Enhanced Healing of Diabetic Wounds by Subcutaneous Administration of Human Umbilical Cord Derived Stem Cells and Their Conditioned Media

Figure 1

Effects of CM, UC-MSC, and PBS on wound closure. (a) Representative photographs of the wounds of every alternate day from day 0 to day 14 after injury. Scale bar is 1 mm. (b) Comparison of wound closure rates expressed as a percentage of its initial wound area every alternate day after wounding (𝑛=6; ^∗𝑃<0.05, CM versus UC-MSC or PBS); (𝑛=6; ^∗∗𝑃<0.05, UC-MSC versus PBS); (𝑛=6; ^∗∗∗𝑃<0.05, CM versus PBS). (c) Wound measurement of all groups at day 8 and day 14 (𝑛=6; ^∗𝑃<0.05, CM versus UC-MSC or PBS); (𝑛=6; ^∗∗𝑃<0.05, UC-MSC versus PBS). (d) Relative granulation tissue area of wounds treated with CM, UC-MSC, and PBS at day 14 (𝑛=6; ^∗𝑃<0.05, CM versus UC-MSC or PBS); (𝑛=6; ^∗∗𝑃<0.05, UC-MSC versus PBS).

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