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International Journal of Endocrinology
Volume 2013 (2013), Article ID 167138, 7 pages
Osteoporosis Associated with Antipsychotic Treatment in Schizophrenia
1Institute of Mental Health, Second Xiangya Hospital, Central South University, Changsha 410011, China
2Department of Nursing, Second Xiangya Hospital, Central South University, Changsha 410011, China
Received 19 December 2012; Revised 20 February 2013; Accepted 18 March 2013
Academic Editor: Guang-Da Xiang
Copyright © 2013 Haishan Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- J. H. Renn, N. P. Yang, C. M. Chueh, C. Y. Lin, T. H. Lan, and P. Chou, “Bone mass in schizophrenia and normal populations across different decades of life,” BMC Musculoskeletal Disorders, vol. 10, article 1, 2009.
- J. Tiihonen, J. Lönnqvist, K. Wahlbeck et al., “11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study),” The Lancet, vol. 374, no. 9690, pp. 620–627, 2009.
- S. Kisely, N. Preston, J. Xiao, et al., “Reducing all-cause mortality among patients with psychiatric disorders: a population-based study,” Canadian Medical Association Journal, vol. 185, no. 1, pp. 50–56, 2013.
- D. P. J. Osborn, G. Levy, I. Nazareth, I. Petersen, A. Islam, and M. B. King, “Relative risk of cardiovascular and cancer mortality in people with severe mental illness from the United Kingdom's General Practice Research Database,” Archives of General Psychiatry, vol. 64, no. 2, pp. 242–249, 2007.
- J. Y. Reginster and N. Burlet, “Osteoporosis: a still increasing prevalence,” Bone, vol. 38, no. 2, supplement 1, pp. S4–S9, 2006.
- L. Nshimyumukiza, A. Durand, M. Gagnon et al., “An economic evaluation: simulation of the cost/effectiveness and cost/utility of universal prevention strategies against osteoporosis-related fractures,” Journal of Bone and Mineral Research, vol. 28, no. 2, pp. 383–394, 2013.
- S. R. Cummings and L. J. Melton, “Osteoporosis I: epidemiology and outcomes of osteoporotic fractures,” Lancet, vol. 359, no. 9319, pp. 1761–1767, 2002.
- T. Higuchi, T. Komoda, M. Sugishita et al., “Certain neuroleptics reduce bone mineralization in schizophrenic patients,” Neuropsychobiology, vol. 18, no. 4, pp. 185–188, 1987.
- N. J. Delva, J. L. Crammer, S. V. Jarzylo et al., “Osteopenia, pathological fractures, and increased urinary calcium excretion in schizophrenic patients with polydipsia,” Biological Psychiatry, vol. 26, no. 8, pp. 781–793, 1989.
- G. Abraham, R. H. Friedman, C. Verghese, and J. de Leon, “Osteoporosis and schizophrenia: can we limit known risk factors?” Biological Psychiatry, vol. 38, no. 2, pp. 131–132, 1995.
- G. Abraham, U. Halbreich, R. H. Friedman, and R. C. Josiassen, “Bone mineral density and prolactin associations in patients with chronic schizophrenia,” Schizophrenia Research, vol. 59, no. 1, pp. 17–18, 2003.
- S. Pouwels, T. P. Van Staa, A. C. G. Egberts, H. G. M. Leufkens, C. Cooper, and F. de Vries, “Antipsychotic use and the risk of hip/femur fracture: a population-based case-control study,” Osteoporosis International, vol. 20, no. 9, pp. 1499–1506, 2009.
- G. W. K. Hugenholtz, E. R. Heerdink, T. P. Van Staa, W. A. Nolen, and A. C. G. Egberts, “Risk of hip/femur fractures in patients using antipsychotics,” Bone, vol. 37, no. 6, pp. 864–870, 2005.
- V. O'Keane and A. M. Meaney, “Antipsychotic drugs: a new risk factor for osteoporosis in young women with schizophrenia?” Journal of Clinical Psychopharmacology, vol. 25, no. 1, pp. 26–31, 2005.
- T. Kishimoto, M. de Hert, H. E. Carlson, P. Manu, and C. U. Correll, “Osteoporosis and fracture risk in people with schizophrenia,” Current Opinion in Psychiatry, vol. 25, no. 5, pp. 415–429, 2012.
- L. Howard, G. Kirkwood, and M. Leese, “Risk of hip fracture in patients with a history of schizophrenia,” British Journal of Psychiatry, vol. 190, pp. 129–134, 2007.
- D. U. Jung, D. L. Kelly, M. K. Oh et al., “Bone mineral density and osteoporosis risk in older patients with schizophrenia,” Journal of Clinical Psychopharmacology, vol. 31, no. 4, pp. 406–410, 2011.
- P. Rey-Sanchez, J. M. Lavado-García, M. L. Canal-Macías, M. A. Gómez-Zubeldia, R. Roncero-Martín, and J. D. Pedrera-Zamorano, “Ultrasound bone mass in schizophrenic patients on antipsychotic therapy,” Human Psychopharmacology, vol. 24, no. 1, pp. 49–54, 2009.
- K. M. Abel, H. F. Heatlie, L. M. Howard, and R. T. Webb, “Sex- and age-specific incidence of fractures in mental illness: a historical, population-based cohort study,” Journal of Clinical Psychiatry, vol. 69, no. 9, pp. 1398–1403, 2008.
- P. Vestergaard, L. Rejnmark, and L. Mosekilde, “Anxiolytics and sedatives and risk of fractures: effects of half-life,” Calcified Tissue International, vol. 82, no. 1, pp. 34–43, 2008.
- C. V. Tyler Jr., C. W. Snyder, and S. Zyzanski, “Screening for osteoporosis in community-dwelling adults with mental retardation,” Mental Retardation, vol. 38, no. 4, pp. 316–321, 2000.
- D. U. Jung, R. R. Conley, D. L. Kelly et al., “Prevalence of bone mineral density loss in Korean patients with schizophrenia: a cross-sectional study,” Journal of Clinical Psychiatry, vol. 67, no. 9, pp. 1391–1396, 2006.
- M. Hummer, P. Malik, R. W. Gasser et al., “Osteoporosis in patients with schizophrenia,” American Journal of Psychiatry, vol. 162, no. 1, pp. 162–167, 2005.
- U. Halbreich, N. Rojansky, S. Palter et al., “Decreased bone mineral density in medicated psychiatric patients,” Psychosomatic Medicine, vol. 57, no. 5, pp. 485–491, 1995.
- H. Hafner, W. an der Heiden, S. Behrens et al., “Causes and consequences of the gender difference in age at onset of schizophrenia,” Schizophrenia Bulletin, vol. 24, no. 1, pp. 99–113, 1998.
- M. Hummer and J. Huber, “Hyperprolactinaemia and antipsychotic therapy in schizophrenia,” Current Medical Research and Opinion, vol. 20, no. 2, pp. 189–197, 2004.
- S. L. Hui, C. W. Slemenda, and C. C. Johnston, “Age and bone mass as predictors of fracture in a prospective study,” Journal of Clinical Investigation, vol. 81, no. 6, pp. 1804–1809, 1988.
- J. A. Cauley, “Defining ethnic and racial differences in osteoporosis and fragility fractures,” Clinical Orthopaedics and Related Research, vol. 469, no. 7, pp. 1891–1899, 2011.
- J. K. Rybakowski, M. Dmitrzak-Weglarz, P. Kapelski, and J. Hauser, “Functional-1149 g/t polymorphism of the prolactin gene in schizophrenia,” Neuropsychobiology, vol. 65, no. 1, pp. 41–44, 2012.
- J. C. Shim, D. U. Jung, S. S. Jung et al., “Adjunctive varenicline treatment with antipsychotic medications for cognitive impairments in people with schizophrenia: a randomized double-blind placebo-controlled trial,” Neuropsychopharmacology, vol. 37, no. 3, pp. 660–668, 2012.
- H. Liu, N. M. Paige, C. L. Goldzweig et al., “Screening for osteoporosis in men: a systematic review for an american college of physicians guideline,” Annals of Internal Medicine, vol. 148, no. 9, pp. 685–701, 2008.
- F. Dickerson, C. R. Stallings, A. E. Origoni et al., “Cigarette smoking among persons with schizophrenia or bipolar disorder in routine clinical settings, 1999–2011,” Psychiatric Services, vol. 64, no. 1, pp. 44–50, 2013.
- H. W. Daniell, “Osteoporosis of the slender smoker. Vertebral compression fractures and loss of metacarpal cortex in relation to postmenopausal cigarette smoking and lack of obesity,” Archives of Internal Medicine, vol. 136, no. 3, pp. 298–304, 1976.
- M. R. Law and A. K. Hackshaw, “A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect,” British Medical Journal, vol. 315, no. 7112, pp. 841–846, 1997.
- M. Pekkinen, H. Viljakainen, E. Saarnio, C. Lamberg-Allardt, and O. Mäkitie, “Vitamin D is a major determinant of bone mineral density at school age,” PLoS One, vol. 7, no. 7, Article ID e40090, 2012.
- M. E. Molitch, “Medication-induced hyperprolactinemia,” Mayo Clinic Proceedings, vol. 80, no. 8, pp. 1050–1057, 2005.
- C. Bushe, M. Shaw, and R. C. Peveler, “A review of the association between antipsychotic use and hyperprolactinaemia.,” Journal of Psychopharmacology, vol. 22, supplement 2, pp. 46–55, 2008.
- M. M. Carvalho and C. Gois, “Hyperprolactinemia in mentally ill patients,” Acta Médica Portuguesa, vol. 24, no. 6, pp. 1005–1012, 2011.
- P. A. Marken, R. F. Haykal, and J. N. Fisher, “Management of psychotropic-induced hyperprolactinemia,” Clinical Pharmacy, vol. 11, no. 10, pp. 851–856, 1992.
- J. M. Jerrell, J. Bacon, J. T. Burgis, and S. Menon, “Hyperprolactinemia-related adverse events associated with antipsychotic treatment in children and adolescents,” Journal of Adolescent Health, vol. 45, no. 1, pp. 70–76, 2009.
- Y. Roke, P. N. Van Harten, A. M. Boot, and J. K. Buitelaar, “Antipsychotic medication in children and adolescents: a descriptive review of the effects on prolactin level and associated side effects,” Journal of Child and Adolescent Psychopharmacology, vol. 19, no. 4, pp. 403–414, 2009.
- J. Montgomery, E. Winterbottom, M. Jessani et al., “Prevalence of hyperprolactinemia in schizophrenia: association with typical and atypical antipsychotic treatment,” Journal of Clinical Psychiatry, vol. 65, no. 11, pp. 1491–1498, 2004.
- I. R. Falconer, J. V. Langley, and A. T. Vacek, “Effect of prolactin on 86Rb+ uptake, potassium content and [G-3H]ouabain binding of lactating rabbit mammary tissue,” Journal of Physiology, vol. 334, pp. 1–17, 1983.
- M. Jaber, S. W. Robinson, C. Missale, and M. G. Caron, “Dopamine receptors and brain function,” Neuropharmacology, vol. 35, no. 11, pp. 1503–1519, 1996.
- P. M. Haddad and A. Wieck, “Antipsychotic-induced hyperprolactinaemia: mechanisms, clinical features and management,” Drugs, vol. 64, no. 20, pp. 2291–2314, 2004.
- R. A. Bressan, K. Erlandsson, E. P. Spencer, P. J. Ell, and L. S. Pilowsky, “Prolactinemia is uncoupled from central D2/D3 dopamine receptor occupancy in amisulpride treated patients,” Psychopharmacology, vol. 175, no. 3, pp. 367–373, 2004.
- M. Markianos, J. Hatzimanolis, and L. Lykouras, “Neuroendocrine responsivities of the pituitary dopamine system in male schizophrenic patients during treatment with clozapine, olanzapine, risperidone, sulpiride, or haloperidol,” European Archives of Psychiatry and Clinical Neuroscience, vol. 251, no. 3, pp. 141–146, 2001.
- R. Arakawa, M. Okumura, H. Ito et al., “Positron emission tomography measurement of dopamine D2 receptor occupancy in the pituitary and cerebral cortex: relation to antipsychotic-induced hyperprolactinemia,” Journal of Clinical Psychiatry, vol. 71, no. 9, pp. 1131–1137, 2010.
- T. Baptista, A. Lacruz, T. Meza et al., “Antipsychotic drugs and obesity: is prolactin involved?” Canadian Journal of Psychiatry, vol. 46, no. 9, pp. 829–834, 2001.
- D. Seriwatanachai, K. Thongchote, N. Charoenphandhu et al., “Prolactin directly enhances bone turnover by raising osteoblast-expressed receptor activator of nuclear factor κB ligand/osteoprotegerin ratio,” Bone, vol. 42, no. 3, pp. 535–546, 2008.
- K. J. Motyl, I. Dick-de-Paula, A. E. Maloney, et al., “Trabecular bone loss after administration of the second-generation antipsychotic risperidone is independent of weight gain,” Bone, vol. 50, no. 2, pp. 490–498, 2012.
- S. Puntheeranurak, N. Charoenphandhu, and N. Krishnamra, “Enhanced trabecular-bone calcium deposition in female rats with a high physiological dose of prolactin diminishes after ovariectomy,” Canadian Journal of Physiology and Pharmacology, vol. 84, no. 10, pp. 993–1001, 2006.
- P. Clément-Lacroix, C. Ormandy, L. Lepescheux et al., “Osteoblasts are a new target for prolactin: analysis of bone formation in prolactin receptor knockout mice,” Endocrinology, vol. 140, no. 1, pp. 96–105, 1999.
- T. J. Martin and M. T. Gillespie, “Receptor activator of nuclear factor κB ligand (RANKL): another link between breast and bone,” Trends in Endocrinology and Metabolism, vol. 12, no. 1, pp. 2–4, 2001.
- S. M. Graham, D. Howgate, W. Anderson et al., “Risk of osteoporosis and fracture incidence in patients on antipsychotic medication,” Expert Opinion on Drug Safety, vol. 10, no. 4, pp. 575–602, 2011.
- A. M. Meaney and V. O'Keane, “Prolactin and schizophrenia: clinical consequences of hyperprolactinaemia,” Life Sciences, vol. 71, no. 9, pp. 979–992, 2002.
- K. Bácsi, J. P. Kósa, G. Borgulya et al., “CYP3A7*1C polymorphism, serum dehydroepiandrosterone sulfate level, and bone mineral density in postmenopausal women,” Calcified Tissue International, vol. 80, no. 3, pp. 154–159, 2007.
- S. Sherman, “Preventing and treating osteoporosis: strategies at the millennium,” Annals of the New York Academy of Sciences, vol. 949, pp. 188–197, 2001.
- N. B. Watts, “Therapies to improve bone mineral density and reduce the risk of fracture: clinical trial results,” Journal of Reproductive Medicine for the Obstetrician and Gynecologist, vol. 47, supplement 1, pp. 82–92, 2002.
- M. A. Rodriguez-Martinez and E. C. Garcia-Cohen, “Role of Ca(2+) and vitamin D in the prevention and treatment of osteoporosis,” Pharmacology & Therapeutics, vol. 93, no. 1, pp. 37–49, 2002.
- S. R. Marder, S. M. Essock, A. L. Miller, et al., “Physical health monitoring of patients with schizophrenia,” American Journal of Psychiatry, vol. 161, no. 8, pp. 1334–1349, 2004.
- R. C. Peveler, D. Branford, L. Citrome, et al., “Antipsychotics and hyperprolactinaemia: clinical recommendations,” Journal of Psychopharmacology, vol. 22, supplement 2, pp. 98–103, 2008.
- M. J. Stampfer, G. A. Colditz, and W. C. Willett, “Menopause and heart disease: a review,” Annals of the New York Academy of Sciences, vol. 592, pp. 193–203, 1990.
- J. C. Shim, J. G. K. Shin, D. L. Kelly et al., “Adjunctive treatment with a dopamine partial agonist, aripiprazole, for antipsychotic-induced hyperprolactinemia: a placebo-controlled trial,” American Journal of Psychiatry, vol. 164, no. 9, pp. 1404–1410, 2007.
- A. Mir, K. Shivakumar, R. J. Williamson, V. McAllister, V. O'Keane, and K. J. Aitchison, “Change in sexual dysfunction with aripiprazole: a switching or add-on study,” Journal of Psychopharmacology, vol. 22, no. 3, pp. 244–253, 2008.
- A. C. Hergenroeder, “Bone mineralization, hypothalamic amenorrhea, and sex steroid therapy in female adolescents and young adults,” Journal of Pediatrics, vol. 126, no. 5, part 1, pp. 683–689, 1995.
- B. Gulekli, M. C. Davies, and H. S. Jacobs, “Effect of treatment on established osteoporosis in young women with amenorrhoea,” Clinical Endocrinology, vol. 41, no. 3, pp. 275–281, 1994.
- D. Seriwatanachai, N. Krishnamra, and J. P. T. M. Van Leeuwen, “Evidence for direct effects of prolactin on human osteoblasts: inhibition of cell growth and mineralization,” Journal of Cellular Biochemistry, vol. 107, no. 4, pp. 677–685, 2009.