The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue

Figure 2

Model of the development of chronic inflammation in WAT. Adipocytes begin to grow as a result of factors such as excess energy intake and lack of exercise, and MCP-1 is secreted from these enlarged adipocytes. Macrophages infiltrate into WAT by the action of MCP-1, and as a result, increased expression of inflammatory adipokines (TNF-α, MCP-1, and IL-6) and decreased expression of anti-inflammatory adipokines (adiponectin) occur in WAT. Dysregulated expression of adipokines-induced inflammation of WAT contributes to the development of insulin resistance.