Table 1: The effects of dihydropyridine CCBs on dbcAMP- or KCl-induced expression of steroidogenic enzymes.

Dihydropyridine CCB Type of affecting Ca2+ channels StAR CYP11A1 3βHSD2 CYP21A2 CYP11B1 CYP11B2 STS SULT2A1 Amlodipine L, T → → → →     → → Azelnidipine L, T → → → → ↓ ↓ → → Benidipine L, T         ↓ ↓     Efonidipine L, T ↑ → → → ↓ ↓ → → Isradipine L, T ↑               Nifedipine L ↑ → → → ↓ ↓ → → Nitrendipine L         ↓ ↓

dbcAMP: N6, 2′-O-dibutyryladenosine 3′, and 5′-cyclic monophosphate.