Anti-Müllerian Hormone: A Valuable Addition to the Toolbox of the Pediatric Endocrinologist

Figure 8

Signaling pathway of the AMH protein. Model showing how processing of AMH may regulate the assembly of the receptor signaling complex. Cleavage of full-length AMH results in a conformational change in the C-terminal domain, indicated by the shape and color change, which allows binding of AMRH-II. Binding of AMHRII induces dissociation of the proregion via a negative allosteric interaction between the receptor- and proregion-binding sites on the C-terminal dimer, indicated by the shape change. Results presented in this paper are consistent with proregion dissociation occurring before type I receptor engagement, but this has not been proven. Type I and II receptor-binding sites on the C-terminal dimer are indicated by either a I or a II; black labels indicate sites on the front of the dimer, and white labels indicate sites on the back of the dimer. From [2], Copyright The Endocrine Society, 2010, with permission.