Dysfunction of Collagen Synthesis and Secretion in Chondrocytes Induced by Wisp3 Mutation

Figure 6

Change of intracellular collagen content and extracellular collagen secretion in mutant chondrocytes analyzed by ¹⁴C-proline incorporation assay. (a) Time course of ¹⁴C-proline labeled collagen (detected by radioactivity) secreted to the supernatant of the cultured chondrocytes. (b) Time course of ¹⁴C-proline labeled collagen content in cultured chondrocytes. (c) Ratio of secreted collagen to intracellular collagen.

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