Table 2: Quantitative response to 10 s stimulation with 20 mM K+. The results were subcategorized according to whether they responded to the capsaicin protocol the respective neuron was stimulated with. Results are shown as median (5%–95% percentile).

AnimalCapsaicin response AUC0–180 s %-

ControlY15734.68 (3.05–138.27)1.05 (0.27–1.65)175.36 (39.50–290.96)
N39228.02 (3.02–93.19) 0.88 (0.25–1.30) 149.64 (42.24–233.10)
DiabeticY19342.97 (5.08–155.09)1.25 (0.38–1.96) 202.78 (60.60–353.75)
N38540.99 (3.45–105.17) *$1.01 (0.28–1.59) 170.37 (21.97–288.22)

AUC: Area under the curve for 0–180 s, : the absolute change in [Ca2+] (fluorescence ratio), %- : the change in [Ca2+] (fluorescence ratio) measured in % change from baseline. Y: Yes and N: No. < 0.001 versus corresponding control neurons, #P < 0.001 and $P < 0.05 versus corresponding capsaicin-responsive neurons.