Table 3: Distribution of pituitary and extrapituitary ACTH-secreting tumours based on the results of immunoexpression of tropic hormones.

Hormone expression Corticotropinomas,
Ectopic ACTH-secreting tumours
IHC characteristicsMorphology

MonohormonalACTH, (69.6%)Total, (33.3%):
ACTH ( )
CRH ( )
3 AC/1 TC
1 AC/1 TC
0.2

BihormonalTotal, (32.6%):
ACTH-PRL,
ACTH-FSH,
ACTH-STH,
ACTH-LH,
Total, (33.3%):
ACTH-CRH,
ACTH-PRL,
2 AC/2 TC/1 SCLC
1 TC
0.1

PolyhormonalTotal, (19.6%):
ACTH-STH-PRL,
ACTH-STH-PRL-FSH,
ACTH-STH-LH-FSH,
ACTH-PRL-LH-FSH,
ACTH-STH-PRL-LH-FSH,
ACTH-PRG-LH,
Total, (33.3%):
ACTH-CRH-STH,
ACTH-STH-PRL,
CRH-STH-PRL,
CRH-STH-PRL-LH,
ACTH-CRH-STH-PRL,
2 AC
1 AC
1 TC
1 TC
1 TC
0.2