Table 3: Results from stimulation with capsaicin-containing solutions. Results are shown as Median (5th percentile; 95th percentile).

AnimalStimulus

Control0.3/0.5 μM Cap320.22 (0.12; 0.88)31.13 (19.85; 148.10)2.94 (0.98; 15.09)0.10 (0.03; 0.61)0.23 (0.09; 0.68)0.23 (0.09; 0.71)
0.3/0.5 μM Cap + AC450.21 (0.11; 1.34)35.29 (20.89; 250.89)2.88 (0.72; 48.31)0.23 (0.01; 0.83)0.42 (0.08; 0.99)0.44 (0.08; 1.11)
0.3 μM Cap + AC + pH 6.0600.42 (0.12; 1.64)73.81 (22.70; 289.41)4.10 (0.85; 64.82)0.09 (0.01; 4.56)0.44 (0.12; 1.66)0.42 (0.11; 1.74)
0.5 μM Cap + AC + pH 6.0131.7 (0.21; 2.37)240.67 (30.89; 352.63)72.13 (1.58; 117.24)0.83 (0.12; 4.75)1.35 (0.25; 2.39)1.47 (0.25; 2.30)

Diabetic0.3/0.5 μM Cap550.41 (0.12; 1.50) * 61.54 (21.88; 218.25) #4.83 (1.13; 55.17) * 0.26 (0.03; 0.89) * 0.42 (0.07; 1.12)0.46 (0.07; 1.14) *
0.3/0.5 μM Cap + AC580.27 (0.11; 1.53)47.62 (20.81; 294.64)3.22 (0.90; 60.81)0.12 (0.03; 1.32)0.28 (0.13; 1.16)0.29 (0.13; 1.20
0.3 μM Cap + AC + pH 6.070.23 (0.11; 1.55)35.09 (24.44; 249.06)2.34 (1.33; 38.01)0.14 (0.03; 0.56)0.21 (0.08; 1.04)0.23 (0.08; 1.06)
0.5 μM Cap + AC + pH 6.0631.63 (0.16; 1.87)276.27 (22.75; 414.13)63.51 (2.87; 97.95)0.84 (0.02; 5.13)1.24 (0.11; 1.93)1.21 (0.11; 2.12)

Results are shown as , relative AUC (AUCcap/ ), peak height ( ), % increase from baseline ( ), relative peak height relative to peak height of the preceding K+ response ( cap/ K+ and %- /%- ). ; number of cells, AUC; area under the curve; cap, capsaicin. P < 0.05, P < 0.01 compared to control neurons.