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International Journal of Endocrinology
Volume 2013 (2013), Article ID 282381, 7 pages
http://dx.doi.org/10.1155/2013/282381
Research Article

Association between Endocrine Disrupting Phenols in Colostrums and Maternal and Infant Health

1Research Center for Cell Fate Control, Sookmyung Women's University College of Pharmacy, Seoul 140-742, Republic of Korea
2Korea Testing & Research Institute, Gyeonggido 415-871, Republic of Korea
3Inje University Sanggye Paik Hospital, Seoul 139-707, Republic of Korea
4Mart Pediatric Clinic, Gyeonggido 456-824, Republic of Korea
5Division of Cancer Prevention and Controls, Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA

Received 31 December 2012; Accepted 28 March 2013

Academic Editor: Ewa Gregoraszczuk

Copyright © 2013 B. Yi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bisphenol A (BPA) and alkylphenols (APs) are well-known endocrine disrupting chemicals (EDCs) which may threat the next generations' health. We performed biomonitoring of these phenols in colostrums to assess risk of the phenols in breast-fed neonates. Study subjects were the lactating mothers who delivered babies within 2 weeks ( ; 30.67 3.45 years) and their neonates ( ; embryonic period, 39.1 1.5 weeks). BPA, nonylphenol (NP), and octylphenol (OP) in colostrums were quantified with LC/MS/MS. Information for environmental exposure sources of the phenols was obtained by questionnaires. As results, median level of BPA in colostrums was 7.8 ng/mL, while most NP or OP was not detected. Regarding health risks of phenols, levels of total NP in colostrums were elevated among sick mothers with toxemia, thyroid disorders, gastritis, and so forth than health mothers (3.51 4.98 versus 2.04 3.71 ng/mL, ). Dairy products intake and detergents use were positively correlated with total BPA levels ( ). In conclusion, we estimate most neonates who are exposed to BPA rather than NP or OP via colostrums and recommend continuous biomonitoring of the phenols to clarify their suspected health risk on neonates and pregnant or gestation mothers.