Gender-Specific Variation in the Prognosis of Papillary Thyroid Cancer TNM Stages II to IV

Table 1

Clinical features of papillary thyroid carcinoma by gender.

	Female (𝑛=315)	Male (𝑛=120)	Total (𝑛=435)	𝑃 value
Age	56.6±8.9	57.9±9.1	57.0±9.0	0.1934
TNM stage (II/III/IV)	90/60/165	27/27/66	117/87/231
T1*	128 (31.0%)	26 (19.0%)	154 (28.0%)
T2	102 (24.7%)	35 (25.5%)	137 (24.9%)	0.4023
T3	39 (9.4%)	20 (14.6%)	59 (10.7%)
T4	144 (34.9%)	56 (40.9%)	200 (36.4)
Tumor size (cm)	3.0±0.1	3.7±0.2	3.2±0.1	0.0001
LN metastases	38 (12.1%)	15 (12.5%)	53 (12.2%)
N1a	13 (41.9%)	3 (21.4%)	16 (35.6%)	0.1834
N1b	18 (58.1%)	11 (78.6%)	29 (64.4%)
Soft-tissue invasion	154 (48.9%)	51 (42.5%)	205 (47.1%)	0.2328
Distant metastases	14 (4.4%)	13 (10.8%)	27 (6.2%)	0.0136
Multicentric	92 (29.2%)	30 (25.0%)	122 (28.0%)	0.3827
Aggressive histological patterns^#	8 (2.5%)	7 (5.8%)	15 (3.4%)	0.1366
^131I dose accumulative dose (mCi)	152±10.7	227±27.9	173±11.0	0.0023
Postoperative one month ^131I uptake (%)	6.2±0.8	4.9±0.7	5.9±0.6	0.3018
Postoperative progression	65 (20.6%)	49 (40.8%)	114 (26.2%)	0.0001
Relapse/Residual	33/32	21/28	54/60	0.4023
Period of relapse from diagnosis (year)	4.4±0.7	4.1±0.6	4.3±0.4	0.7132
Disease free	94 (29.8%)	27 (22.5%)	121 (27.8%)	0.1267
Followup period (yr)	7.3±0.3	6.8±0.5	7.2±0.3	0.3501
Cancer mortality	26 (8.3%)	29 (24.2%)	55 (12.6%)	0.0001

T1*: all the patients with local invasion or distant metastases.
Aggressive histological patterns^#: tall cell, insular pattern, column cell, and poorly differentiated thyroid cancers.