Comparative Analysis of Clinical, Hormonal and Morphological Studies in Patients with Neuroendocrine ACTH-Producing Tumours

Table 3

Distribution of pituitary and extrapituitary ACTH-secreting tumours based on the results of immunoexpression of tropic hormones.

Hormone expression	Corticotropinomas,; 𝑛=46	Ectopic ACTH-secreting tumours		𝑃, 𝜒^2
		IHC characteristics	Morphology
Monohormonal	ACTH, 𝑛=32 (69.6%)	Total, 𝑛=6 (33.3%): ACTH (𝑛=4); CRH (𝑛=2)	3 AC/1 TC; 1 AC/1 TC	0.2
Bihormonal	Total, 𝑛=15 (32.6%): ACTH-PRL, 𝑛=7; ACTH-FSH, 𝑛=1; ACTH-STH, 𝑛=4; ACTH-LH, 𝑛=3	Total, 𝑛=6 (33.3%): ACTH-CRH, 𝑛=5; ACTH-PRL, 𝑛=1	2 AC/2 TC/1 SCLC; 1 TC	0.1
Polyhormonal	Total, 𝑛=9 (19.6%): ACTH-STH-PRL, 𝑛=4; ACTH-STH-PRL-FSH, 𝑛=1; ACTH-STH-LH-FSH, 𝑛=1; ACTH-PRL-LH-FSH, 𝑛=1; ACTH-STH-PRL-LH-FSH, 𝑛=1; ACTH-PRG-LH, 𝑛=1	Total, 𝑛=6 (33.3%): ACTH-CRH-STH, 𝑛=2; ACTH-STH-PRL, 𝑛=1; CRH-STH-PRL, 𝑛=1; CRH-STH-PRL-LH, 𝑛=1; ACTH-CRH-STH-PRL, 𝑛=1	2 AC; 1 AC; 1 TC; 1 TC; 1 TC	0.2