925143.fig.001a
(a)
925143.fig.001b
(b)
925143.fig.001c
(c)
925143.fig.001d
(d)
925143.fig.001e
(e)
Figure 1: Chemical structures of small molecules reported to induce beta-cell proliferation. (a) 1-Azakenpaullone, a GSK-3β  inhibitor [47]. (b) GKA50, a glucokinase activator [51]. (c) PSN632408, a GPR119 agonist [52]. (d) Bay K 8644, an L-type calcium channel activator [53]. (e) 5-Iodotubercidin, an adenosine kinase inhibitor [54].