Table 1: Studies evaluating the association of OPG levels with indices of glycemic control, subclinical atherosclerosis, or cardiovascular events in diabetic patients.

StudyPopulationResults

Olesen et al., 2005 [28]21 type 1/type 2 patientsIncreased OPG levels in the aortic tunica media are associated with vascular calcifications
Browner et al., 2001 [37]35 type 2 patientsOPG is associated with cardiovascular mortality
Avignon et al., 2007 [51]465 type 1/type 2 patientsOPG is associated with silent myocardial ischemia
Rasmussen et al., 2006 [52]400 type 1 patientsOPG is associated with poor glycemic control and CVD
Blazquez-Medela et al., 2012 [53]52 type 2 patientsOPG is an indicator of endothelial dysfunction and CVD risk
Altinova et al., 2011 [57]166 type 2 patientsOPG is associated with poor glycemic control and microalbuminuria
Grauslund et al., 2010 [58]200 type 1 patientsOPG is associated with nephropathy
Poulsen et al., 2011 [61]735 type 2 patientsOPG is associated with carotid and peripheral arterial disease
Ishiyama et al., 2009 [62]168 type 2 patientsOPG is positively associated with vascular calcifications and CIMT
Shin et al., 2006 [63]104 type 2 patientsOPG levels are associated with endothelial dysfunction
Terekeci et al., 2009 [64]42 type 2 patientsOPG levels are associated with neuropathy
Xiang et al., 2007 [70]22 type 1 patientsOPG are associated with endothelial function