About this Journal Submit a Manuscript Table of Contents
International Journal of Endocrinology
Volume 2013 (2013), Article ID 679763, 9 pages
http://dx.doi.org/10.1155/2013/679763
Research Article

Dysfunction of Collagen Synthesis and Secretion in Chondrocytes Induced by Wisp3 Mutation

1Institute of Endocrinology and Metabolism, The Second Xiang-Ya Hospital of Central South University, Changsha, Hunan 410011, China
2Department of Endocrinology and Metabolism, Xiang-Ya Hospital of Central South University, Changsha, Hunan 410008, China

Received 23 December 2012; Revised 21 January 2013; Accepted 28 January 2013

Academic Editor: Peng-Fei Shan

Copyright © 2013 Min Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. R. Hurvitz, W. M. Suwairi, W. Van Hul et al., “Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia,” Nature Genetics, vol. 23, no. 1, pp. 94–98, 1999. View at Publisher · View at Google Scholar · View at Scopus
  2. B. Perbal, C. Martinerie, R. Sainson, M. Werner, B. He, and B. Roizman, “The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 3, pp. 869–874, 1999. View at Scopus
  3. Y. Nishida, T. Matsubara, T. Tobina et al., “Effect of low-intensity aerobic exercise on insulin-like growth factor-I and insulin-like growth factor-binding proteins in healthy men,” International Journal of Endocrinology, vol. 2010, Article ID 452820, 8 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. B. Perbal, D. R. Brigstock, and L. F. Lau, “Report on the second international workshop on the CCN family of genes,” Journal of Clinical Pathology, vol. 56, no. 2, pp. 80–85, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. G. W. Zuo, C. D. Kohls, B. C. He et al., “The CCN proteins: important signaling mediators in stem cell differentiation and tumorigenesis,” Histology and Histopathology, vol. 25, no. 6, pp. 795–806, 2010. View at Scopus
  6. A. Leask, “CCN6 (WISP3): a new anti-cancer therapy?” Journal of Cell Communication and Signaling, vol. 4, no. 4, pp. 199–200, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. S. A. Al-Awadi, T. I. Farag, and K. Naguib, “Spondyloepiphyseal dysplasia tarda with progressive arthropathy,” Journal of Medical Genetics, vol. 21, no. 3, pp. 193–196, 1984. View at Scopus
  8. A. Dalal, G. Bhavani SL, P. P. Togarrati et al., “Analysis of the WISP3 gene in Indian families with progressive pseudorheumatoid dysplasia,” American Journal of Medical Genetics A, vol. 158, pp. 2820–2828, 2012.
  9. S. Ehl, M. Uhl, R. Berner, L. Bonafé, A. Superti-Furga, and A. Kirchhoff, “Clinical, radiographic, and genetic diagnosis of progressive pseudorheumatoid dysplasia in a patient with severe polyarthropathy,” Rheumatology International, vol. 24, no. 1, pp. 53–56, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Ye, H. W. Zhang, W. J. Qiu et al., “Patients with progressive pseudorheumatoid dysplasia: from clinical diagnosis to molecular studies,” Molecular Medicine Reports, vol. 5, pp. 190–195, 2012.
  11. M. F. Kahn, “Chondrodysplasic rheumatism,” British Journal of Rheumatology, vol. 37, no. 8, article 917, 1998. View at Scopus
  12. E. Y. Liao, Y. Q. Peng, H. D. Zhou et al., “Gene symbol: WISP3. Disease: spondyloepiphyseal dysplasia tarda with progressive arthropathy,” Human Genetics, vol. 115, no. 2, article 169, 2004. View at Scopus
  13. E. Y. Liao, Y. Q. Peng, H. D. Zhou et al., “Gene symbol: WISP3. Disease: spondyloepiphyseal dysplasia tarda with progressive arthropathy,” Human Genetics, vol. 115, no. 2, article 174, 2004.
  14. Y. Q. Peng, E. Y. Liao, H. M. Gu et al., “Pathology and molecular pathogenesis of spondyloepiphyseal dysplasia tarda with progressive arthropathy caused by compound CCN6 heterogeneous gene mutations,” Zhonghua Yi Xue Za Zhi, vol. 84, no. 21, pp. 1796–1803, 2004. View at Scopus
  15. H. D. Zhou, Y. H. Bu, Y. Q. Peng et al., “Cellular and molecular responses in progressive pseudorheumatoid dysplasia articular cartilage associated with compound heterozygous WISP3 gene mutation,” Journal of Molecular Medicine, vol. 85, no. 9, pp. 985–996, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Pal, W. Huang, X. Li, K. A. Toy, Z. Nikolovska-Coleska, and C. G. Kleer, “CCN6 modulates BMP signaling via the Smad-independent TAK1/p38 pathway, acting to suppress metastasis of breast cancer,” Cancer Research, vol. 72, pp. 4818–4828, 2012.
  17. W. Huang, M. E. Gonzalez, K. A. Toy, M. Banerjee, and C. G. Kleer, “Blockade of CCN6 (WISP3) activates growth factor-independent survival and resistance to anoikis in human mammary epithelial cells,” Cancer Research, vol. 70, no. 8, pp. 3340–3350, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. Q. H. Liang, Y. Jiang, X. Zhu et al., “Ghrelin attenuates the osteoblastic differentiation of vascular smooth muscle cells through the ERK pathway,” PLoS ONE, vol. 7, no. 4, Article ID e33126, 2012.
  19. C. G. Kleer, Y. Zhang, and S. D. Merajver, “CCN6 (WISP3) as a new regulator of the epithelial phenotype in breast cancer,” Cells Tissues Organs, vol. 185, no. 1–3, pp. 95–99, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Katsumi, E. A. Tuley, I. Bodo, and J. E. Sadler, “Localization of disulfide bonds in the cystine knot domain of human von Willebrand factor,” Journal of Biological Chemistry, vol. 275, no. 33, pp. 25585–25594, 2000. View at Publisher · View at Google Scholar · View at Scopus
  21. W. E. Kutz, Y. Gong, and M. L. Warman, “WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice,” Molecular and Cellular Biology, vol. 25, no. 1, pp. 414–421, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. M. B. Goldring, J. R. Birkhead, L. F. Suen et al., “Interleukin-1β-modulated gene expression in immortalized human chondrocytes,” Journal of Clinical Investigation, vol. 94, no. 6, pp. 2307–2316, 1994. View at Scopus
  23. B. Perbal, “NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues,” Journal of Clinical Pathology, vol. 54, no. 2, pp. 57–79, 2001. View at Publisher · View at Google Scholar · View at Scopus