The IVF Outcome Counseling Based on the Model Combining DHEAS and Age in Patients with Low AMH Prior to the First Cycle of GnRH Antagonist Protocol of Ovarian Stimulation
Table 3
Baseline patient characteristics, treatment variables, and IVF outcomes of the patients grouped according to the cut-off values for female age and DHEAS level predictive of clinical pregnancy (cutoffs are selected by ROC curve analysis).
Age category (years)
<37.5
≥37.5
>5.7
≤5.7
>5.7
≤5.7
DHEAS category (mol/L)
Group 1
Group 2
Group 3
Group 4
()
()
()
()
Patient characteristics
Age (y)
34.0 ± 2.7(3)(4)
34.1 ± 1.8(3)(4)
39.7 ± 1.7(1)(2)
40.5 ± 1.9(1)(2)
BMI (kg/m2)
23.5 ± 3.8
23.0 ± 3.3(3)(4)
26.2 ± 5.0(2)
24.5 ± 3.7(2)
AFC
7.0 ± 4.0
7.4 ± 3.6
6.0 ± 3.0
5.8 ± 3.7
AMH (pmol/L)
3.2 ± 1.9
3.5 ± 1.8(4)
2.3 ± 1.5
2.6 ± 1.6(2)
DHEAS (µmol/L)
7.0 ± 0.7(2)(4)
3.6 ± 1.2(1)(3)
6.9 ± 0.9(2)(4)
3.5 ± 1.4(1)(3)
FSH (IU/L)
9.0 ± 2.9
9.6 ± 8.3
9.1 ± 4.1
10.3 ± 6.9
LH (IU/L)
4.3 ± 1.8
4.6 ± 2.6
3.9 ± 1.1
5.0 ± 2.2
(pmol/L)
192 ± 73
217 ± 103
248 ± 130
239 ± 153
(nmol/L)
1.9 ± 0.6(2)(4)
1.2 ± 0.5(1)(3)
2.0 ± 1.9(2)(4)
1.3 ± 0.6(1)(3)
Treatment variables
Duration of stimulation (d)
10.7 ± 1.3
10.3 ± 1.6
10.6 ± 3.0
10.7 ± 1.5
Total gonadotrophins used (IU)
3200 ± 392
2953 ± 643
3167 ± 901
3064 ± 633
Number of ICSI cycles, % ()
73.9 (17/23)
72.2 (26/36)
71.4 (5/7)
76.2 (32/42)
IVF outcomes
Number of oocytes retrieved
3.1 ± 1.4(4)
3.2 ± 2.4(4)
2.9 ± 1.7
2.0 ± 1.5(1)(2)
Number of oocytes eligible for fertilization
2.5 ± 0.8(4)
2.2 ± 1.1(4)
2.1
1.6(1)(2)
Number of embryos transferred
1.5 ± 1.1
1.3 ± 1.2
0.9 ± 1.1
1.0 ± 0.9
Implantation rate per embryo transferred (%)
32.4(2)(4)
8.6(1)(4)
12.5
3.8(1)(2)
Clinical pregnancy rate per cycle initiated (%)
37.5(2)(4)
8.9(1)
11.1
2.0(1)
Note: values are presented as mean ± SD. AFC: antral follicle count; AMH: anti-Müllerian hormone; BMI: body mass index Conversion formulas for the AMH, DHEAS, , and values in mass units are as follows: ng/mL = pmol/L: 7.14, g/dL 0.027 = mol/L, pg/mL 3.67 = pmol/L, and ng/dL 0.0347 = mmol/L, respectively. Fisher's exact test, Chi-quadrat test, and Kruskal-Wallis test with post-hoc analysis according to Conover were used for between-group comparison where appropriate. Superscripted numbers in parentheses denote P < 0.05 compared with Group 1; P < 0.05 compared with Group 2; P < 0.05 compared with Group 3; P < 0.05 compared with Group 4.
