The Effects of Vitamin D on Gentamicin-Induced Acute Kidney Injury in Experimental Rat Model

Table 1

Clinical and laboratory findings.

	Control, 𝑛 = 10	Genta, 𝑛 = 10	Genta + Vit D,; 𝑛 = 10
SBP (mmHg)	120 ± 6	125 ± 10	112 ± 13^a
DBP (mmHg)	68 ± 4	75 ± 7	74 ± 8
Urine volume (cc)	3 ± 0.5	2.4 ± 0.4	3.4 ± 0.5^a
Urea (mg/dL)	91 ± 6	137 ± 6^a	149 ± 5^a
Creatinine (mg/dL)	0.74 ± 0.03	1.1 ± 0.1^a	1.6 ± 0.3^a
NGAL (ng/mL)	49.5 ± 7	390 ± 143^a	247 ± 112
GSH (nmol/mL)	0.4 ± 0.13	0.3 ± 0.04	0.6 ± 0.1^a
GGT (U/L)	1.3 ± 0.35	38 ± 37	59 ± 19^a
KIM-1 (ng/mL)	0.64 ± 0.05	4.7 ± 0.6^a	6 ± 0.5^a
TD	0.9 ± 0.1	2 ± 0^a	2.3 ± 0.2^a
TN	0	1.3 ± 0.2^a	1.2 ± 0.2^a
TIN	0.4 ± 0.2	1.4 ± 0.2^a	2 ± 0.1^ab
THS	0.75 ± 0.15	3.4 ± 0.4^a	6.3 ± 0.7^ab

SBP: systolic blood pressure; DBP: diastolic blood pressure; NGAL: neutrophil gelatinase-associated lipocalin; GSH: glutathione; KIM: kidney injury molecule; TD: tubular degeneration; TN: tubular necrosis; TIN: tubulointerstitial nephritis; THS: total histological score; 𝑃 < 0.05, ^aGroup versus Control, ^bGroup versus Genta.