Association between Serum Uric Acid Levels and Diabetes Mellitus

Table 4

Association between serum uric acid level and diabetes mellitus by hypertension.

Serum uric acid level*	Number at risk (Diabetes cases)	Multivariable-adjusted odds ratio (95% confidence interval)^†
No hypertension
Quartile 1 (<4.30 mg/dL)	2623 (150)	1 (referent)
Quartile 2 (4.30–5.20 mg/dL)	2651 (89)	0.45 (0.25–0.80)
Quartile 3 (5.30–6.20 mg/dL)	2271 (54)	0.29 (0.16–0.54)
Quartile 4 (>6.20 mg/dL)	1721 (77)	0.40 (0.22–0.70)
P trend		0.0015
Hypertension
Quartile 1 (<4.30 mg/dL)	859 (155)	1 (referent)
Quartile 2 (4.30–5.20 mg/dL)	973 (117)	0.66 (0.43–1.01)
Quartile 3 (5.30–6.20 mg/dL)	1228 (131)	0.52 (0.35–0.76)
Quartile 4 (>6.20 mg/dL)	1818 (248)	0.57 (0.38–0.86)
P trend		0.0232

*Serum uric acid quartiles: <4.3 mg/dL, 4.30–5.20 mg/dL, 5.30–6.20 mg/dL, >6.20 mg/dL.
^†Adjusted for age (years), sex (men, women), race-ethnicity (non-Hispanic whites, non-Hispanic blacks, Mexican Americans, etc.), education categories (<high school, high school, >high school), smoking (never, former, current), alcohol intake (never, former, current), BMI (normal, overweight, obese), and serum total cholesterol (mg/dL).