Clinical Study
Association of MICA Alleles with Autoimmune Thyroid Disease in Korean Children
Table 4
Relative strength of the disease associations of MICA*010 and HLA-B*46 with AITD.
| (a) Basic data for MICA*010 and B*46 |
| | Factor A | Factor B | Number | Control () | | MICA*010 | HLA-B*46 | AITD () |
| | + | + | 22 | 7 | | + | − | 34 | 20 | | − | + | 16 | 2 | | − | − | 90 | 111 |
| | | | 162 | 140 |
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| (b) Two-by-two comparisons |
| | Comparison | | | | | OR | P () | No. | Conclusion |
| | A versus non-A | 56 | 106 | 27 | 113 | 2.211 | 0.003 (0.02) | | MICA*010 associated | | B versus non-B | 38 | 124 | 9 | 131 | 4.461 | 0.00005 (0.0003) | | B*46 associated | | ++ versus −+ | 22 | 16 | 7 | 2 | 0.393 | 0.449 (2.694) | | MICA*010 not associated in B*46 (+) | | +− versus −− | 34 | 90 | 20 | 111 | 2.097 | 0.021 (0.126) | | MICA*010 associated in B*46 (−) | | ++ versus +− | 22 | 34 | 7 | 20 | 1.849 | 0.326 (1.956) | | B*46 not associated in MICA*010 (+) | | −+ versus −− | 16 | 90 | 2 | 111 | 9.867 | 0.0003 (0.002) | | B*46 associated in MICA*010 (−) | | +− versus −+ | 34 | 16 | 20 | 2 | 4.706 | 0.043 (0.258) | | MICA*010 and B*46 associations differ | | ++ versus −− | 22 | 90 | 7 | 111 | 3.876 | 0.002 (0.02) | | Combined MICA*010 and B*46 association |
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MICA: major histocompatibility complex (MHC) class I chain-related gene A; HLA: human leukocyte antigen; AITD: autoimmune thyroid diseases.
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