Severely Obese Adolescents and Adults Exhibit a Different Association of Circulating Levels of Adipokines and Leukocyte Expression of the Related Receptors with Insulin Resistance

Table 1

Demographic, clinical, metabolic, haematological, and hormonal characteristics of the study population.

	Adolescents		Adults
	Lean	Obese	Lean	Obese
No.	19	17	15	15
Age (yrs)	14.3±0.1^b,c	15.0±0.5	32.1±2.7	36.5±1.9
Weight (kg)	60.2±1.9^a,c	116.4±8.2	74.9±2.4^a	139.9±5.0
Height (m)	1.7±0.0	1.7±0.0^b	1.8±0.0	1.8±0.0
BMI (kg/m^2)	20.5±0.5^a,c	40.3±2.2^b	24.1±0.8^a	45.4±1.3
Waist circumference (cm)	79.2±1.2^a,c	119.9±5.1^b,c	85.5±2.7^a	134.8±2.4
Hip circumference (cm)	94.1±1.2^a,c	124.4±4.6^b	97.4±1.6^a	132.0±4.2
Total cholesterol (mg/dL)	152.7±6.2^b,c	150.2±4.8^b,c	187.1±12.1	194.1±12.0
Triglycerides (mg/dL)	70.8±4.5^c	93.0±6.9^c	81.1±13.5^a	152.8±19.8
Glucose (mg/dL)	86.4±1.4	82.2±1.6	96.7±2.3	97.6±8.2
Insulin (μIU/mL)	7.2±1.3	11.9±1.7^b	4.1±0.7^a	12.0±1.4
HOMA-IR	1.6±0.3^c	2.4±0.3^b	1.0±0.2^a	3.1±0.6
CRP (mg/dL)	0.0±0.0^a,c	1.0±0.3^b	0.1±0.0^a	0.6±0.1
IGF-1 (ng/mL)	457.2±24.1^a,b,c	357.9±28.8^b,c	192.6±21.6	119.9±14.2
Neutrophils (%)	44.8±1.9	51.8±2.6	52.6±2.4	52.5±1.8
Lymphocytes (%)	41.2±1.6	35.2±2.2	34.9±2.3	36.1±1.8
Monocytes (%)	8.1±0.5	8.8±0.4	8.2±0.5	7.7±0.2
Eosinophils (%)	5.3±0.9	3.7±0.5	3.8±0.6	3.3±0.5
Basophils (%)	0.6±0.0	0.5±0.1	0.6±0.1	0.5±0.1
Neutrophils (10^9/L)	2.8±0.2^a,c	4.6±0.5^b	3.2±0.3^a	4.4±0.4
Lymphocytes (10^9/L)	2.5±0.1^a	3.0±0.3	2.2±0.2^a	2.9±0.1
Monocytes (10^9/L)	0.5±0.0	0.7±0.1	0.5±0.0	0.6±0.0
Eosinophils (10^9/L)	0.3±0.1	0.3±0.0	0.4±0.2	0.3±0.0
Basophils (10^9/L)	0.0±0.0	0.0±0.0	0.0±0.0	0.0±0.0

^a𝑃<0.05 versus the corresponding (adolescent or adult) obese group.
^b𝑃<0.05 versus the lean adult group.
^c𝑃<0.05 versus the obese adult group.