Research Article
Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions
Figure 6
db/db mice respond to running with a distinct transcriptional profile. (a) Leptin receptor-deficient db/db mice exhibit transcriptional upregulation, indicated by positive Z-ratios, following twelve weeks of voluntary wheel running. Rpe, ribulose-5-phosphate-3-epimerase; Glra1, glycine receptor, alpha 1 subunit; Snx1, sorting nexin 1; Naga, N-acetyl galactosaminidase, alpha; Hace1, HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1; Heatr5a, HEAT repeat containing 5A. (b) Pathway analysis of genes regulated by voluntary exercise in db/db mice. Abbreviations: Il6st, interleukin 6 signal transducer; Tbr1, T-box brain gene 1; Nrg1, neuregulin 1; Abcd2, ATP-binding cassette, sub-family D, member 2. (c) PCR validation of differences in gene expression following running in db/db mice.
