Research Article

A Cell Model for Conditional Profiling of Androgen-Receptor-Interacting Proteins

Table 3

Top half: gene lists representing the BIOCARTA pathways “telomeres, telomerase, cellular aging, and immortality”, “chromatin remodeling by hSWI/SNF ATP-dependent complexes” and “control of gene expression by vitamin D receptor” found to be overrepresented among the known AR-interacting proteins identified in the N-TAP purifications by the bioinformatics tool DAVID. Bottom half: gene lists representing the “Kegg pathway”  “pathways in cancer”, and “prostate cancer” identified as being overrepresented among the known AR-interacting proteins identified in the N-TAP purifications by the bioinformatics tool “DAVID” and “g-profiler”. Listed are the interacting proteins that were unique for the proliferating cells (33), interacting proteins that were unique for the nonproliferating cells (37), and interacting proteins common to both (common). The AR is bolded.

Cellular aging, telomeres,Chromatin remodelling by SWI/SNFControl of gene expression by
immortality (DAVID)ATP-dependent complexes (DAVID)vitamin D receptor (DAVID)
33Common3733Common3733Common37

EP300
NR3C1MED1
ARID1AARID1A
HSP90ARID1B
SMARCD1SMARCD1
RB1SMARCC1SMARCC1
XRCC5SMARCA4SMARCA4
XRCC6ACTBNCOA2
TRP53NF1

pathways in cancerpathways in cancerprostate cancerprostate cancer
DAVID(g-profiler)(DAVID)(g-profiler)
33common3733common3733common3733common37

EP300EP300EP300
ARARARAR
CTNNB1CTNNB1CTNNB1CTNNB1
DAPK3DAPK3
HSP90HSP90HSP90HSP90
PIAS1PIAS1
RB1RB1
STAT3STAT3
HDAC1HDAC1
TRP53TRP53TRP53TRP53