Change of Body Composition and Adipokines and Their Relationship with Insulin Resistance across Pubertal Development in Obese and Nonobese Chinese Children: The BCAMS Study

Table 3

Stepwise forward multiple regression analyses for Ln HOMA-IR with subjects stratified by sex and pubertal development.

	Parameters	𝛽±SE	Beta	𝑃
Boys (𝑛=1616)
	Leptin*	0.135±0.029	0.253	<0.001
Prepuberty	Waist circumference	0.013±0.003	0.207	<0.001
(𝑛=704, 𝑅^2=0.377)	TG*	0.203±0.058	0.122	<0.001
	SBP	0.010±0.002	0.164	<0.001
Earlypuberty; (𝑛=258, 𝑅^2=0.464)	Leptin*	0.226±0.004	0.407	<0.001
	Waist circumference	0.014±0.004	0.237	0.001
	TG*	0.229±0.082	0.143	0.006
Midpuberty; (𝑛=594, 𝑅^2=0.442)	Leptin*	0.237±0.019	0.515	<0.001
	TG*	0.299±0.052	0.200	<0.001
	Adiponectin*	−0.123±0.038	−0.103	0.001
Late-puberty; (𝑛=60, 𝑅^2=0.325)	Leptin*	0.137±0.064	0.252	0.038
	TG*	0.650±0.182	0.422	0.001
Girls (𝑛=1607)
	Leptin*	0.124±0.037	0.234	0.001
Pre-puberty	Waist circumference	0.029±0.006	0.365	<0.001
(𝑛=299, 𝑅^2=0.483)	TG*	0.243±0.077	0.146	0.002
	SBP	0.006±0.003	0.107	0.022
	Leptin*	0.153±0.049	0.263	0.002
Earlypuberty	Waist circumference	0.019±0.007	0.235	0.006
(𝑛=206, 𝑅^2=0.396)	TG*	0.267±0.100	0.163	0.008
	SBP	0.010±0.003	0.175	0.003
	Leptin*	0.263±0.029	0.389	<0.001
Mid-puberty	Waist circumference	0.017±0.004	0.254	<0.001
(𝑛=789, 𝑅^2=0.330)	TG*	0.244±0.069	0.169	<0.001
	SBP	0.006±0.003	0.018	0.032
	Leptin*	0.204±0.043	0.271	<0.001
Latepuberty	Waist circumference	0.017±0.004	0.254	<0.001
(𝑛=313,𝑅^2=0.340)	TG*	0.244±0.069	0.169	<0.001
	SBP	0.006±0.003	0.108	0.032

Independent parameters: leptin, diponectin, TG, SBP, DBP, HDL-C, waist circumference, or BMI z-score or FAT%. *Skewed distributions were logarithmically transformed for analysis. Abbreviations as Table 1.