MAP (mm Hg)	87±14	91±16	.16
Serum Glutamic Oxaloacetic Transaminase (SGOT) (IU/L)	21±5	25±7	.22
Serum Glutamate Pyruvate Transaminase (SGPT) (IU/L)	19±7	24±10	.22
Serum Total Testosterone (nmol/L)	3.4±3.0	34.6±8.5	<.001
Hematocrit (%)	40±2	45±5	<.001
Platelets (×1000/𝜇L)	282±44	266±38	.21
High Density Lipoprotein (HDL) (mg/dL)	52±11	40±7	<.001
Low Density Lipoprotein (LDL) (mg/dL)	113±22	121±29	.32
Total Cholesterol (mg/dL)	184±26	181±34	.77
Triglycerides (mg/dL)	92±72	94±41	.91
Leptin (ng/dL)	31.2±29.5	19.1±17.5	.18
Resistin (ng/dL)	10.3±2.1	9.6±2.2	.68
Fasting glucose (mg/dL)	86±12	83±11	.43