About this Journal Submit a Manuscript Table of Contents
International Journal of Endocrinology
Volume 2012 (2012), Article ID 156854, 4 pages
http://dx.doi.org/10.1155/2012/156854
Clinical Study

Procoagulant and Anticoagulant Factors in Childhood Hypothyroidism

1Department of Pediatrics, Ankara Training and Research Hospital, The Ministry of Health of Turkey, Ulucanlar Caddesi, Altindag, 06340 Ankara, Turkey
2Department of Pediatric Endocrinology, Ankara Training and Research Hospital, The Ministry of Health of Turkey, Ulucanlar Caddesi, Altindag, 06340 Ankara, Turkey
3Department of Pediatric Hematology, Ankara Training and Research Hospital, The Ministry of Health of Turkey, Ulucanlar Caddesi, Altindag, 06340 Ankara, Turkey

Received 23 March 2012; Revised 3 May 2012; Accepted 3 May 2012

Academic Editor: Mario Maggi

Copyright © 2012 Nevin Kilic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to investigate the effects of thyroid hormone deficiencies in childhood on the elements of coagulation proteins. Consecutive 54 children with hypothyroidism and 55 healthy controls aged 1 month–16 years were enrolled. One year after Na-L-thyroxine treatment, the study parameters were reevaluated. Thyroid function tests, procoagulant and anticoagulant proteins were performed for children with hypothyroidism and healthy controls. Significant decreased results were found in children with hypothyroidism in terms of fibrinogen, TT, and anticoagulant proteins including AT, PC, PS, and fPS. Significant increases were found with respect to APTT, fibrinogen, and TT. In the evaluation of posttreatment changes a statistically significant increase was found in vWF, FVIII, AT, PC, PS, and fPS. A positive correlation was found between fT4 and vWF, FVIII, PC, and PS. We would like to emphasize that the coagulation system especially vWF and FVIII, and particularly the anticoagulant system, should be monitored closely in patients followed up for hypothyroidism. Thyroid hormones should be examined and, if necessary, hormone replacement therapy should be administered in patients followed up for a predisposition to coagulation. Additionally, further studies with larger series are needed to investigate the effects of hypothyroidism on the coagulation system.