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International Journal of Endocrinology
Volume 2012 (2012), Article ID 785247, 6 pages
The Effect of Captopril on Impaired Wound Healing in Experimental Diabetes
1Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
2Isfahan Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3Department of Physiology, Isfahan Payame Noor University, Isfahan, Iran
Received 30 January 2012; Revised 25 April 2012; Accepted 25 May 2012
Academic Editor: Leon Bach
Copyright © 2012 Ehsan Zandifar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- D. G. Greenhalgh, “Wound healing and diabetes mellitus,” Clinics in Plastic Surgery, vol. 30, no. 1, pp. 37–45, 2003.
- F. Cosentino and T. F. Lüscher, “Endothelial dysfunction in diabetes mellitus,” Journal of Cardiovascular Pharmacology, vol. 32, no. 3, pp. S54–S61, 1998.
- R. Blakytny and E. Jude, “The molecular biology of chronic wounds and delayed healing in diabetes,” Diabetic Medicine, vol. 23, no. 6, pp. 594–608, 2006.
- R. Lobmann, A. Ambrosch, G. Schultz, K. Waldmann, S. Schiweck, and H. Lehnert, “Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients,” Diabetologia, vol. 45, no. 7, pp. 1011–1016, 2002.
- M. R. Schäffer, U. Tantry, P. A. Efron, G. M. Ahrendt, F. J. Thornton, and A. Barbul, “Diabetes-impaired healing and reduced wound nitric oxide synthesis: a possible pathophysiologic correlation,” Surgery, vol. 121, no. 5, pp. 513–519, 1997.
- M. Kalani, J. Ostergren, K. Brismar, G. Jörneskog, and B. Fagrell, “Transcutaneous oxygen tension and toe blood pressure as predictors for outcome of diabetic foot ulcers,” Diabetes Care, vol. 22, no. 1, pp. 147–151, 1999.
- A. Martin, M. R. Komada, and D. C. Sane, “Abnormal angiogenesis in diabetes mellitus,” Medicinal Research Reviews, vol. 23, no. 2, pp. 117–145, 2003.
- C. C. Chua, R. C. Hamdy, and B. H. L. Chua, “Upregulation of vascular endothelial growth factor by angiotensin II in rat heart endothelial cells,” Biochimica et Biophysica Acta, vol. 1401, no. 2, pp. 187–194, 1998.
- R. Tamarat, J. S. Silvestre, M. Duriez, and B. I. Levy, “Angiotensin II angiogenic effect in vivo involves vascular endothelial growth factor- and inflammation-related pathways,” Laboratory Investigation, vol. 82, no. 6, pp. 747–756, 2002.
- Office of Laboratory Animal Welfare, Office of Extramural Research, National Institutes of Health, Public Health Service Policy on Human Care and Use of Laboratory Animals, 2002, http://grants1.nih.gov/grants/olaw/references/phspol.htm.
- D. Yavuz, B. Küçükkaya, G. Haklar, O. Ersöz, E. Akoğlu, and S. Akalin, “Effects of captopril and losartan on lipid peroxidation, protein oxidation and nitric oxide release in diabetic rat kidney,” Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 69, no. 4, pp. 223–227, 2003.
- J. Duarte, A. Martinez, A. Bermejo et al., “Cardiovascular effects of captopril and enalapril in obese Zucker rats,” European Journal of Pharmacology, vol. 365, no. 2-3, pp. 225–232, 1999.
- C. D. Barro, J. P. Romanet, A. Fdili, M. Guillot, and F. Morel, “Gelatinase concentration in tears of corneal-grafted patients,” Current Eye Research, vol. 17, no. 2, pp. 174–182, 1998.
- M. Muller, C. Trocme, B. Lardy, F. Morel, S. Halimi, and P. Y. Benhamou, “Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing,” Diabetic Medicine, vol. 25, no. 4, pp. 419–426, 2008.
- J. V. Boykin and C. Baylis, “Hyperbaric oxygen therapy mediates increased nitric oxide production associated with wound healing: a preliminary study,” Advances in Skin & Wound Care, vol. 20, no. 7, pp. 382–388, 2007.
- S. Haghjooyjavanmard, M. Nematbakhsh, A. Monajemi, and M. Soleimani, “von Willebrand factor, C-reactive protein, nitric oxide, and vascular endothelial growth factor in a dietary reversal model of hypercholesterolemia in rabbit,” Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia, vol. 152, no. 1, pp. 91–95, 2008.
- K. Maruyama, J. Asai, M. Ii, T. Thorne, D. W. Losordo, and P. A. D'Amore, “Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing,” American Journal of Pathology, vol. 170, no. 4, pp. 1178–1191, 2007.
- S. H. Javanmard, M. Nematbakhsh, and A. Monajemi, “L-Arginine supplementation influenced nitrite but not nitrate and total nitrite in rabbit model of hypercholesterolemia,” Iranian Biomedical Journal, vol. 12, no. 3, pp. 179–184, 2008.
- R. A. F. Clark, “Cutaneous tissue repair: basic biologic considerations. I,” Journal of the American Academy of Dermatology, vol. 13, no. 5, pp. 701–725, 1985.
- M. B. Witte, F. J. Thornton, U. Tantry, and A. Barbul, “L-arginine supplementation enhances diabetic wound healing: involvement of the nitric oxide synthase and arginase pathways,” Metabolism, vol. 51, no. 10, pp. 1269–1273, 2002.
- H. Kämpfer, J. Pfeilschifter, and S. Frank, “Expression and activity of arginase isoenzymes during normal anddiabetes-impaired skin repair,” Journal of Investigative Dermatology, vol. 121, no. 6, pp. 1544–1551, 2003.
- M. R. Kichuk, X. Zhang, M. Oz et al., “Angiotensin-converting enzyme inhibitors promote nitric oxide production in coronary microvessels from failing explanted human hearts,” American Journal of Cardiology, vol. 80, no. 3, pp. 137A–142A, 1997.
- G. O'Driscoll, D. Green, J. Rankin, K. Stanton, and R. Taylor, “Improvement in endothelial function by angiotensin converting enzyme inhibition in insulin-dependent diabetes mellitus,” The Journal of Clinical Investigation, vol. 100, no. 3, pp. 678–684, 1997.
- C. Cheetham, J. Collis, G. O'Driscoll, K. Stanton, R. Taylor, and D. Green, “Losartan, an angiotensin type 1 receptor antagonist, improves endothelial function in non-insulin-dependent diabetes,” Journal of the American College of Cardiology, vol. 36, no. 5, pp. 1461–1466, 2000.
- M. Takemoto, K. Egashira, M. Usui et al., “Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats,” The Journal of Clinical Investigation, vol. 99, no. 2, pp. 278–287, 1997.
- L. Ghiadoni, D. Versari, A. Magagna et al., “Ramipril dose-dependently increases nitric oxide availability in the radial artery of essential hypertension patients,” Journal of Hypertension, vol. 25, no. 2, pp. 361–366, 2007.
- V. Tchaikovski, S. Olieslagers, F. D. Böhmer, and J. Waltenberger, “Diabetes mellitus activates signal transduction pathways resulting in vascular endothelial growth factor resistance of human monocytes,” Circulation, vol. 120, no. 2, pp. 150–159, 2009.
- J. S. Silvestre, S. Bergaya, R. Tamarat, M. Duriez, C. M. Boulanger, and B. I. Levy, “Proangiogenic effect of angiotensin-converting enzyme inhibition is mediated by the bradykinin B2 receptor pathway,” Circulation Research, vol. 89, no. 8, pp. 678–683, 2001.
- P. Li, T. Kondo, Y. Numaguchi et al., “Role of bradykinin, nitric oxide, and angiotensin II type 2 receptor in imidapril-induced angiogenesis,” Hypertension, vol. 51, no. 2, pp. 252–258, 2008.
- P. Gohlke, I. Kuwer, A. Schnell, K. Amann, G. Mall, and T. Unger, “Blockade of bradykinin B2 receptors prevents the increase in capillary density induced by chronic angiotensin-converting enzyme inhibitor treatment in stroke-prone spontaneously hypertensive rats,” Hypertension, vol. 29, no. 1, pp. 478–482, 1997.
- L. Gao and D. M. Yu, “Molecular mechanism of limbs' postischemic revascularization improved by perindopril in diabetic rats,” Chinese Medical Journal, vol. 121, no. 21, pp. 2129–2133, 2008.
- J. Dulak and A. Józkowicz, “Regulation of vascular endothelial growth factor synthesis by nitric oxide: facts and controversies,” Antioxidants and Redox Signaling, vol. 5, no. 1, pp. 123–132, 2003.
- M. I. Lin and W. C. Sessa, “Vascular endothelial growth factor signaling to endothelial nitric oxide synthase: more than a FLeeTing moment,” Circulation Research, vol. 99, no. 7, pp. 666–668, 2006.
- D. A. Walsh, D. E. Hu, J. Wharton, J. D. Catravas, D. R. Blake, and T. P. D. Fan, “Sequential development of angiotensin receptors and angiotensin I converting enzyme during angiogenesis in the rat subcutaneous sponge granuloma,” British Journal of Pharmacology, vol. 120, no. 7, pp. 1302–1311, 1997.
- R. Tamarat, J. S. Silvestre, N. Kubis et al., “Endothelial nitric oxide synthase lies downstream from angiotensin II-induced angiogenesis in ischemic hindlimb,” Hypertension, vol. 39, no. 3, pp. 830–835, 2002.
- J. S. Silvestre, N. Kamsu-Kom, M. Clergue, M. Duriez, and B. I. Lévy, “Very-low-dose combination of the angiotensin-converting enzyme inhibitor perindopril and the diuretic indapamide induces an early and sustained increase in neovascularization in rat ischemic legs,” Journal of Pharmacology and Experimental Therapeutics, vol. 303, no. 3, pp. 1038–1043, 2002.