About this Journal Submit a Manuscript Table of Contents
International Journal of Endocrinology
Volume 2012 (2012), Article ID 414812, 7 pages
http://dx.doi.org/10.1155/2012/414812
Review Article

Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy

1Department of Surgery, University of British Columbia, 3100, 910 West 10th Avenue, Vancouver, BC, Canada V5Z 4E3
2Department of Pediatrics, University of British Columbia, 3100, 910 West 10th Avenue, Vancouver, BC, Canada V5Z 4E3

Received 2 November 2011; Accepted 24 February 2012

Academic Editor: Bashoo Naziruddin

Copyright © 2012 Xiaojie Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Islet cell transplantation offers a potential cure for type 1 diabetes, but it is challenged by insufficient donor tissue and side effects of current immunosuppressive drugs. Therefore, alternative sources of insulin-producing cells and isletfriendly immunosuppression are required to increase the efficiency and safety of this procedure. Beta cells can be transdifferentiated from precursors or another heterologous (non-beta-cell) source. Recent advances in beta cell regeneration from somatic cells such as fibroblasts could circumvent the usage of immunosuppressive drugs. Therefore, generation of patient-specific beta cells provides the potential of an evolutionary treatment for patients with diabetes.