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International Journal of Endocrinology
Volume 2013 (2013), Article ID 532850, 11 pages
http://dx.doi.org/10.1155/2013/532850
Research Article

Calcium Activity of Upper Thoracic Dorsal Root Ganglion Neurons in Zucker Diabetic Fatty Rats

1Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
2Non-Clinical Development, Novo Nordisk A/S, 2760 Maaloev, Denmark

Received 14 December 2012; Revised 19 February 2013; Accepted 20 February 2013

Academic Editor: Gunnar Gislason

Copyright © 2013 Marie Louise Ghorbani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. International Diabetes Federation. Diabetes Atlas, 2011, http://www.idf.org/.
  2. J. S. Alpert, S. R. Chipkin, and N. Aronin, “Diabetes mellitus and silent myocardial ischemia,” Advances in Cardiology, vol. 37, pp. 297–303, 1990. View at Scopus
  3. A. I. Vinik, T. Erbas, M. A. Pfeifer, E. L. Feldman, M. J. Stevens, and J. W. Russell, “Diabetic autonomic neuropathy,” in Ellenberg & Rifkin's Diabetes Mellitus, D. Porte, R. S. Sherwin, and A. Baron, Eds., chapter 46, pp. 789–804, McGraw-Hill, 6th edition, 2003.
  4. C. R. Kahn, G. C. Weir, G. L. King, A. M. Jacobson, A. C. Moses, and R. J. Smith, Eds., Joslin’s Diabetes Mellitus, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 14th edition, 2005.
  5. A. I. Vinik and D. Ziegler, “Diabetic cardiovascular autonomic neuropathy,” Circulation, vol. 115, no. 3, pp. 387–397, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. M. T. Johnstone and G. P. Kinzfogl, “Diabetes and heart disease,” in Diabetes and Cardiovascular Disease, M. T. Johnstone and A. Veves, Eds., Contemporary Cardiology, Series edited by C. P.Cannon, chapter 28, pp. 579–628, Humana Press, 2nd edition, 2005.
  7. A. I. Vinik, R. E. Maser, B. D. Mitchell, and R. Freeman, “Diabetic autonomic neuropathy,” Diabetes Care, vol. 26, no. 5, pp. 1553–1579, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. P. K. Thomas and D. R. Tomlinson, “Diabetic and hypoglycemic neuropathy,” in Peripheral Neuropathy, P. J. Dyck, P. K. Thomas, J. W. Griffin, P. A. Low, and J. F. Poduslo, Eds., chapter 64, pp. 1219–1250, Saunders, 1993.
  9. H. L. Pan, J. C. Longhurst, J. C. Eisenach, and S. R. Chen, “Role of protons in activation of cardiac sympathetic C-fibre afferents during ischaemia in cats,” Journal of Physiology, vol. 518, no. 3, pp. 857–866, 1999. View at Publisher · View at Google Scholar · View at Scopus
  10. S. T. Meller and G. F. Gebhart, “A critical review of the afferent pathways and the potential chemical mediators involved in cardiac pain,” Neuroscience, vol. 48, no. 3, pp. 501–524, 1992. View at Publisher · View at Google Scholar · View at Scopus
  11. R. D. Foreman, “Mechanisms of cardiac pain,” Annual Review of Physiology, vol. 61, pp. 143–167, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. D. C. Kuo, J. J. Oravitz, and W. C. DeGroat, “Tracing of afferent and efferent pathways in the left inferior cardiac nerve of the cat using retrograde and transganglionic transport of horseradish peroxidase,” Brain Research, vol. 321, no. 1, pp. 111–118, 1984. View at Publisher · View at Google Scholar · View at Scopus
  13. C. J. Benson, S. P. Eckert, and E. W. McCleskey, “Acid-evoked currents in cardiac sensory neurons: a possible mediator of myocardial ischemic sensation,” Circulation Research, vol. 84, no. 8, pp. 921–928, 1999. View at Scopus
  14. F. Cervero and J. M. A. Laird, “Visceral pain,” The Lancet, vol. 353, no. 9170, pp. 2145–2148, 1999. View at Publisher · View at Google Scholar · View at Scopus
  15. F. Cervero, “Sensory innervation of the viscera: peripheral basis of visceral pain,” Physiological Reviews, vol. 74, no. 1, pp. 95–138, 1994. View at Scopus
  16. G. Biessels and W. H. Gispen, “The calcium hypothesis of brain aging and neurodegenerative disorders: significance in diabetic neuropathy,” Life Sciences, vol. 59, no. 5-6, pp. 379–387, 1996. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Verkhratsky and P. Fernyhough, “Mitochondrial malfunction and Ca2+ dyshomeostasis drive neuronal pathology in diabetes,” Cell Calcium, vol. 44, no. 1, pp. 112–122, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. T. J. Huang, N. M. Sayers, P. Fernyhough, and A. Verkhratsky, “Diabetes-induced alterations in calcium homeostasis in sensory neurones of streptozotocin-diabetic rats are restricted to lumbar ganglia and are prevented by neurotrophin-3,” Diabetologia, vol. 45, no. 4, pp. 560–570, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. N. V. Voitenko, E. P. Kostyuk, I. A. Kruglikov, and P. G. Kostyuk, “Changes in calcium signalling in dorsal horn neurons in rats with streptozotocin-induced diabetes,” Neuroscience, vol. 94, no. 3, pp. 887–890, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. H. D. Schultz, “Cardiac vagal chemosensory afferents: function in pathophysiological states,” Annals of the New York Academy of Sciences, vol. 940, pp. 59–73, 2001. View at Scopus
  21. M. L. Ghorbani, C. Qin, M. Wu et al., “Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats,” Autonomic Neuroscience, vol. 165, no. 2, pp. 168–177, 2011.
  22. D. Chen and M. W. Wang, “Development and application of rodent models for type 2 diabetes,” Diabetes, Obesity and Metabolism, vol. 7, no. 4, pp. 307–317, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. G. J. Etgen and B. A. Oldham, “Profiling of Zucker diabetic fatty rats in their progression to the overt diabetic state,” Metabolism, vol. 49, no. 5, pp. 684–688, 2000. View at Scopus
  24. R. M. Paredes, J. C. Etzler, L. T. Watts, W. Zheng, and J. D. Lechleiter, “Chemical calcium indicators,” Methods, vol. 46, no. 3, pp. 143–151, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. D. C. Immke and E. W. McCleskey, “Protons open acid-sensing ion channels by catalyzing relief of Ca2+ blockade,” Neuron, vol. 37, no. 1, pp. 75–84, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Kress, S. Fetzer, P. W. Reeh, and L. Vyklicky, “Low pH facilitates capsaicin responses in isolated sensory neurons of the rat,” Neuroscience Letters, vol. 211, no. 1, pp. 5–8, 1996. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Kress, P. W. Reeh, and L. Vyklicky, “An interaction of inflammatory mediators and protons in small diameter dorsal root ganglion neurons of the rat,” Neuroscience Letters, vol. 224, no. 1, pp. 37–40, 1997. View at Publisher · View at Google Scholar · View at Scopus
  28. S. G. Lu, X. Zhang, and M. S. Gold, “Intracellular calcium regulation among subpopulations of rat dorsal root ganglion neurons,” Journal of Physiology, vol. 577, no. 1, pp. 169–190, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. E. Kostyuk, N. Pronchuk, and A. Shmigol, “Calcium signal prolongation in sensory neurones of mice with experimental diabetes,” NeuroReport, vol. 6, no. 7, pp. 1010–1012, 1995. View at Scopus
  30. E. Kostyuk, N. Voitenko, I. Kruglikov et al., “Diabetes-induced changes in calcium homeostasis and the effects of calcium channel blockers in rat and mice nociceptive neurons,” Diabetologia, vol. 44, no. 10, pp. 1302–1309, 2001. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Shmigol and E. P. Kostyuk, “Mechanisms responsible for calcium signal formation in murine primary sensory neurons: their impairment by experimentally evoked diabetes,” Neurophysiology, vol. 27, no. 5, pp. 261–269, 1995.
  32. K. E. Hall, A. A. F. Sima, and J. W. Wiley, “Opiate-mediated inhibition of calcium signaling is decreased in dorsal root ganglion neurons from the diabetic BB/W rat,” The Journal of Clinical Investigation, vol. 97, no. 5, pp. 1165–1172, 1996. View at Scopus
  33. N. V. Voitenko, I. A. Kruglikov, E. P. Kostyuk, and P. G. Kostyuk, “Effect of streptozotocin-induced diabetes on the activity of calcium channels in rat dorsal horn neurons,” Neuroscience, vol. 95, no. 2, pp. 519–524, 1999. View at Publisher · View at Google Scholar · View at Scopus
  34. L. Shutov, I. Kruglikov, O. Gryshchenko et al., “The effect of nimodipine on calcium homeostasis and pain sensitivity in diabetic rats,” Cellular and Molecular Neurobiology, vol. 26, no. 7-8, pp. 1541–1557, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. E. Kostyuk, N. Svichar, V. Shishkin, and P. Kostyuk, “Role of mitochondrial dysfunction in calcium signalling alterations in dorsal root ganglion neurons of mice with experimentally-induced diabetes,” Neuroscience, vol. 90, no. 2, pp. 535–541, 1999. View at Publisher · View at Google Scholar · View at Scopus
  36. M. J. Berridge, M. D. Bootman, and H. L. Roderick, “Calcium signalling: dynamics, homeostasis and remodelling,” Nature Reviews Molecular Cell Biology, vol. 4, no. 7, pp. 517–529, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. E. Carafoli, L. Santella, D. Branca, and M. Brini, “Generation, control, and processing of cellular calcium signals,” Critical Reviews in Biochemistry and Molecular Biology, vol. 36, no. 2, pp. 107–260, 2001. View at Scopus
  38. K. E. Hall, J. Liu, A. A. F. Sima, and J. W. Wiley, “Impaired inhibitory G-protein function contributes to increased calcium currents in rats with diabetic neuropathy,” Journal of Neurophysiology, vol. 86, no. 2, pp. 760–770, 2001. View at Scopus
  39. Z. Wei, L. Wang, J. Han et al., “Decreased expression of transient receptor potential vanilloid 1 impairs the postischemic recovery of diabetic mouse hearts,” Circulation Journal, vol. 73, no. 6, pp. 1127–1132, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. T. Strecker, A. Dieterle, P. W. Reeh, M. Weyand, and K. Messlinger, “Stimulated release of calcitonin gene-related peptide from the human right atrium in patients with and without diabetes mellitus,” Peptides, vol. 27, no. 12, pp. 3255–3260, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. J. X. Song, L. H. Wang, L. Yao, C. Xu, Z. H. Wei, and L. R. Zheng, “Impaired transient receptor potential vanilloid 1 in streptozotocin-induced diabetic hearts,” International Journal of Cardiology, vol. 134, no. 2, pp. 290–292, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. S. Hong and J. W. Wiley, “Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1,” The Journal of Biological Chemistry, vol. 280, no. 1, pp. 618–627, 2005. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Mandadi, P. Armati, and B. D. Roufogalis, “Real-time translocation adn function of PKCbII isoform in response to nociceptive signaling via the TRPV1 pain receptor,” Pharmaceuticals, vol. 4, pp. 1503–1517, 2011.
  44. Y.-H. Jin, M. Takemura, A. Furuyama, and N. Yonehara, “Peripheral glutamate receptors are required for hyperalgesia induced by capsaicin,” Pain Research and Treatment, vol. 2012, Article ID 915706, 8 pages, 2012. View at Publisher · View at Google Scholar