|
| Most common investigating causes of POI | Less common investigating causes of POI |
|
| Chromosomal abnormalities (gonadal dysgenesis with or without Turner syndrome) | Part of a multiple endocrinopathy
(i) hypoparathyroidism,
(ii) hypoadrenalism,
(iii) & mucocutaneous candidiasis |
|
Premutation of X-chromosome
(FMR1 gene)
Fragile X syndrome | Autoimmune diseases such as
(i) autoimmune lymphocytic oophoritis,
(ii) dry-eye syndrome,
(iii) myasthenia gravis,
(iv) rheumatoid arthritis,
(v) systemic lupus erythematosus |
|
| Damage from chemotherapy or radiation therapy | Viral infections
Galactosemia |
|
| Surgical oophorectomy (surgical extirpation) | Sarcoidosis |
|