Research Article

Comparison of Insulin Lispro Protamine Suspension with NPH Insulin in Pregnant Women with Type 2 and Gestational Diabetes Mellitus: Maternal and Perinatal Outcomes

Table 1

Baseline characteristics of pregnant women receiving ILPS or NPH insulin.

ILPSgNPHg

No. 5336
Type of diabetes (T2DM/GDM)7/4618/180.0002
Caucasian ethnicity (%)90.6 (48/53)91.7 (33/36)ns
Age (yrs)
 Total34.7 5.834.2 4.8ns
 T2DM 36.0 4.333.4 5.3ns
 GDM34.5 6.034.9 4.3ns
Prepregnancy BMI (kg/m2)
 Total 28.6 5.728.8 7.2ns
 T2DM30.9 6.029.2 7.2ns
 GDM28.3 5.728.4 7.3ns
Gestational week at 1st visit
 Total22.2 8.4 14.1 8.9<0.0001
 T2DM15.4 9.69.2 6.6ns
 GDM23.3 7.819.0 8.3ns
Gestational week at enrollment
 Total27.8 8.120.3 11.10.0004
 T2DM15.4 13.211.1 7.1ns
 GDM29.1 6.329.5 4.9ns
Weight increase at enrollment (kg)
 Total7.7 6.74.4 4.40.01
 T2DM4.7 6.71.7 2.4ns
 GDM8.2 6.77.1 4.3ns
Preenrollment short-acting insulin dose (units/kg/day)
 Total0.18 0.100.27 0.160.01
 T2DM0.22 0.130.30 0.18ns
 GDM0.18 0.090.23 0.14ns

BMI: body mass index; T2DM: type 2 diabetes mellitus; GDM: gestational diabetes mellitus.