Table 4: Relative strength of the disease associations of MICA*010 and HLA-B*46 with AITD.
(a) Basic data for MICA*010 and B*46

Factor AFactor BNumberControl ( )
MICA*010HLA-B*46AITD ( )

++227
+3420
+162
90111

162140

(b) Two-by-two comparisons

Comparison ORP ( )No.Conclusion

A versus non-A56106271132.2110.003 (0.02) MICA*010 associated
B versus non-B3812491314.4610.00005 (0.0003) B*46 associated
++ versus −+2216720.3930.449 (2.694) MICA*010 not associated in B*46 (+)
+− versus − 3490201112.0970.021 (0.126) MICA*010 associated in B*46 (−)
++ versus +−22347201.8490.326 (1.956) B*46 not associated in MICA*010 (+)
−+ versus − 169021119.8670.0003 (0.002) B*46 associated in MICA*010 (−)
+− versus −+34162024.7060.043 (0.258) MICA*010 and B*46 associations differ
++ versus − 229071113.8760.002 (0.02) Combined MICA*010 and B*46 association

MICA: major histocompatibility complex (MHC) class I chain-related gene A; HLA: human leukocyte antigen; AITD: autoimmune thyroid diseases.