Association of MICA Alleles with Autoimmune Thyroid Disease in Korean Children
Table 2
Allele frequencies of MICA in patients with GD with and without TAO.
MICA allele
Controls ()
Non-TAO ()
TAO ()
GD ()
MICA*002
17 (12.3%)
2 (4.2%)
6 (14.3%)
8 (9.8%)
MICA*004
10 (7.1%)
1 (2.1%)
0 (0%)
1 (1.2%)
MICA*006
0 (0%)
1 (2.1%)
0 (0%)
1 (1.2%)
MICA*007
5 (3.6%)
0 (0%)
1 (2.4%)
1 (1.2%)
MICA*008
29 (20.7%)
1 (2.1%)a
7 (16.7%)
8 (8.9%)
MICA*009
7 (5.0%)
3 (6.3%)
1 (2.4%)
4 (4.4%)
MICA*010
27 (19.3%)
20 (41.7%)b
13 (31.0%)
33 (36.7%)
MICA*011
4 (2.9%)
0 (0%)
0 (0%)
0 (0%)
MICA*012
14 (10.0%)
8 (16.7%)
3 (7.1%)
11 (12.2%)
MICA*017
1 (0.7%)
0 (0%)
0 (0%)
0 (0%)
MICA*019
1 (0.7%)
2 (4.2%)
1 (2.4%)
3 (3.3%)
MICA*027
14 (10.0%)
6 (12.5%)
7 (16.7%)
13 (14.4%)
MICA*045
1 (0.7%)
0 (0%)
0 (0%)
0 (0%)
MICA*049
10 (7.1%)
4 (8.3%)
3 (7.1%)
7 (7.8%)
MICA: major histocompatibility complex (MHC) class I chain-related gene A; TAO: with thyroid associated ophthalmopathy; non-TAO: without thyroid associated ophthalmopathy; GD: Graves’ disease; C: healthy control subjects; allele frequencies of MICA were in the Hardy-Weinberg equilibrium (P < 0.349); aP < 0.001 ( < 0.014), OR = 0.08 (95% CI, 0.01–0.62) versus C; bP < 0.003 ( < 0.042), OR = 2.99 (95% CI, 1.47–6.09) versus C.
