Cholesterol Contributes to Diabetic Nephropathy through SCAP-SREBP-2 Pathway
Figure 5
Oil Red O staining (200×, (a) and (b)). Increased Oil Red O staining was observed in the glomerular and tubular cells of diabetic rats, and treatment with atorvastatin 10 mg/kg/day reverses these changes. PAS staining (400×, (c) and (d)). Significant mesangial expansion was observed in the glomeruli of diabetic rats, and atorvastatin alleviated this change. (c) PASM staining (400×, (e) and (f)). PASM staining showed the basement membrane thickness in the glomeruli and tubules of diabetic rats, which were changed by atorvastatin treatment. NC, (a), (c), and (e); DM, (b), (d), and (f).
