About this Journal Submit a Manuscript Table of Contents
International Journal of Endocrinology
Volume 2012 (2012), Article ID 856359, 7 pages
http://dx.doi.org/10.1155/2012/856359
Clinical Study

Association of Lipids with Oxidative Stress Biomarkers in Subclinical Hypothyroidism

Programa de Pós-Graduação em Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil

Received 5 July 2012; Accepted 17 October 2012

Academic Editor: Leon Bach

Copyright © 2012 Adriana Santi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Razvi, A. Shakoor, M. Vanderpump, J. U. Weaver, and S. H. S. Pearce, “The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease: a metaanalysis,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 8, pp. 2998–3007, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. W. J. Hueston and W. S. Pearson, “Subclinical hypothyroidism and the risk of hypercholesterolemia,” Annals of Family Medicine, vol. 2, no. 4, pp. 351–355, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Donnini, F. S. Ambesi-Impiombato, and F. Curcio, “Thyrotropin stimulates production of procoagulant and vasodilatative factors in human aortic endothelial cells,” Thyroid, vol. 13, no. 6, pp. 517–521, 2003. View at Scopus
  4. A. Becerra, D. Bellido, A. Luengo, G. Piédrola, and D. A. De Luis, “Lipoprotein(a) and other lipoproteins in hypothyroid patients before and after thyroid replacement therapy,” Clinical Nutrition, vol. 18, no. 5, pp. 319–322, 1999. View at Publisher · View at Google Scholar · View at Scopus
  5. S. A. Wiseman, J. T. Powell, S. E. Humphries, and M. Press, “The magnitude of the hypercholesterolemia of hypothyroidism is associated with variation in the low density lipoprotein receptor gene,” Journal of Clinical Endocrinology and Metabolism, vol. 77, no. 1, pp. 108–112, 1993. View at Publisher · View at Google Scholar · View at Scopus
  6. M. M. Mya and W. S. Aronow, “Subclinical hypothyroidism is associated with coronary artery disease in older persons,” Journals of Gerontology A, vol. 57, no. 10, pp. M658–M659, 2002. View at Scopus
  7. K. W. Geul, I. L. L. Van Sluisveld, D. E. Grobbee et al., “The importance of thyroid microsomal antibodies in the development of elevated serum TSH in middle-aged women: associations with serum lipids,” Clinical Endocrinology, vol. 39, no. 3, pp. 275–280, 1993. View at Scopus
  8. A. A. Al-Tonsi, A. A. Abdel-Gayoum, and M. Saad, “The secondary dyslipidemia and deranged serum phosphate concentration in thyroid disorders,” Experimental and Molecular Pathology, vol. 76, no. 2, pp. 182–187, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. M. J. Coria, A. I. Pastrán, and M. S. Gimenez, “Serum oxidative stress parameters of women with hypothyroidism,” Acta Biomedica de l'Ateneo Parmense, vol. 80, no. 2, pp. 135–139, 2009. View at Scopus
  10. M. Messarah, A. Boumendjel, A. Chouabia et al., “Influence of thyroid dysfunction on liver lipid peroxidation and antioxidant status in experimental rats,” Experimental and Toxicologic Pathology, vol. 62, no. 3, pp. 301–310, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Dumitriu, R. Bartoc, H. Ursu, M. Purice, and V. Ionescu, “Significance of high levels of serum malonyl dialdehyde (MDA) and ceruloplasmin (CP) in hyper- and hypothyroidism.,” Endocrinologie, vol. 26, no. 1, pp. 35–38, 1988. View at Scopus
  12. D. Konukoglu, M. Ercan, and H. Hatemi, “Plasma viscosity in female patients with hypothyroidism: effects of oxidative stress and cholesterol,” Clinical Hemorheology and Microcirculation, vol. 27, no. 2, pp. 107–113, 2002. View at Scopus
  13. A. N. Torun, S. Kulaksizoglu, M. Kulaksizoglu, B. O. Pamuk, E. Isbilen, and N. B. Tutuncu, “Serum total antioxidant status and lipid peroxidation marker malondialdehyde levels in overt and subclinical hypothyroidism,” Clinical Endocrinology, vol. 70, no. 3, pp. 469–474, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Bouderbala, M. Lamri-Senhadji, J. Prost, M. A. Lacaille-Dubois, and M. Bouchenak, “Changes in antioxidant defense status in hypercholesterolemic rats treated with Ajuga iva,” Phytomedicine, vol. 15, no. 6-7, pp. 453–461, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Nanda, Z. Bobby, and A. Hamide, “Oxidative stress and protein glycation in primary hypothyroidism. Male/female difference,” Clinical and Experimental Medicine, vol. 8, no. 2, pp. 101–108, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Kebapcilar, B. Akinci, F. Bayraktar et al., “Plasma thiobarbituric acid-reactive substance levels in subclinical hypothyroidism,” Medical Principles and Practice, vol. 16, no. 6, pp. 432–436, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. Z. Serdar, K. Aslan, M. Dirican, E. Sarandöl, D. Yeşilbursa, and A. Serdar, “Lipid and protein oxidation and antioxidant status in patients with angiographically proven coronary artery disease,” Clinical Biochemistry, vol. 39, no. 8, pp. 794–803, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Das and G. B. N. Chainy, “Thyroid Hormone influences antioxidant defense system in adult rat brain,” Neurochemical Research, vol. 29, no. 9, pp. 1755–1766, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Senthil, R. M. Veerappan, M. Ramakrishna Rao, and K. V. Pugalendi, “Oxidative stress and antioxidants in patients with cardiogenic shock complicating acute myocardial infarction,” Clinica Chimica Acta, vol. 348, no. 1-2, pp. 131–137, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. B. Mackness, P. N. Durrington, and M. I. Mackness, “The paraoxonase gene family and coronary heart disease,” Current Opinion in Lipidology, vol. 13, no. 4, pp. 357–362, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Quéméneur, F. Martin-Nizard, A. Kandoussi et al., “PON1, a new biomarker of cardiovascular disease, is low in patients with systemic vasculitis,” Seminars in Arthritis and Rheumatism, vol. 37, no. 3, pp. 149–155, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Olivero-David, A. Schultz-Moreira, M. Vázquez-Velasco et al., “Effects of Nori- and Wakame-enriched meats with or without supplementary cholesterol on arylesterase activity, lipaemia and lipoproteinaemia in growing Wistar rats,” British Journal of Nutrition, vol. 106, pp. 1476–1486, 2011.
  23. R. Luboshitzky, A. Aviv, P. Herer, and L. Lavie, “Risk factors for cardiovascular disease in women with subclinical hypothyroidism,” Thyroid, vol. 12, no. 5, pp. 421–425, 2002. View at Scopus
  24. P. S. Bachorik and J. J. Albers, “Precipitation methods for quantification of lipoproteins,” Methods in Enzymology, vol. 129, pp. 78–100, 1986. View at Scopus
  25. W. T. Friedewald, R. I. Levy, and D. S. Fredrickson, “Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge,” Clinical Chemistry, vol. 18, no. 6, pp. 499–502, 1972. View at Scopus
  26. A. M. Jentzsch, H. Bachmann, P. Fürst, and H. K. Biesalski, “Improved analysis of malondialdehyde in human body fluids,” Free Radical Biology and Medicine, vol. 20, no. 2, pp. 251–256, 1996. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Aebi, “Catalase in vitro,” Methods in Enzymology, vol. 105, pp. 121–126, 1984. View at Publisher · View at Google Scholar · View at Scopus
  28. J. M. McCord and I. Fridovich, “Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein),” Journal of Biological Chemistry, vol. 244, no. 22, pp. 6049–6055, 1969. View at Scopus
  29. J. Bełtowski, G. Wójcicka, and A. Jamroz, “Differential effect of 3-hydroxy-3-methylglutarylcoenzyme a reductase inhibitors on plasma paraoxonase 1 activity in the rat,” Polish Journal of Pharmacology, vol. 54, no. 6, pp. 661–671, 2002. View at Scopus
  30. C. Huesca-Gómez, M. Franco, G. Luc et al., “Chronic hypothyroidism induces abnormal structure of high-density lipoproteins and impaired kinetics of apolipoprotein A-I in the rat,” Metabolism, vol. 51, no. 4, pp. 443–450, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. Z. Efstathiadou, S. Bitsis, H. J. Milionis et al., “Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial?” European Journal of Endocrinology, vol. 145, no. 6, pp. 705–710, 2001. View at Scopus
  32. M. Yildirimkaya, M. Özata, K. Yilmaz, C. Kilinç, M. A. Gündoǧan, and T. Kutluay, “Lipoprotein(a) concentration in subclinical hypothyroidism before and after levo-thyroxine therapy,” Endocrine Journal, vol. 43, no. 6, pp. 731–736, 1996. View at Scopus
  33. S. Miura, M. Iitaka, H. Yoshimura et al., “Disturbed lipid metabolism in patients with subclinical hypothyroidism: effect of L-thyroxine therapy,” Internal Medicine, vol. 33, no. 7, pp. 413–417, 1994. View at Scopus
  34. S. Turhan, S. Sezer, G. Erden et al., “Plasma homocysteine concentrations and serum lipid profile as atherosclerotic risk factors in subclinical hypothyroidism,” Annals of Saudi Medicine, vol. 28, no. 2, pp. 96–101, 2008. View at Scopus
  35. L. Lu, B. Wang, Z. Shan et al., “The correlation between thyrotropin and dyslipidemia in a population-based study,” Journal of Korean Medical Science, vol. 26, no. 2, pp. 243–249, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Taddei, N. Caraccio, A. Virdis et al., “Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 8, pp. 3731–3737, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. W. Y. Lee, J. Y. Suh, E. J. Rhee, J. S. Park, K. C. Sung, and S. W. Kim, “Plasma CRP, apolipoprotein A-1, apolipoprotein B and Lp(a) levels according to thyroid function status,” Archives of Medical Research, vol. 35, no. 6, pp. 540–545, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. A. Iqbal, R. Jorde, and Y. Figenschau, “Serum lipid levels in relation to serum thyroid-stimulating hormone and the effect of thyroxine treatment on serum lipid levels in subjects with subclinical hypothyroidism: the Tromsø Study,” Journal of Internal Medicine, vol. 260, no. 1, pp. 53–61, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. P. Venditti and S. Di Meo, “Thyroid hormone-induced oxidative stress,” Cellular and Molecular Life Sciences, vol. 63, no. 4, pp. 414–434, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Messarah, M. S. Boulakoud, A. Boumendjel, C. Abdennour, and A. El Feki, “The impact of thyroid activity variations on some oxidizing-stress parameters in rats,” Comptes Rendus—Biologies, vol. 330, no. 2, pp. 107–112, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. K. Asayama and K. Kato, “Oxidative muscular injury and its relevance to hyperthyroidism,” Free Radical Biology and Medicine, vol. 8, no. 3, pp. 293–303, 1990. View at Publisher · View at Google Scholar · View at Scopus
  42. M. López-Torres, M. Romero, and G. Barja, “Effect of thyroid hormones on mitochondrial oxygen free radical production and DNA oxidative damage in the rat heart,” Molecular and Cellular Endocrinology, vol. 168, no. 1-2, pp. 127–134, 2000. View at Publisher · View at Google Scholar · View at Scopus
  43. M. M. M. F. Duarte, R. N. Moresco, T. Duarte et al., “Oxidative stress in hypercholesterolemia and its association with Ala16Val superoxide dismutase gene polymorphism,” Clinical Biochemistry, vol. 43, no. 13-14, pp. 1118–1123, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. N. Nanda, Z. Bobby, A. Hamide, B. C. Koner, and M. G. Sridhar, “Association between oxidative stress and coronary lipid risk factors in hypothyroid women is independent of body mass index,” Metabolism: Clinical and Experimental, vol. 56, no. 10, pp. 1350–1355, 2007. View at Publisher · View at Google Scholar · View at Scopus
  45. A. Santi, M. M. M. F. Duarte, R. N. Moresco et al., “Association between thyroid hormones, lipids and oxidative stress biomarkers in overt hypothyroidism,” Clinical Chemistry and Laboratory Medicine, vol. 48, no. 11, pp. 1635–1639, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. M. Aviram, M. Rosenblat, C. L. Bisgaier, R. S. Newton, S. L. Primo-Parmo, and B. N. La Du, “Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions: a possible peroxidative role for paraoxonase,” Journal of Clinical Investigation, vol. 101, no. 8, pp. 1581–1590, 1998. View at Scopus
  47. K. Sumegová, P. Blažíček, I. Waczulíková, I. Žitňanová, and Z. Ďuračková, “Activity of paraoxonase 1 (PON1) and its relationship to markers of lipoprotein oxidation in healthy Slovaks,” Acta Biochimica Polonica, vol. 53, no. 4, pp. 783–787, 2006. View at Scopus
  48. E. Cebeci, F. Alibaz-Oner, M. Usta, S. Yurdakul, and M. Erguney, “Evaluation of oxidative stress, the activities of paraoxonase and arylesterase in patients with subclinical hypothyroidism,” Journal of Investigative Medicine, vol. 60, pp. 23–28, 2012.
  49. G. Baskol, H. Atmaca, F. Tanriverdi, M. Baskol, D. Kocer, and F. Bayram, “Oxidative stress and enzymatic antioxidant status in patients with hypothyroidism before and after treatment,” Experimental and Clinical Endocrinology and Diabetes, vol. 115, no. 8, pp. 522–526, 2007. View at Publisher · View at Google Scholar · View at Scopus
  50. Y. Ikeda, M. Inoue, T. Suehiro, K. Arii, Y. Kumon, and K. Hashimoto, “Low human paraoxonase predicts cardiovascular events in Japanese patients with type 2 diabetes,” Acta Diabetologica, vol. 46, no. 3, pp. 239–242, 2009. View at Publisher · View at Google Scholar · View at Scopus
  51. D. M. Shih and A. J. Lusis, “The roles of PON1 and PON2 in cardiovascular disease and innate immunity,” Current Opinion in Lipidology, vol. 20, no. 4, pp. 288–292, 2009. View at Publisher · View at Google Scholar · View at Scopus
  52. L. H. Duntas, E. Mantzou, and D. A. Koutras, “Circulating levels of oxidized low-density lipoprotein in overt and mild hypothyroidism,” Thyroid, vol. 12, no. 11, pp. 1003–1007, 2002. View at Scopus