Association of MICA Alleles with Autoimmune Thyroid Disease in Korean Children
Table 1
MICA allele frequencies in patients with AITD and controls.
MICA allele
Controls ()
HD ()
GD ()
AITD (HD + GD) ()
MICA*002
17 (12.1%)
7 (9.7%)
8 (8.9%)
15 (9.3%)
MICA*004
10 (7.1%)
1 (1.4%)
1 (1.1%)
2 (1.2%)
MICA*006
0 (0%)
0 (0%)
1 (1.1%)
1 (0.6%)
MICA*007
5 (3.6%)
3 (4.2%)
1 (1.1%)
4 (2.5%)
MICA*008
29 (20.7%)
8 (11.1%)
8 (8.9%)
16 (9.9%)
MICA*009
7 (5.0%)
4 (5.6%)
4 (4.4%)
8 (4.9%)
MICA*010
27 (19.3%)
23 (31.9%)
33 (36.7%)
56 (34.6%)a
MICA*011
4 (2.9%)
0 (0%)
0 (0%)
0 (0%)
MICA*012
14 (10.0%)
8 (11.1%)
11 (12.2%)
19 (11.7%)
MICA*017
1 (0.7%)
0 (0%)
0 (0%)
0 (0%)
MICA*019
1 (0.7%)
2 (2.8%)
3 (3.3%)
5 (3.1%)
MICA*027
14 (10.0%)
7 (9.7%)
13 (14.4%)
20 (12.3%)
MICA*045
1 (0.7%)
3 (4.2%)
0 (0%)
3 (1.9%)
MICA*049
10 (7.1%)
6 (8.3%)
7 (7.8%)
13 (8%)
MICA: major histocompatibility complex (MHC) class I chain-related gene A; AITD: autoimmune thyroid diseases; HD: Hashimoto’s disease; GD: Graves’ disease; C: healthy control subjects; allele frequencies of MICA were in the Hardy-Weinberg equilibrium (P < 0.349); aP < 0.003 ( < 0.042), OR = 2.21 (95% confidence interval (CI), 1.30–3.76) versus C.
