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International Journal of Endocrinology
Volume 2012 (2012), Article ID 379097, 5 pages
http://dx.doi.org/10.1155/2012/379097
Clinical Study

Gender-Specific Variation in the Prognosis of Papillary Thyroid Cancer TNM Stages II to IV

1Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Linkou 333, Taiwan
2Department of Pathology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Linkou 333, Taiwan
3Department of General Surgery, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Linkou 333, Taiwan

Received 30 August 2012; Accepted 5 November 2012

Academic Editor: Eleonore Fröhlich

Copyright © 2012 Sheng-Hwu Hsieh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To investigate the correlation between gender and the clinical presentation of papillary thyroid cancer and the long-term followup results, 435 patients who underwent total or near-total thyroidectomy were enrolled in this study. Among these papillary thyroid cancer patients, 12.2% showed lymph node metastases and a higher incidence of male patients in the N1b group. There were 65 from 316 female (20.6%) and 49 from 120 male (40.8%) patients who had a postoperative disease progression. A total of 55 (12.6%) patients died of thyroid cancer. Male patients showed a higher thyroid cancer mortality than the females. Multiple regression analysis showed that male gender was an independent risk factor for cancer recurrence and mortality. Male patients with TNM stages II to IV of papillary thyroid cancer need to adopt aggressive surgical and postoperative 131I therapy.