International Journal of Endocrinology

Research Article

Effects of Growth Hormone Replacement Therapy on Bone Mineral Density in Growth Hormone Deficient Adults: A Meta-Analysis

Table 2

BMD measurements and outcomes.


References	DXA scanner manufacturer	BMD sites	CV^aof BMD measurements	Baseline BMD (mean ± SD)	Posttreatment BMD (mean ± SD)	BMD scales	Serum IGF1 changes

Hansen et al., 1996 [13]	Hologic Inc.	Spine FN TB	0.6% 1.4% 1.6%			g/cm²	Increased

Johannsson et al., 1996 [14]	GE-Lunar	Spine FN TB	0.5% 1.6% 0.4%			g/cm²	Increased from to 3μg/L

Rodríguez-Arnao et al., 1998 [15]	Hologic Inc.	Spine FN TB	1.0% 1.8% NA^b			g/cm²	Increased significantly with 31% of the total patients showing IGF1 levels above the age-corrected limit of normal

Cuneo et al., 1998 [16]	GE-Lunar	TB	<3.8%			g/cm²	Increased from 100 to μg/L

Biller et al., 2000 [17]	Hologic Inc.	Spine FN TB	NA NA NA			g/cm²	NA

Koranyi et al., 2001 (1) [18]	GE-Lunar	FN TB	NA NA			g/cm²	Increased from to μg/L

Koranyi et al., 2001 (2) [18]	GE-Lunar	FN TB	NA NA			g/cm²	Increased from to μg/L

Lanzi et al., 2003 [19]	Hologic Inc.	Spine FN	0.5% NA			t-score	Increased from to μg/L

Underwood et al., 2003 (1) [20]	GE-Lunar	Spine	NA			z-score	IGF1 SDS increased from to

Underwood et al., 2003 (2) [20]	GE-Lunar	Spine	NA			z-score	IGF1 SDS increased from to

Hubina et al., 2004 (1) [21]	Hologic Inc.	Spine FN	0.35% NA			t-score	IGF1 SDS increased from to

Hubina et al., 2004 (2) [21]	Hologic Inc.	Spine FN	0.35% NA			t-score	IGF1 SDS increased from to

Bravenboer et al., 2005 [22]	Norland	Spine FN	2.4% 2.3%			g/cm²	Increased from to nM

Arwert et al., 2005 [23]	Hologic Inc.	Spine FN	NA 2.1%			g/cm²	Increased from to nM

Boguszewski et al., 2005 [24]	GE-Lunar	Spine FN	1.2% 1.5%			g/cm²	Increased from to μg/L

Benedini et al., 2006 [25]	Hologic Inc.	Spine	NA			g/cm²	Increased from to μg/L

Snyder et al., 2007 [26]	Hologic Inc.	Spine FN	0.37–0.51%			g/cm²	IGF1 SDS increased from to

Gotherstrom et al., 2007 [27]	GE-Lunar	Spine FN TB	0.5% 0.6% 0.4%			g/cm²	Increased from to μg/L

Rota et al., 2008 [28]	Hologic Inc.	Spine FN	1.0% 1.5%			z-score	Increased in men and in women

Fideleff et al., 2008 [10]	GE-Lunar	Spine FN TB	NA NA NA			z-score	IGF1 SDS increased from to

Conway et al., 2009 [29]	Hologic Inc.	Spine TB	NA NA			g/cm²	Increased from to μg/L

Van den Heijkant et al., 2011 [11]	Hologic Inc.	Spine FN TB	NA NA NA			g/cm²	NA

Elbornsson et al., 2012 [30]	GE-Lunar	Spine FN TB	<1.5%			g/cm²	Increased from to μg/L

Coefficient of variation; ^bnot available.