Improved Glucose-Stimulated Insulin Secretion by Selective Intraislet Inhibition of Angiotensin II Type 1 Receptor Expression in Isolated Islets of db/db Mice
Figure 1
Expression in islet of AT1R in db/m mice and db/db mice. (a) Expression in islets of AT1R mRNA in db/m mice or db/db mice. Gene expression was measured by quantitative RT-PCR. Graphical presentation shows the relative AT1R mRNA abundance after normalization to actin. Data are presented as mean ± SD, * versus db/m group, . (b) Expression of AT1R protein in islets from db/m mice or db/db mice. Lysates from freshly isolated islets were analyzed for AT1R expression by western blot analysis. Results represent the mean ± SD. Blots from one representative experiments are shown. * versus db/m group, .
