International Journal of Endocrinology / 2013 / Article / Tab 3 / Clinical Study
A Randomised, Double-Blinded, Placebo-Controlled, Parallel Study of Vitamin D3 Supplementation with Different Schemes Based on Multiples of 25,000 IU Doses Table 3 25(OH)D serum concentration and number (%) of subjects who did not reach the target levels of 20 ng/mL and 30 ng/mL at all time points.
Visit 1 (week 2) Visit 2 (week 0) Visit 3 (week 2) Visit 4 (week 4) Visit 5 (week 8) Visit 6 (week 12) Group 1 25(OH)D Mean ± SD (min–max) 7.62 ± 2.11 (4.0–12.0) 9.08 ± 3.37 (4.0–19.0) 21.00 ± 5.97 (11.0–46.0) 26.93 ± 7.54 (14.0–45.0) 28.25 ± 8.31 (10.0–45.0) 28.63 ± 8.08 (13.0–49.0) n (%) with 25(OH)D ≤ 20 ng/mL40 (100) 38 (95) 21 (52) 9 (22) 6 (15) 6 (15) n (%) with 25(OH)D ≤ 30 ng/mL40 (100) 40 (100) 37 (92) 27 (67) 26 (65) 25 (62) Group 2 25(OH)D Mean ± SD (min–max) 13.72 ± 2.63 (8.0–20.0) 15.30 ± 3.38 (7.0–23.0) 25.55 ± 5.89 (12.0–41.0) 31.65 ± 7.60 (18.0–50.0) 28.15 ± 7.69 (14.0–46.0) 30.10 ± 8.15 (13.0–50.0) n (%) with 25(OH)D ≤ 20 ng/mL40 (100) 35 (87) 8 (20) 1 (2) 7 (17) 3 (7) n (%) with 25(OH)D ≤ 30 ng/mL40 (100) 40 (100) 35 (87) 20 (50) 27 (67) 24 (60) Group 3 25(OH)D Mean ± SD (min–max) 24.88 ± 2.75 (21.0–30.0) 24.38 ± 5.31 (12.0–38.0) 32.88 ± 5.63 (20.0–51.0) 33.90 ± 8.24 (24.0–62.0) 35.25 ± 7.22 (23.0–54.0) 33.90 ± 8.21 (5.0–50.0) n (%) with 25(OH)D ≤ 20 ng/mL0 (0) 10 (25) 1 (2) 0 (0) 0 (0) 1 (2) n (%) with 25(OH)D ≤ 30 ng/mL40 (100) 36 (90) 14 (35) 14 (35) 12 (30) 10 (25) Group 4 25(OH)D Mean ± SD (min–max) 38.21 ± 6.11 (31.0–51.0) 32.70 ± 10.01 (11.0–53.0) 34.85 ± 8.25 (21.0–56.0) 35.65 ± 10.49 (17.0–55.0) 36.25 ± 11.90 (20.0–67.0) 35.15 ± 13.37 (11.0–68.0) n (%) with 25(OH)D ≤ 20 ng/mL0 (0) 3 (15) 0 (0) 2 (10) 1 (5) 1 (5) n (%) with 25(OH)D ≤ 30 ng/mL0 (0) 6 (30) 7 (35) 2 (10) 8 (40) 9 (45) Placebo group (group 5 + 6 + 7 + 8) 25(OH)D Mean ± SD (min–max) 18.83 ± 10.89 (6.0–50.0) 19.09 ± 9.43 (5.0–42.0) 18.57 ± 8.48 (6.0–43.0) 19.06 ± 9.34 (6.0–39.0) 19.17 ± 9.41 (4.0–38.0) 20.74 ± 9.48 (4.0–39.0) n (%) with 25(OH)D ≤ 20 ng/mL20 (57) 19 (54) 21 (60) 21 (60) 21 (60) 19 (54) n (%) with 25(OH)D ≤ 30 ng/mL30 (86) 31 (89) 33 (94) 29 (83) 30 (86) 30 (86)