Effects of Growth Hormone Replacement Therapy on Bone Mineral Density in Growth Hormone Deficient Adults: A Meta-Analysis

Table 4

Subgroup analyses results of the association between GH treatment and BMD of FN.

Subgroups	Effects of GH treatment on BMD			Heterogeneity
	SMD	95% CI	P	𝐼^2 (%)	𝜒^2	P
Treatment time
≤2 yr	0.289	−0.009–0.587	0.057	51.2	14.36	0.045
>2 yr	0.440	0.119–0.761	0.007	76.9	34.70	0.000
GH usage
Fixed dosage	0.520	0.178–0.861	0.003	56.5	13.79	0.032
Dosage depending on serum IGF-1 values	0.289	0.007–0.571	0.045	72.3	32.51	0.000
Manufacturer of DXA scanner
Hologic Inc	0.306	0.018–0.595	0.037	49.7	15.89	0.044
GE-lunar	0.392	0.026–0.758	0.036	80.2	30.34	0.000
Geographic location^a
Europe	0.313	0.117–0.508	0.002	48.0	23.08	0.027
America	0.501	−0.227–1.229	0.177	86.1	21.54	0.000

aThere was no study including Oceanian subjects.