Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity

Table 3

Increase in PVAT amount and adipocyte size in different models of obesity.

Species	Model	PVAT	Adipocyte size	Study reference
Wistar rat	HFD (6 mo)	Aortic	Increase	[19]
Wistar Kyoto rat	HFD (3 mo—60% cal from fat)	Aortic	Increase	[63]
Zucker fa/fa rat		Aortic	Increase	[63]
C57Bl6 mice	HFD (2 w—42% cal from fat)	Aortic	Increase	[56]
C57Bl6 mice	HFD (13–20 w—45% cal from fat)	Thoracic aortic	No change	[58]
C57Bl6 mice	HFD (8 w—45% cal from fat)	Mesenteric	Increase	[17]
C57Bl6 mice	HFD (32 w—45% cal from fat)	Mesenteric	Increase	[28]

HFD: high fat diet; mo: month; w: weeks.