Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions

Figure 8

db/db and C57Bl/6 mice respond differently to exercise and caloric restriction. (a) Heat map profiles showing that db/db and C57Bl/6 mice exhibit distinct transcriptional responses to energetic challenges. (b) Venn diagram showing the number of genes expressed following voluntary wheel running in C57Bl/6 and db/db mice. (c) Venn diagram showing the number of transcripts responsive to CR in C57Bl/6 and db/db mice. (d) Side-by-side comparison of the number of genes that differ between C57Bl/6 and db/db mice following running or CR.