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International Journal of Endocrinology
Volume 2013 (2013), Article ID 204164, 12 pages
http://dx.doi.org/10.1155/2013/204164
Review Article

Sarcopenic Obesity and Endocrinal Adaptation with Age

1Research Center for Physical Fitness, Sports and Health, Toyohashi University of Technology, 1-1 Hibarigaoka, Tenpaku-cho, Toyohashi 441-8580, Japan
2School of Dentistry, Health Sciences University of Hokkaido, Kanazawa, Ishikari-Tobetsu, Hokkaido 061-0293, Japan

Received 29 November 2012; Accepted 1 March 2013

Academic Editor: Marco A. Minetto

Copyright © 2013 Kunihiro Sakuma and Akihiko Yamaguchi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. G. Candow and P. D. Chilibeck, “Differences in size, strength, and power of upper and lower body muscle groups in young and older men,” The Journals of Gerontology A, vol. 60, no. 2, pp. 148–156, 2005. View at Scopus
  2. L. J. Melton III, S. Khosla, C. S. Crowson, M. K. O'Connor, W. M. O'Fallon, and B. L. Riggs, “Epidemiology of sarcopenia,” Journal of the American Geriatrics Society, vol. 48, no. 6, pp. 625–630, 2000.
  3. R. N. Baumgartner, D. L. Waters, D. Gallagher, J. E. Morley, and P. J. Garry, “Predictors of skeletal muscle mass in elderly men and women,” Mechanisms of Ageing and Development, vol. 107, no. 2, pp. 123–136, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. E. T. Poehlman, M. J. Toth, and T. Fonong, “Exercise, substrate utilization and energy requirements in the elderly,” International Journal of Obesity, vol. 19, supplement 4, pp. S93–S96, 1995. View at Scopus
  5. R. D. Griffiths, “Muscle mass, survival, and the elderly ICU patient,” Nutrition, vol. 12, no. 6, pp. 456–458, 1996. View at Publisher · View at Google Scholar · View at Scopus
  6. T. S. Han, A. Tajar, and M. E. J. Lean, “Obesity and weight management in the elderly,” British Medical Bulletin, vol. 97, no. 1, pp. 169–196, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. Population Projections 2008–2060.
  8. I. Janssen, D. S. Shepard, P. T. Katzmarzyk, and R. Roubenoff, “The healthcare costs of sarcopenia in the United States,” Journal of the American Geriatrics Society, vol. 52, no. 1, pp. 80–85, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. K. R. Short and K. S. Nair, “The effect of age on protein metabolism,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 3, no. 1, pp. 39–44, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. K. R. Short, J. L. Vittone, M. L. Bigelow, D. N. Proctor, and K. S. Nair, “Age and aerobic exercise training effects on whole body and muscle protein metabolism,” American Journal of Physiology—Endocrinology and Metabolism, vol. 286, no. 1, pp. E92–E101, 2004. View at Scopus
  11. J. Lexell, “Human aging, muscle mass, and fiber type composition,” The Journals of Gerontology A, vol. 50, pp. 11–16, 1995. View at Scopus
  12. L. Larsson, “Morphological and functional characteristics of the ageing skeletal muscle in man. A cross-sectional study,” Acta Physiologica Scandinavica, Supplement, vol. 457, pp. 1–36, 1978. View at Scopus
  13. L. B. Verdijk, B. G. Gleeson, R. A. M. Jonkers et al., “Skeletal muscle hypertrophy following resistance training is accompanied by a fiber type-specific increase in satellite cell content in elderly men,” The Journals of Gerontology A, vol. 64, no. 3, pp. 332–339, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. I. M. Conboy, M. J. Conboy, G. M. Smythe, and T. A. Rando, “Notch-mediated restoration of regenerative potential to aged muscle,” Science, vol. 302, no. 5650, pp. 1575–1577, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Day, G. Shefer, A. Shearer, and Z. Yablonka-Reuveni, “The depletion of skeletal muscle satellite cells with age is concomitant with reduced capacity of single progenitors to produce reserve progeny,” Developmental Biology, vol. 340, no. 2, pp. 330–343, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. A. J. Wagers and I. M. Conboy, “Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesis,” Cell, vol. 122, no. 5, pp. 659–667, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Dubé and B. H. Goodpaster, “Assessment of intramuscular triglycerides: contribution to metabolic abnormalities,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 9, no. 5, pp. 553–559, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. E. W. Kraegen and G. J. Cooney, “Free fatty acids and skeletal muscle insulin resistance,” Current Opinion in Lipidology, vol. 19, no. 3, pp. 235–241, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. G. Shefer, M. Wleklinski-Lee, and Z. Yablonka-Reuveni, “Skeletal muscle satellite cells can spontaneously enter an alternative mesenchymal pathway,” Journal of Cell Science, vol. 117, no. 22, pp. 5393–5404, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. M. T. Hamilton, E. Areiqat, D. G. Hamilton, and L. Bey, “Plasma triglyceride metabolism in humans and rats during aging and physical inactivity,” International Journal of Sport Nutrition and Exercise Metabolism, vol. 11, pp. S97–S104, 2001. View at Scopus
  21. J. Lexell, “Ageing and human muscle: observations from Sweden,” Canadian Journal of Applied Physiology, vol. 18, no. 1, pp. 2–18, 1993. View at Scopus
  22. R. Roubenoff and V. A. Hughes, “Sarcopenia: current concepts,” The Journals of Gerontology A, vol. 55, no. 12, pp. M716–M724, 2000. View at Scopus
  23. K. Sakuma and A. Yamaguchi, “Inhibitors of myostatin- and proteasome-dependent signaling for attenuating muscle wasting,” Recent Patent of Regenerative Medicine, vol. 1, no. 3, pp. 284–298, 2011. View at Publisher · View at Google Scholar
  24. K. Sakuma and A. Yamaguchi, “Sarcopenia: molecular mechanisms and current therapeutic strategy,” in Cell Aging, J. W. Perloft and A. H. Wong, Eds., pp. 93–152, Nova Science, New York, NY, USA, 2011.
  25. K. M. Flegal, M. D. Carroll, C. L. Ogden, and L. R. Curtin, “Prevalence and trends in obesity among US adults, 1999–2008,” Journal of the American Medical Association, vol. 303, no. 3, pp. 235–241, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. T. M. Bellanger and G. A. Bray, “Obesity related morbidity and mortality,” The Journal of the Louisiana State Medical Society, vol. 157, no. 1, pp. S42–S49, 2005. View at Scopus
  27. S. Klein, L. E. Burke, G. A. Bray et al., “Clinical implications of obesity with specific focus on cardiovascular disease: a statement for professionals from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: endorsed by the American College of Cardiology Foundation,” Circulation, vol. 110, no. 18, pp. 2952–2967, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. E. E. Calle, M. J. Thun, J. M. Petrelli, C. Rodriguez, and C. W. Heath, “Body-mass index and mortality in a prospective cohort of U.S. adults,” The New England Journal of Medicine, vol. 341, no. 15, pp. 1097–1105, 1999. View at Publisher · View at Google Scholar · View at Scopus
  29. R. L. Kennedy, K. Chokkalingham, and R. Srinivasan, “Obesity in the elderly: who should we be treating, and why, and how?” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 7, no. 1, pp. 3–9, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. D. T. Villareal, C. M. Apovian, R. F. Kushner, and S. Klein, “Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society,” American Journal of Clinical Nutrition, vol. 82, no. 5, pp. 923–934, 2005. View at Scopus
  31. E. L. Lim, K. G. Hollingsworth, B. S. Aribisala, M. J. Chen, J. C. Mathers, and R. Taylor, “Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol,” Diabetologia, vol. 54, no. 10, pp. 2506–2514, 2011. View at Publisher · View at Google Scholar
  32. D. Chau, L. M. Cho, P. Jani, and S. T. St Jeor, “Individualizing recommendations for weight management in the elderly,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 11, no. 1, pp. 27–31, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. B. H. Goodpaster, S. Krishnaswami, T. B. Harris et al., “Obesity, regional body fat distribution, and the metabolic syndrome in older men and women,” Archives of Internal Medicine, vol. 165, no. 7, pp. 777–783, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. H. Bokura, S. Yamaguchi, K. Iijima, A. Nagai, and H. Oguro, “Metabolic syndrome is associated with silent ischemic brain lesions,” Stroke, vol. 39, no. 5, pp. 1607–1609, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. A. L. Bui, T. B. Horwich, and G. C. Fonarow, “Epidemiology and risk profile of heart failure,” Nature Reviews Cardiology, vol. 8, no. 1, pp. 30–41, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. J. Harrington and T. Lee-Chiong, “Obesity and aging,” Clinics in Chest Medicine, vol. 30, no. 3, pp. 609–614, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. K. M. McTigue, R. Hess, and J. Ziouras, “Obesity in older adults: a systematic review of the evidence for diagnosis and treatment,” Obesity, vol. 14, no. 9, pp. 1485–1497, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. L. H. McCarthy, M. E. Bigal, M. Katz, C. Derby, and R. B. Lipton, “Chronic pain and obesity in elderly people: results from the Einstein aging study,” Journal of the American Geriatrics Society, vol. 57, no. 1, pp. 115–119, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. R. N. Baumgartner, “Body composition in healthy aging,” Annals of the New York Academy of Sciences, vol. 904, pp. 437–448, 2000. View at Scopus
  40. D. R. Bouchard, W. Pickett, and I. Janssen, “Association between obesity and unintentional injury in older adults,” Obesity Facts, vol. 3, no. 6, pp. 363–369, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. C. S. Blaum, Q. L. Xue, E. Michelon, R. D. Semba, and L. P. Fried, “The association between obesity and the frailty syndrome in older women: the Women's Health and Aging Studies,” Journal of the American Geriatrics Society, vol. 53, no. 6, pp. 927–934, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. R. Roubenoff, “Sarcopenic obesity: the confluence of two epidemics,” Obesity Research, vol. 12, no. 6, pp. 887–888, 2004. View at Scopus
  43. M. A. Schrager, E. J. Metter, E. Simonsick et al., “Sarcopenic obesity and inflammation in the InCHIANTI study,” Journal of Applied Physiology, vol. 102, no. 3, pp. 919–925, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. R. H. Unger, “Longevity, lipotoxicity and leptin: the adipocyte defense against feasting and famine,” Biochimie, vol. 87, no. 1, pp. 57–64, 2005. View at Publisher · View at Google Scholar · View at Scopus
  45. H. Tilg and A. R. Moschen, “Adipocytokines: mediators linking adipose tissue, inflammation and immunity,” Nature Reviews Immunology, vol. 6, no. 10, pp. 772–783, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. K. E. Wellen and G. S. Hotamisligil, “Inflammation, stress, and diabetes,” The Journal of Clinical Investigation, vol. 115, no. 5, pp. 1111–1119, 2005. View at Publisher · View at Google Scholar · View at Scopus
  47. I. Kratchmarova, D. E. Kalume, B. Blagoev et al., “A proteomic approach for identification of secreted proteins during the differentiation of 3T3-L1 preadipocytes to adipocytes,” Molecular & Cellular Proteomics, vol. 1, no. 3, pp. 213–222, 2002. View at Scopus
  48. Y. Lin, M. W. Rajala, J. P. Berger, D. E. Moller, N. Barzilai, and P. E. Scherer, “Hyperglycemia-induced production of acute phase reactants in adipose tissue,” The Journal of Biological Chemistry, vol. 276, no. 45, pp. 42077–42083, 2001. View at Publisher · View at Google Scholar · View at Scopus
  49. V. Catalán, J. Gómez-Ambrosi, A. Rodríguez, et al., “Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans,” Journal of Molecular Medicine, vol. 87, no. 8, pp. 803–813, 2009. View at Publisher · View at Google Scholar
  50. Q. W. Yan, Q. Yang, N. Mody et al., “The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance,” Diabetes, vol. 56, no. 10, pp. 2533–2540, 2007. View at Publisher · View at Google Scholar · View at Scopus
  51. J. Zhang, Y. Wu, Y. Zhang, D. Leroith, D. A. Bernlohr, and X. Chen, “The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages,” Molecular Endocrinology, vol. 22, no. 6, pp. 1416–1426, 2008. View at Publisher · View at Google Scholar · View at Scopus
  52. J. B. Cowland, T. Muta, and N. Borregaard, “IL-1β-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IκB-ζ,” Journal of Immunology, vol. 176, no. 9, pp. 5559–5566, 2006. View at Scopus
  53. L. A. Meheus, L. M. Fransen, J. G. Raymackers et al., “Identification by microsequencing of lipopolysaccharide-induced proteins secreted by mouse macrophages,” Journal of Immunology, vol. 151, no. 3, pp. 1535–1547, 1993. View at Scopus
  54. I. K. M. Law, A. Xu, K. S. L. Lam, et al., “Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity,” Diabetes, vol. 59, no. 4, pp. 872–882, 2010. View at Publisher · View at Google Scholar
  55. R. J. Urban, Y. H. Bodenburg, C. Gilkison et al., “Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis,” American Journal of Physiology—Endocrinology and Metabolism, vol. 269, no. 5, pp. E820–E826, 1995. View at Scopus
  56. S. Bhasin, L. Woodhouse, and T. W. Storer, “Proof of the effect of testosterone on skeletal muscle,” Journal of Endocrinology, vol. 170, no. 1, pp. 27–38, 2001. View at Publisher · View at Google Scholar · View at Scopus
  57. H. A. Feldman, C. Longcope, C. A. Derby et al., “Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts Male Aging Study,” The Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 2, pp. 589–598, 2002. View at Publisher · View at Google Scholar · View at Scopus
  58. J. E. Morley, F. E. Kaiser, H. M. Perry et al., “Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men,” Metabolism, vol. 46, no. 4, pp. 410–413, 1997. View at Publisher · View at Google Scholar · View at Scopus
  59. J. E. Morley and H. M. Perry, “Androgens and women at the menopause and beyond,” The Journals of Gerontology A, vol. 58, no. 5, pp. M409–M416, 2003.
  60. J. R. Florini, D. Z. Ewton, and S. A. Coolican, “Growth hormone and the insulin-like growth factor system in myogenesis,” Endocrine Reviews, vol. 17, no. 5, pp. 481–517, 1996. View at Publisher · View at Google Scholar · View at Scopus
  61. K. Y. Ho, J. D. Veldhuis, M. L. Johnson et al., “Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man,” The Journal of Clinical Investigation, vol. 81, no. 4, pp. 968–975, 1988. View at Scopus
  62. A. Moran, D. R. Jacobs, J. Steinberger et al., “Association between the insulin resistance of puberty and the insulin-like growth factor-I/growth hormone axis,” The Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 10, pp. 4817–4820, 2002. View at Publisher · View at Google Scholar · View at Scopus
  63. M. Hermann and P. Berger, “Hormonal changes in aging men: a therapeutic indication?” Experimental Gerontology, vol. 36, no. 7, pp. 1075–1082, 2001. View at Publisher · View at Google Scholar · View at Scopus
  64. J. G. Ryall, J. D. Schertzer, and G. S. Lynch, “Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness,” Biogerontology, vol. 9, no. 4, pp. 213–228, 2008. View at Publisher · View at Google Scholar · View at Scopus
  65. S. Giovannini, E. Marzetti, S. E. Borst, and C. Leeuwenburgh, “Modulation of GH/IGF-1 axis: potential strategies to counteract sarcopenia in older adults,” Mechanisms of Ageing and Development, vol. 129, no. 10, pp. 593–601, 2008. View at Publisher · View at Google Scholar · View at Scopus
  66. R. Nass, G. Johannsson, J. S. Christiansen, J. J. Kopchick, and M. O. Thorner, “The aging population—is there a role for endocrine interventions?” Growth Hormone and IGF Research, vol. 19, no. 2, pp. 89–100, 2009. View at Publisher · View at Google Scholar · View at Scopus
  67. K. Sakuma and A. Yamaguchi, “Molecular mechanisms in aging and current strategies to counteract sarcopenia,” Current Aging Science, vol. 3, no. 2, pp. 90–101, 2010. View at Publisher · View at Google Scholar · View at Scopus
  68. P. J. Campbell, M. G. Carlson, and N. Nurjhan, “Fat metabolism in human obesity,” American Journal of Physiology—Endocrinology and Metabolism, vol. 266, no. 4, pp. E600–E605, 1994. View at Scopus
  69. K. F. Petersen, D. Befroy, S. Dufour et al., “Mitochondrial dysfunction in the elderly: possible role in insulin resistance,” Science, vol. 300, no. 5622, pp. 1140–1142, 2003. View at Publisher · View at Google Scholar · View at Scopus
  70. P. S. van Dam, H. E. C. Smid, W. R. de Vries et al., “Reduction of free fatty acids by acipimox enhances the growth hormone (GH) responses to GH-releasing peptide 2 in elderly men,” The Journal of Clinical Endocrinology and Metabolism, vol. 85, no. 12, pp. 4706–4711, 2000. View at Publisher · View at Google Scholar · View at Scopus
  71. A. Weltman, J. Y. Weltman, J. D. Veldhuis, and M. L. Hartman, “Body composition, physical exercise, growth hormone and obesity,” Eating and Weight Disorders, vol. 6, no. 3, pp. 28–37, 2001. View at Scopus
  72. D. L. Waters, C. R. Qualls, R. I. Dorin, J. D. Veldhuis, and R. N. Baumgartner, “Altered growth hormone, cortisol, and leptin secretion in healthy elderly persons with sarcopenia and mixed body composition phenotypes,” The Journals of Gerontology A, vol. 63, no. 5, pp. 536–541, 2008. View at Scopus
  73. C. A. Allan, B. J. G. Strauss, and R. I. McLachlan, “Body composition, metabolic syndrome and testosterone in ageing men,” International Journal of Impotence Research, vol. 19, no. 5, pp. 448–457, 2007. View at Publisher · View at Google Scholar · View at Scopus
  74. A. R. Cappola, K. Bandeen-Roche, G. S. Wand, S. Volpato, and L. P. Fried, “Association of IGF-I levels with muscle strength and mobility in older women,” The Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 9, pp. 4139–4146, 2001. View at Publisher · View at Google Scholar · View at Scopus
  75. L. A. Schaap, S. M. F. Pluijm, J. H. Smitt et al., “The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women,” Clinical Endocrinology, vol. 63, no. 2, pp. 152–160, 2005. View at Publisher · View at Google Scholar · View at Scopus
  76. L. W. Chu, S. Tam, A. W. C. Kung et al., “Serum total and bioavailable testosterone levels, central obesity, and muscle strength changes with aging in healthy Chinese men,” Journal of the American Geriatrics Society, vol. 56, no. 7, pp. 1286–1291, 2008. View at Publisher · View at Google Scholar · View at Scopus
  77. A. M. Umpleby and D. L. Russell-Jones, “The hormonal control of protein metabolism,” Bailliére’s Clinical Endocrinology and Metabolism, vol. 10, no. 4, pp. 551–570, 1996. View at Publisher · View at Google Scholar
  78. J. M. Carrascosa, A. Andrés, M. Ros et al., “Development of insulin resistance during aging: involvement of central processes and role of adipokines,” Current Protein and Peptide Science, vol. 12, no. 4, pp. 305–315, 2011. View at Publisher · View at Google Scholar · View at Scopus
  79. K. L. Timmerman and E. Volpi, “Endothelial function and the regulation of muscle protein anabolism in older adults,” Nutrition, Metabolism and Cardiovascular Diseases, 2012. View at Publisher · View at Google Scholar
  80. M. A. Vincent, M. Montagnani, and M. J. Quon, “Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium,” Current Diabetes Reports, vol. 3, no. 4, pp. 279–288, 2003. View at Scopus
  81. S. Fujita, E. L. Glynn, K. L. Timmerman, B. B. Rasmussen, and E. Volpi, “Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism,” Diabetologia, vol. 52, no. 9, pp. 1889–1898, 2009. View at Publisher · View at Google Scholar · View at Scopus
  82. I. Gabriely, X. H. Ma, X. M. Yang et al., “Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?” Diabetes, vol. 51, no. 10, pp. 2951–2958, 2002. View at Scopus
  83. R. Basu, E. Breda, A. L. Oberg et al., “Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance,” Diabetes, vol. 52, no. 7, pp. 1738–1748, 2003. View at Scopus
  84. L. J. C. van Loon and B. H. Goodpaster, “Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state,” Pflügers Archeiv, vol. 451, no. 5, pp. 606–616, 2006. View at Publisher · View at Google Scholar · View at Scopus
  85. R. Roubenoff, “Catabolism of aging: is it an inflammatory process?” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 6, no. 3, pp. 295–299, 2003. View at Publisher · View at Google Scholar · View at Scopus
  86. L. A. Schaap, S. M. F. Pluijm, D. J. H. Deeg et al., “Higher inflammatory marker levels in older persons: associations with 5-year change in muscle mass and muscle strength,” The Journals of Gerontology A, vol. 64, no. 11, pp. 1183–1189, 2009. View at Publisher · View at Google Scholar · View at Scopus
  87. I. Rieu, H. Magne, I. Savary-Auzeloux et al., “Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats,” The Journal of Physiology, vol. 587, no. 22, pp. 5483–5492, 2009. View at Publisher · View at Google Scholar · View at Scopus
  88. H. Y. Chung, M. Cesari, S. Anton et al., “Molecular inflammation: underpinnings of aging and age-related diseases,” Ageing Research Reviews, vol. 8, no. 1, pp. 18–30, 2009. View at Publisher · View at Google Scholar · View at Scopus
  89. M. B. Reid and Y. P. Li, “Tumor necrosis factor-α and muscle wasting: a cellular perspective,” Respiratory Research, vol. 2, no. 5, pp. 269–272, 2001. View at Publisher · View at Google Scholar · View at Scopus
  90. W. Aoi and K. Sakuma, “Oxidative stress and skeletal muscle dysfunction with aging,” Current Aging Science, vol. 4, no. 2, pp. 101–109, 2011. View at Scopus
  91. S. J. Meng and L. J. Yu, “Oxidative stress, molecular inflammation and sarcopenia,” International Journal of Molecular Sciences, vol. 11, no. 4, pp. 1509–1526, 2010. View at Publisher · View at Google Scholar · View at Scopus
  92. M. Bar-Shai, E. Carmeli, R. Coleman et al., “The effect of hindlimb immobilization on acid phosphatase, metalloproteinases and nuclear factor-κB in muscles of young and old rats,” Mechanisms of Ageing and Development, vol. 126, no. 2, pp. 289–297, 2005. View at Publisher · View at Google Scholar · View at Scopus
  93. T. Phillips and C. Leeuwenburgh, “Muscle fiber specific apoptosis and TNF-α signaling in sarcopenia are attenuated by life-long calorie restriction,” The FASEB Journal, vol. 19, no. 6, pp. 668–670, 2005. View at Publisher · View at Google Scholar · View at Scopus
  94. E. Marzetti, C. S. Carter, S. E. Wohlgemuth et al., “Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction,” Mechanisms of Ageing and Development, vol. 130, no. 4, pp. 272–280, 2009. View at Publisher · View at Google Scholar · View at Scopus
  95. E. E. Pistilli, J. R. Jackson, and S. E. Alway, “Death receptor-associated pro-apoptotic signaling in aged skeletal muscle,” Apoptosis, vol. 11, no. 12, pp. 2115–2126, 2006. View at Publisher · View at Google Scholar · View at Scopus
  96. W. B. Ershler and E. T. Keller, “Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty,” Annual Review of Medicine, vol. 51, pp. 245–270, 2000. View at Publisher · View at Google Scholar · View at Scopus
  97. K. S. Krabbe, M. Pedersen, and H. Bruunsgaard, “Inflammatory mediators in the elderly,” Experimental Gerontology, vol. 39, no. 5, pp. 687–699, 2004. View at Publisher · View at Google Scholar · View at Scopus
  98. A. R. Cappola, Q. L. Xue, L. Ferrucci, J. M. Guralnik, S. Volpato, and L. P. Fried, “Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women,” The Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 5, pp. 2019–2025, 2003. View at Publisher · View at Google Scholar · View at Scopus
  99. L. A. Schaap, S. M. F. Pluijm, D. J. H. Deeg, and M. Visser, “Inflammatory markers and loss of muscle mass (sarcopenia) and strength,” American Journal of Medicine, vol. 119, no. 6, pp. 526.e9–526.e17, 2006. View at Publisher · View at Google Scholar · View at Scopus
  100. D. R. Taaffe, T. B. Harris, L. Ferrucci, J. Rowe, and T. E. Seeman, “Cross-sectional and prospective relationships of interleukin-6 and c-reactive protein with physical performance in elderly persons: macArthur studies of successful aging,” The Journals of Gerontology A, vol. 55, no. 12, pp. M709–M715, 2000. View at Scopus
  101. M. Hamer and G. J. Molloy, “Association of C-reactive protein and muscle strength in the English Longitudinal Study of Ageing,” Age, vol. 31, no. 3, pp. 171–177, 2009. View at Publisher · View at Google Scholar · View at Scopus
  102. F. Haddad, F. Zaldivar, D. M. Cooper, and G. R. Adams, “IL-6-induced skeletal muscle atrophy,” Journal of Applied Physiology, vol. 98, no. 3, pp. 911–917, 2005. View at Publisher · View at Google Scholar · View at Scopus
  103. M. L. Kohut, D. A. McCann, D. W. Russell et al., “Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of β-blockers, BMI, and psychosocial factors in older adults,” Brain, Behavior, and Immunity, vol. 20, no. 3, pp. 201–209, 2006. View at Publisher · View at Google Scholar · View at Scopus
  104. L. K. Stewart, M. G. Flynn, W. W. Campbell et al., “The influence of exercise training on inflammatory cytokines and C-reactive protein,” Medicine and Science in Sports and Exercise, vol. 39, no. 10, pp. 1714–1719, 2007. View at Publisher · View at Google Scholar · View at Scopus
  105. A. C. McPherron, A. M. Lawler, and S. J. Lee, “Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member,” Nature, vol. 387, no. 6628, pp. 83–90, 1997. View at Scopus
  106. K. Sakuma and A. Yamaguchi, “Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass,” Journal of Cachexia, Sarcopenia and Muscle, vol. 3, no. 2, pp. 77–94, 2012. View at Publisher · View at Google Scholar
  107. M. Wehling, B. Cai, and J. G. Tidball, “Modulation of myostatin expression during modified muscle use,” The FASEB Journal, vol. 14, no. 1, pp. 103–110, 2000. View at Scopus
  108. N. F. Gonzalez-Cadavid, W. E. Taylor, K. Yarasheski et al., “Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 25, pp. 14938–14943, 1998. View at Publisher · View at Google Scholar · View at Scopus
  109. T. A. Zimmers, M. V. Davies, L. G. Koniaris et al., “Induction of cachexia in mice by systemically administered myostatin,” Science, vol. 296, no. 5572, pp. 1486–1488, 2002. View at Publisher · View at Google Scholar · View at Scopus
  110. N. K. LeBrasseur, T. M. Schelhorn, B. L. Bernardo, P. G. Cosgrove, P. M. Loria, and T. A. Brown, “Myostatin inhibition enhances the effects of exercise on performance and metabolic outcomes in aged mice,” The Journals of Gerontology A, vol. 64, no. 9, pp. 940–948, 2009. View at Publisher · View at Google Scholar · View at Scopus
  111. K. T. Murphy, R. Koopman, T. Naim et al., “Antibody-directed myostatin inhibition in 21-mo-old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function,” The FASEB Journal, vol. 24, no. 11, pp. 4433–4442, 2010. View at Publisher · View at Google Scholar · View at Scopus
  112. D. L. Allen, D. S. Hittel, and A. C. McPherron, “Expression and function of myostatin in obesity, diabetes, and exercise adaptation,” Medicine and Science in Sports and Exercise, vol. 43, no. 10, pp. 1828–1835, 2011.
  113. N. K. LeBrasseur, K. Walsh, and Z. Arany, “Metabolic benefits of resistance training and fast glycolytic skeletal muscle,” American Journal of Physiology—Endocrinology and Metabolism, vol. 300, no. 1, pp. E3–E10, 2011. View at Publisher · View at Google Scholar · View at Scopus
  114. C. Zhang, C. McFarlane, S. Lokireddy, et al., “Inhibition of myostatin protects against diet-induced obesity through enhancing fatty acid oxidation and promoting brown adipose phenotype in mice,” Diabetologia, vol. 55, no. 1, pp. 183–193, 2011.
  115. I. Akpan, M. D. Goncalves, R. Dhir et al., “The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity,” International Journal of Obesity, vol. 33, no. 11, pp. 1265–1273, 2009. View at Publisher · View at Google Scholar · View at Scopus
  116. B. L. Bernardo, T. S. Wachtmann, P. G. Cosgrove et al., “Postnatal PPARdelta activation and myostatin inhibition exert distinct yet complimentary effects on the metabolic profile of obese insulin-resistant mice,” PLoS one, vol. 5, no. 6, Article ID e11307, 2010. View at Publisher · View at Google Scholar · View at Scopus
  117. A. Ratkevicius, A. Joyson, I. Selmer, et al., “Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic elderly men,” The Journals of Gerontology A, vol. 66, no. 6, pp. 620–626, 2011.
  118. S. E. Wozniak, L. L. Gee, M. S. Wachtel, and E. E. Frezza, “Adipose tissue: the new endocrine organ? a review article,” Digestive Diseases and Sciences, vol. 54, no. 9, pp. 1847–1856, 2009. View at Publisher · View at Google Scholar · View at Scopus
  119. E. Hu, P. Liang, and B. M. Spiegelman, “AdipoQ is a novel adipose-specific gene dysregulated in obesity,” The Journal of Biological Chemistry, vol. 271, no. 18, pp. 10697–10703, 1996. View at Publisher · View at Google Scholar · View at Scopus
  120. L. Barré, C. Richardson, M. F. Hirshman et al., “Genetic model for the chronic activation of skeletal muscle AMP-activated protein kinase leads to glycogen accumulation,” American Journal of Physiology—Endocrinology and Metabolism, vol. 292, no. 3, pp. E802–E811, 2007. View at Publisher · View at Google Scholar · View at Scopus
  121. H. Iwahashi, T. Funahashi, N. Kurokawa et al., “Plasma adiponectin levels in women with anorexia nervosa,” Hormone and Metabolic Research, vol. 35, no. 9, pp. 537–540, 2003. View at Publisher · View at Google Scholar · View at Scopus
  122. R. S. Lindsay, J. D. Walker, P. J. Havel, B. A. Hamilton, A. A. Calder, and F. D. Johnstone, “Adiponectin is present in cord blood but is unrelated to birth weight,” Diabetes Care, vol. 26, no. 8, pp. 2244–2249, 2003. View at Publisher · View at Google Scholar · View at Scopus
  123. M. Matsubara, S. Maruoka, and S. Katayose, “Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women,” European Journal of Endocrinology, vol. 147, no. 2, pp. 173–180, 2002. View at Scopus
  124. T. P. Combs, A. H. Berg, S. Obici, P. E. Scherer, and L. Rossetti, “Endogenous glucose production is inhibited by the adipose-derived protein Acrp30,” The Journal of Clinical Investigation, vol. 108, no. 12, pp. 1875–1881, 2001. View at Publisher · View at Google Scholar · View at Scopus
  125. T. Yamauchi, J. Kamon, H. Waki et al., “The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity,” Nature Medicine, vol. 7, no. 8, pp. 941–946, 2001. View at Publisher · View at Google Scholar · View at Scopus
  126. T. Yamauchi, J. Kamon, Y. Minokoshi et al., “Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase,” Nature Medicine, vol. 8, no. 11, pp. 1288–1295, 2002. View at Publisher · View at Google Scholar · View at Scopus
  127. X. Wu, H. Motoshima, K. Mahadev, T. J. Stalker, R. Scalia, and B. J. Goldstein, “Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes,” Diabetes, vol. 52, no. 6, pp. 1355–1363, 2003. View at Publisher · View at Google Scholar · View at Scopus
  128. C. Debard, M. Laville, V. Berbe et al., “Expression of key genes of fatty acid oxidation, including adiponectin receptors, in skeletal muscle of type 2 diabetic patients,” Diabetologia, vol. 47, no. 5, pp. 917–925, 2004. View at Publisher · View at Google Scholar · View at Scopus
  129. H. Staiger, S. Kaltenbach, K. Staiger et al., “Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism,” Diabetes, vol. 53, no. 9, pp. 2195–2201, 2004. View at Publisher · View at Google Scholar · View at Scopus
  130. M. B. Chen, A. J. McAinch, S. L. Macaulay et al., “Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics,” The Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 6, pp. 3665–3672, 2005. View at Publisher · View at Google Scholar · View at Scopus
  131. N. Vilarrasa, J. Vendrell, J. Maravall et al., “Distribution and determinants of adiponectin, resistin and ghrelin in a randomly selected healthy population,” Clinical Endocrinology, vol. 63, no. 3, pp. 329–335, 2005. View at Publisher · View at Google Scholar · View at Scopus
  132. K. Y. Kim, J. K. Kim, S. H. Han et al., “Adiponectin is a negative regulator of NK cell cytotoxicity,” Journal of Immunology, vol. 176, no. 10, pp. 5958–5964, 2006. View at Scopus
  133. C. Koch, R. A. Augustine, J. Steger et al., “Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity,” The Journal of Neuroscience, vol. 30, no. 48, pp. 16180–16187, 2010. View at Publisher · View at Google Scholar · View at Scopus
  134. B. B. Kahn and J. S. Flier, “Obesity and insulin resistance,” The Journal of Clinical Investigation, vol. 106, no. 4, pp. 473–481, 2000. View at Scopus
  135. R. B. Ceddia, H. A. Koistinen, J. R. Zierath, and G. Sweeney, “Analysis of paradoxical observations on the association between leptin and insulin resistance,” The FASEB Journal, vol. 16, no. 10, pp. 1163–1176, 2002. View at Publisher · View at Google Scholar · View at Scopus
  136. Y. Minokoshi, M. S. Haque, and T. Shimazu, “Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats,” Diabetes, vol. 48, no. 2, pp. 287–291, 1999. View at Publisher · View at Google Scholar · View at Scopus
  137. C. Pérez, C. Fernández-Galaz, T. Fernández-Agulló, et al., “Leptin impairs insulin signaling in rat adipocytes,” Diabetes, vol. 53, no. 2, pp. 347–353, 2004. View at Publisher · View at Google Scholar
  138. J. Rouru, I. Cusin, K. E. Zakrzewska, B. Jeanrenaud, and F. Rohner-Jeanrenaud, “Effects of intravenously infused leptin on insulin sensitivity and on the expression of uncoupling proteins in brown adipose tissue,” Endocrinology, vol. 140, no. 8, pp. 3688–3692, 1999. View at Scopus
  139. P. J. Scarpace, M. Matheny, and N. Tümer, “Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats,” Neuroscience, vol. 104, no. 4, pp. 1111–1117, 2001. View at Publisher · View at Google Scholar · View at Scopus
  140. G. Brabant, G. Müller, R. Horn, C. Anderwald, M. Roden, and H. Nave, “Hepatic leptin signaling in obesity,” The FASEB Journal, vol. 19, no. 8, pp. 1048–1050, 2005. View at Publisher · View at Google Scholar · View at Scopus
  141. C. Fernández-Galaz, T. Fernández-Agulló, C. Pérez, et al., “Long-term food restriction prevents ageing-associated central leptin resistance in Wistar rats,” Diabetologia, vol. 45, no. 7, pp. 997–1003, 2002. View at Publisher · View at Google Scholar
  142. K. Esposito, A. Pontillo, F. Giugliano et al., “Association of low interleukin-10 levels with the metabolic syndrome in obese women,” The Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 3, pp. 1055–1058, 2003. View at Publisher · View at Google Scholar · View at Scopus
  143. B. K. Pedersen, “The diseasome of physical inactivity—and the role of myokines in muscle-fat cross talk,” The Journal of Physiology, vol. 587, no. 23, pp. 5559–5568, 2009. View at Publisher · View at Google Scholar · View at Scopus
  144. R. L. Chelvarajan, S. M. Collins, J. M. van Willigen, and S. Bondada, “The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function,” Journal of Leukocyte Biology, vol. 77, no. 4, pp. 503–512, 2005. View at Publisher · View at Google Scholar · View at Scopus
  145. B. C. Chiu, V. R. Stolberg, and S. W. Chensue, “Mononuclear phagocyte-derived IL-10 suppresses the innate IL-12/IFN-γ axis in lung-challenged aged mice,” Journal of Immunology, vol. 181, no. 5, pp. 3156–3166, 2008. View at Scopus
  146. L. Álvarez-Rodríguez, M. López-Hoyos, P. Muñoz-Cacho, and V. M. Martínez-Taboada, “Aging is associated with circulating cytokine dysregulation,” Cell Immunology, vol. 273, no. 2, pp. 124–132, 2012. View at Publisher · View at Google Scholar
  147. R. J. Forsey, J. M. Thompson, J. Ernerudh, et al., “Plasma cytokine profiles in elderly humans,” Mechanisms of Ageing and Developemnt, vol. 124, no. 4, pp. 487–493, 2003. View at Publisher · View at Google Scholar
  148. S. Pestka, C. D. Krause, D. Sarkar, M. R. Walter, Y. Shi, and P. B. Fisher, “Interleukin-10 and related cytokines and receptors,” Annual Review of Immunology, vol. 22, pp. 929–979, 2004. View at Publisher · View at Google Scholar · View at Scopus
  149. F. Ko, Q.-Y. Xue, W. Yao, et al., “Inflammation and mortality in a frail mouse model,” Age, vol. 34, no. 3, pp. 705–715, 2012. View at Publisher · View at Google Scholar
  150. W. E. Carson, M. J. Lindemann, R. Baiocchi et al., “The functional characterization of interleukin-10 receptor expression on human natural killer cells,” Blood, vol. 85, no. 12, pp. 3577–3585, 1995. View at Scopus
  151. M. A. Stacey, M. Marsden, E. C. Wang, G. W. Wilkinson, and I. R. Humphreys, “IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection,” Journal of Immunology, vol. 187, no. 6, pp. 2944–2952, 2011. View at Publisher · View at Google Scholar
  152. C. T. Lutz and L. S. Quinn, “Sarcopenia, obesity, and natural killer cell immune senescence in aging: altered cytokine levels as a common mechanism,” Aging, vol. 4, no. 8, pp. 535–546, 2012.
  153. K. H. Grabstein, J. Eisenman, K. Shanebeck et al., “Cloning of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor,” Science, vol. 264, no. 5161, pp. 965–968, 1994. View at Scopus
  154. C. Bergamaschi, M. Rosati, R. Jalah et al., “Intracellular interaction of interleukin-15 with its receptor α during production leads to mutual stabilization and increased bioactivity,” The Journal of Biological Chemistry, vol. 283, no. 7, pp. 4189–4199, 2008. View at Publisher · View at Google Scholar · View at Scopus
  155. E. Mortier, T. Woo, R. Advincula, S. Gozalo, and A. Ma, “IL-15Rα chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation,” Journal of Experimental Medicine, vol. 205, no. 5, pp. 1213–1225, 2008. View at Publisher · View at Google Scholar · View at Scopus
  156. L. S. Quinn, “Interleukin-15: a muscle-derived cytokine regulating fat-to-lean body composition,” Journal of Animal Science, vol. 86, supplement 14, pp. E75–E83, 2008. View at Scopus
  157. S. E. Riechman, G. Balasekaran, S. M. Roth, and R. E. Ferrell, “Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses,” Journal of Applied Physiology, vol. 97, no. 6, pp. 2214–2219, 2004. View at Publisher · View at Google Scholar · View at Scopus
  158. Y. Tamura, K. Watanabe, T. Kantani, J. Hayashi, N. Ishida, and M. Kaneki, “Upregulation of circulating IL-15 by treadmill running in healthy individuals: is IL-15 an endocrine mediator of the beneficial effects of endurance exercise?” Endocrine Journal, vol. 58, no. 3, pp. 211–215, 2011. View at Publisher · View at Google Scholar · View at Scopus
  159. L. S. Quinn, B. G. Anderson, L. Strait-Bodey, and T. Wolden-Hanson, “Serum and muscle interleukin-15 levels decrease in aging mice: correlation with declines in soluble interleukin-15 receptor alpha expression,” Experimental Gerontology, vol. 45, no. 2, pp. 106–112, 2010. View at Publisher · View at Google Scholar · View at Scopus
  160. S. Gangemi, G. Basile, D. Monti et al., “Age-related modifications in circulating IL-15 levels in humans,” Mediators of Inflammation, vol. 2005, no. 4, pp. 245–247, 2005. View at Publisher · View at Google Scholar · View at Scopus
  161. N. G. Barra, S. Reid, R. MacKenzie et al., “Interleukin-15 contributes to the regulation of murine adipose tissue and human adipocytes,” Obesity, vol. 18, no. 8, pp. 1601–1607, 2010. View at Publisher · View at Google Scholar · View at Scopus
  162. A. R. Nielsen, P. Hojman, C. Erikstrup et al., “Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass,” The Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 11, pp. 4486–4493, 2008. View at Publisher · View at Google Scholar · View at Scopus
  163. N. G. Barra, M. V. Chew, A. C. Holloway, and A. A. Ashkar, “Interleukin-15 treatment improves glucose homeostasis and insulin sensitivity in obese mice,” Diabetes and Obese Metabolism, vol. 14, no. 2, pp. 190–193, 2012. View at Publisher · View at Google Scholar
  164. B. H. Goodpaster, C. L. Carlson, M. Visser et al., “Attenuation of skeletal muscle and strength in the elderly: the health ABC study,” Journal of Applied Physiology, vol. 90, no. 6, pp. 2157–2165, 2001. View at Scopus
  165. M. Y. Song, E. Ruts, J. Kim, I. Janumala, S. Heymsfield, and D. Gallagher, “Sarcopenia and increased adipose tissue infiltration of muscle in elderly African American women,” American Journal of Clinical Nutrition, vol. 79, no. 5, pp. 874–880, 2004. View at Scopus
  166. E. J. Anderson, M. E. Lustig, K. E. Boyle et al., “Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans,” The Journal of Clinical Investigation, vol. 119, no. 3, pp. 573–581, 2009. View at Publisher · View at Google Scholar · View at Scopus
  167. Z. Arany, S. Y. Foo, Y. Ma et al., “HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α,” Nature, vol. 451, no. 7181, pp. 1008–1012, 2008. View at Publisher · View at Google Scholar · View at Scopus
  168. S. Crunkhorn, F. Dearie, C. Mantzoros et al., “Peroxisome proliferator activator receptor γ coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation,” The Journal of Biological Chemistry, vol. 282, no. 21, pp. 15439–15450, 2007. View at Publisher · View at Google Scholar · View at Scopus
  169. T. Wenz, S. G. Rossi, R. L. Rotundo, B. M. Spiegelman, and C. T. Moraes, “Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 48, pp. 20405–20410, 2009. View at Publisher · View at Google Scholar · View at Scopus
  170. W. L. Haskell, I. M. Lee, R. R. Pate et al., “Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association,” Medicine and Science in Sports and Exercise, vol. 39, no. 8, pp. 1423–1434, 2007. View at Publisher · View at Google Scholar · View at Scopus
  171. C. J. Liu and N. K. Latham, “Progressive resistance strength training for improving physical function in older adults,” Cochrane Database of Systematic Reviews, no. 3, Article ID CD002759, 2009. View at Scopus
  172. L. E. Davidson, R. Hudson, K. Kilpatrick et al., “Effects of exercise modality on insulin resistance and functional limitation in older adults: a randomized controlled trial,” Archives of Internal Medicine, vol. 169, no. 2, pp. 122–131, 2009. View at Publisher · View at Google Scholar · View at Scopus
  173. D. Paddon-Jones and B. B. Rasmussen, “Dietary protein recommendations and the prevention of sarcopenia,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 12, no. 1, pp. 86–90, 2009. View at Publisher · View at Google Scholar · View at Scopus
  174. D. L. Waters, R. N. Baumgartner, P. J. Garry, and B. Vellas, “Advantages of dietary, exercise-related, and therapeutic interventions to prevent and treat sarcopenia in adult patients: an update,” Clinical Interventions in Aging, vol. 5, pp. 259–270, 2010. View at Scopus
  175. H. C. Dreyer, M. J. Drummond, B. Pennings et al., “Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle,” American Journal of Physiology—Endocrinology and Metabolism, vol. 294, no. 2, pp. E392–E400, 2008. View at Publisher · View at Google Scholar · View at Scopus
  176. S. Walrand, C. Guillet, J. Salles, N. Cano, and Y. Boirie, “Physiopathological mechanism of sarcopenia,” Clinics in Geriatric Medicine, vol. 27, no. 3, pp. 365–385, 2011. View at Publisher · View at Google Scholar · View at Scopus
  177. M. Zamboni, G. Mazzali, F. Fantin, A. Rossi, and V. di Francesco, “Sarcopenic obesity: a new category of obesity in the elderly,” Nutrition, Metabolism and Cardiovascular Diseases, vol. 18, no. 5, pp. 388–395, 2008. View at Publisher · View at Google Scholar · View at Scopus