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International Journal of Endocrinology
Volume 2013 (2013), Article ID 727164, 8 pages
http://dx.doi.org/10.1155/2013/727164
Research Article

Relationship between Serum Levels of OPG and TGF-β with Decreasing Rate of BMD in Native Chinese Women

Institute of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, 139 Renmin-Zhong Road, Changsha, Hunan 410011, China

Received 27 October 2012; Revised 30 December 2012; Accepted 2 January 2013

Academic Editor: Guang-Da Xiang

Copyright © 2013 Xi-Yu Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The objective of this study was to investigate the relationship between serum levels of OPG, TGF-β1, and TGF-β2 and BMD decrease rate (BDR) in native Chinese women. This cross-sectional study was performed on 465 healthy native Chinese women aged 35–80 years. Serum levels of OPG, TGF-β1, and TGF-β2 were determined. BDR was measured by DXA at the posteroanterior spine, hip, and distal forearm. At all skeletal sites tested, there was a negative correlation between BDR and serum levels of both OPG ( to –0.230, all P = 0.007–0.000) and TGF-β2 ( to –0.173, all P = 0.029–0.000) and a positive correlation between BDR and serum TGF-β1 ( , all ). After adjustment for age and BMI, there were no statistically significant correlations between serum levels of OPG or TGF-β2 and BDR. However, statistically significant correlations between serum TGF-β1 and BDR at the lumbar spine and ultradistal forearm remained. Multiple linear regression stepwise analysis showed that serum OPG could explain 1.4–3.7% of BDR variation. Serum TGF-β1 was a positive determinant of BDR and could explain 5.3–13.3% of BDR variation.