Review Article

Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity

Figure 1

Leptin stimulates nitric oxide (NO) release in perivascular adipose tissue (PVAT). Mice lacking leptin (ob/ob) do not exhibit NO production in perivascular adipocytes. NO release is restored in PVAT after 2-week subcutaneous leptin infusion. Data from [17].
402053.fig.001