A Network Investigation on Idiopathic Hypogonadotropic Hypogonadism in China

Table 3

Characteristics of the 74 IHH patients, G group patients and G + A group patients.

	Total^a	G group	G + A group^b	𝑃^∗
Number (𝑛)	74	37	22
Age (yr)	27.3±3.4	27.16±3.60	27.36±2.7	0.821
Age at disease onset (yr)	15.2±6.6	15.83±7.06	14.46±6.17	0.777
Decreased testosterone (%)	74 (100)	74 (100)	74 (100)	1.000
Decreased FSH (%)	71 (95.9)	37 (100)	22 (100)	1.000
Decreased LH (%)	69 (93.2)	37 (100)	22 (100)	1.000
Penis length (cm)
Baseline	3.98±1.73	3.65±2.07	3.97±1.31	0.135
After treatment	7.61±2.63	6.91±2.58	9.41±2.26	0.002
Mean difference	3.64±2.60	3.26±2.74	5.43±2.02	0.001
𝑃 value	<0.001	<0.001	<0.001
Testicular volume (mL)
Baseline	4.11±2.12	4.32±2.70	2.36±1.87	0.215
After treatment	14.31±6.6289	14.79±8.49	13.61±9.29	0.419
Mean difference	10.20±5.82	10.47±6.29	11.26±5.37	0.243
𝑃 value	<0.001	<0.001	<0.001
Genital development, Tanner stage (I/II/III/IV/V)
Baseline	38/36/0/0/0	17/20/0/0/0	16/6/0/0	0.060
After treatment	1/14/38/19/2	1/8/17/10/1	0/3/17/2	0.613
𝑃 value	<0.001	<0.001	<0.001
Pubic hair development, Tanner stage (I/II/III/IV/V)
Baseline	46/28/0/0/0	18/19/0/0/0	16/6/0/0/0	0.103
After treatment	3/12/19/28/12	3/6/13/12/3	0/0/3/10/9	0.004
𝑃 value	<0.001	<0.001	<0.001
Breast development, Tanner stage (I/II/III/IV/V)
Baseline	18/30/19/7/0	6/15/12/4/0	6/10/3/3/0	0.404
After treatment	0/33/29/12/0	0/15/13/9/0	0/9/10/3/0	0.589
𝑃 value	<0.001	0.001	<0.001
Beard (%)
Baseline	9 (12.2)	5 (13.5)	3 (13.6)	0.989
After treatment	53 (71.6)	23 (62.2)	18 (81.8)	0.195
Mean difference	44 (59.5)	18 (48.6)	15 (68.2)	0.144
𝑃 value	<0.001	<0.001	<0.001
Laryngeal prominence (%)
Baseline	12 (16.2)	6 (16.2)	1 (4.5)	0.180
After treatment	49 (66.2)	21 (56.8)	16 (72.7)	0.220
Mean difference	37 (50.0)	15 (40.5)	15 (68.2)	0.040
𝑃 value	<0.001	0.001	<0.001
Erection (%)
Baseline	27 (36.5)	11 (29.7)	9 (40.9)	0.553
After treatment	67 (90.5)	33 (89.2)	19 (86.4)	0.745
Mean difference	40 (54.1)	22 (59.5)	10 (45.5)	0.439
𝑃 value	<0.001	<0.001	<0.001
Spermatorrhea (%)
Baseline	8 (10.8)	4 (10.8)	4 (18.2)	0.684
After treatment	44 (59.5)	17 (45.9)	17 (77.3)	0.037
Mean difference	36 (48.6)	13 (35.1)	13 (59.1)	0.073
𝑃 value	<0.001	0.002	<0.001
Normalization of testosterone (%)
Baseline	0 (0)	0 (0)	0 (0)	1.000
After treatment	47 (66.2)	19 (51.7)	20 (90.9)	0.004
𝑃 value	<0.001	<0.001	<0.001

G group: patients receiving HCG or HCG + HMG treatment.
G + A group: patients receiving HCG + T or HCG + HMG + T treatment.
^aFor all 74 patients included in the study.
^bFor G + A group excluding 3 patients who were still receiving exogenous testosterone replacement.
*The difference between G group and G + A group.